Abstract: Provided herein are methods of identifying genomic region(s) predictive of an outcome of treatment with a cell therapy and/or of a phenotype of function of the cells. In some embodiments, the methods include epigenetic and/or epigenomic analyses of the cells in connection with methods for preparing engineered cells for cell therapy and/or predicting response to a cell therapy, e.g., engineered cells for cell therapy. In some embodiments, the methods include steps to assess, characterize and analyze changes or modifications in an epigenetic property of gene region or regions, such as chromatin accessibility, nucleosome occupancy, histone modification, spatial chromosomal conformation, transcription factor occupancy and/or DNA methylation. In some embodiments, the epigenetic and/or epigenomic analysis includes determining the epigenetic properties of a cell, e.g., an engineered cell for cell therapy.

Abstract: A secure private network connectivity system (SNCS) within a cloud service provider infrastructure (CSPI) is described that provides secure private network connectivity between external resources residing in a customer's on-premise environment and the customer's resources residing in the cloud. The SNCS provides secure private bi-directional network connectivity between external resources residing in a customer's external site representation and resources and services residing in the customer's VCN in the cloud without a user (e.g., an administrator) of the enterprise having to explicitly configure the external resources, advertise routes or set up site-to-site network connectivity.

Abstract: A secure private network connectivity system (SNCS) within a cloud service provider infrastructure (CSPI) is described that provides secure private network connectivity between external resources residing in a customer's on-premise environment and the customer's resources residing in the cloud. The SNCS provides secure private bi-directional network connectivity between external resources residing in a customer's external site representation and resources and services residing in the customer's VCN in the cloud without a user (e.g., an administrator) of the enterprise having to explicitly configure the external resources, advertise routes or set up site-to-site network connectivity.

Abstract: Systems and techniques are described for robust radar-based gesture-recognition. A radar system detects radar-based gestures on behalf of application subscribers. A state machine transitions between multiple states based on inertial sensor data. A no-gating state enables the radar system to output radar-based gestures to application subscribers. The state machine also includes a soft-gating state that prevents the radar system from outputting the radar-based gestures to the application subscribers. A hard-gating state prevents the radar system from detecting radar-based gestures altogether. The techniques and systems enable the radar system to determine when not to perform gesture-recognition, enabling user equipment to automatically reconfigure the radar system to meet user demand. By so doing, the techniques conserve power, improve accuracy, or reduce latency relative to many common techniques and systems for radar-based gesture-recognition.

Abstract: Some headphone systems include two ear cups, a headband assembly, an interface system and a control system. Each ear cup may include an ear cup enclosure, an ear pad assembly, a speaker system and a hinge assembly. The hinge assembly may be disposed within the ear cup enclosure such that it is not visible from outside the ear cup. The headband assembly may connect with each of the ear cups via the hinge assembly. The interface system may include at least one interface and a plurality of input source buttons disposed on at least one of the ear cups. Each of the input source buttons may be configured for selecting a source of audio data received via the at least one interface. The control system may be configured for controlling the speaker system to reproduce audio data received via the interface and selected by one of the input source buttons.

Abstract: A waste disposal system for receiving pharmaceutical waste material including at least one of a solid phase pharmaceutical waste material and a liquid phase pharmaceutical waste material is provided. The waste receiver includes a receiver body defining an opening. The waster receiver further includes an inner surface defining a container volume in fluid communication with the opening, and an outer surface opposite the inner surface. The outer surface defines a lock passageway separate from the opening. The system further includes a bracket adapted to be secured to a fixed surface and a locking assembly coupled to the bracket and adapted to releasably secure the waste receiver to the fixed surface. The locking assembly includes a lock housing sized to be removably positioned at least partially within the lock passageway.

Abstract: A grounded neutral fault detector that includes induction circuits and a controller is provided. The controller is configured to determine a frequency of a test signal by measuring load noise based on a first leakage signal corresponding to a first current imbalance between the line conductor and the neutral conductor for the load without the test signal being injected, analyzing a frequency spectrum of the load noise, and selecting the frequency of the test signal. The controller is further configured to inject the test signal at the selected frequency to the neutral conductor, measure impedance of a current loop formed by a potential grounded neutral fault based on a second leakage signal corresponding to a second current imbalance with the test signal being injected, and determine a grounded neutral fault.

Abstract: A grounded neutral fault detector that includes induction circuits and a controller is provided. The controller is configured to determine a frequency of a test signal by measuring load noise based on a first leakage signal corresponding to a first current imbalance between the line conductor and the neutral conductor for the load without the test signal being injected, analyzing a frequency spectrum of the load noise, and selecting the frequency of the test signal. The controller is further configured to inject the test signal at the selected frequency to the neutral conductor, measure impedance of a current loop formed by a potential grounded neutral fault based on a second leakage signal corresponding to a second current imbalance with the test signal being injected, and determine a grounded neutral fault.

Abstract: A multi-language component management system allows users to create and reuse reusable components in various supported languages for a desired state configuration system. The system manages creation and construction of reusable multi-language components. The system may receive a request to create an instance of a component in a first configuration language. The request may include input parameters for creating the instance. The component may be authored in a second configuration language different from the first configuration language and may include resources such as child components that depend on the component. The system may generate output properties containing information for generating the plurality of resources. The system may recursively construct the child components that depend on the component, which may in turn result in construction of additional resources. In response to the dependency of the component is resolved, the system outputs a set of completely resolved output properties.

Abstract: Provided herein are methods for producing engineered T cells that express a recombinant receptor, such as for use in cell therapy. In some aspects, the provided methods include one or more steps for incubating the cells under stimulating conditions, introducing a recombinant polypeptide to the cells through transduction or transfection, and/or cultivating the cells under conditions that promote proliferation and/or expansion, in which one or more steps is carried out in the presence of an agent that inhibits mammalian target of rapamycin (mTOR) activity. In some aspects, cultivation is performed in the presence of an agent that inhibits mammalian target of rapamycin (mTOR) activity. In some aspects, the provided methods produce genetically engineered T cells with improved persistence and/or anti-tumor activity in vivo.

Abstract: Provided are cells, e.g., engineered immune cells, expressing recombinant or engineered molecules involved in metabolic pathways, such as those that promote or inhibit one or more metabolic steps, reactions, or pathways, for example, in T cells. Such molecules include those that induce or repress a particular functional outcome or metabolic event, for example, one that promotes differentiation or reprogramming into a particular phenotypic state, such as memory, long-lived, activated or activatable, non-exhausted, phenotype or stem-like phenotype. The cells generally further express an immune receptor, such as an antigen receptor, which may be an engineered receptor, such as a CAR or recombinant TCR, or may be a natural immune receptor. Also provided are cells, such as T cells, expressing such molecules and combinations thereof, compositions comprising such cells, nucleic acids such as vectors encoding the same, and methods of administration to subjects in adoptive cell therapy.

Abstract: A retained object tag, and a method of detecting the presence of a retained object or the retained object tag in a medical image. The method can include different steps such as identifying one or more potential sites in the medical image where the retained object or retained object tag may be present. The method can also include analyzing one or more features of the identified potential site against one or more predetermined properties of the retained object or the retained object tag. And the method can include determining whether the identified potential site is a retained object or a retained object tag based in part or more upon the analyzed feature.

Abstract: Provided are chimeric receptors for engineering cells for adoptive therapy, including T cells, and the genetically engineered cells. In some embodiments, the chimeric receptors, such as chimeric antigen receptors (CARs) are modified in a junction region by one or more amino acid modifications such that peptide fragments of such region exhibit a lower binding affinity for a human leukocyte antigen (HLA) and/or the region exhibits reduced immunogenicity, including following administration to a subject. In some aspects, also provided are methods and compositions for engineering and producing cells expressing such chimeric receptors, compositions containing the cells, and method for their administration to subjects. In some embodiments, features of the chimeric receptors and engineered cells containing the chimeric receptors result in methods that provide for increased or improved activity, efficacy and/or persistence.

Abstract: An angle impact tool includes a handle assembly extending along a first axis, a prime mover in the handle, an output shaft rotatable about the first axis, and a work attachment connected to the handle assembly. An output drive is supported in the work attachment for rotation about an output axis perpendicular to the first axis. A gear assembly including a spur gear is positioned within the work attachment to transfer torque from the prime mover about the first axis to the output drive about the output axis. An impact mechanism is positioned within the work attachment and includes a hammer and an anvil. The hammer rotates under the influence of the prime mover and is operable to periodically deliver an impact load to the anvil. The output drive rotates about the output axis under the influence of the impact load being transmitted to the output drive by the anvil.

Abstract: Provided are cells, e.g., engineered immune cells, expressing recombinant or engineered molecules involved in metabolic pathways, such as those that promote or inhibit one or more metabolic steps, reactions, or pathways, for example, in T cells. Such molecules include those that induce or repress a particular functional outcome or metabolic event, for example, one that promotes differentiation or reprogramming into a particular phenotypic state, such as memory, long-lived, activated or activatable, non-exhausted, phenotype or stem-like phenotype. The cells generally further express an immune receptor, such as an antigen receptor, which may be an engineered receptor, such as a CAR or recombinant TCR, or may be a natural immune receptor. Also provided are cells, such as T cells, expressing such molecules and combinations thereof, compositions comprising such cells, nucleic acids such as vectors encoding the same, and methods of administration to subjects in adoptive cell therapy.

Abstract: Provided are chimeric receptors for engineering cells for adoptive therapy, including T cells, and the genetically engineered cells. In some aspects, also provided are methods and compositions for engineering and producing the cells, compositions containing the cells, and method for their administration to subjects. In some embodiments, the cells, such as T cells, contain genetically engineered antigen receptors that specifically bind to antigens, such as a chimeric antigen receptor (CAR), and which contain an intracellular signaling domain capable of inducing TRAF6-mediated signaling. In some embodiments, features of the cells and methods provide for increased or improved activity, efficacy and/or persistence.

Abstract: Architecture that includes an asynchronous library which remembers the synchronization context that initiated an asynchronous method call and when the request is completed, the library restores the synchronization context of the calling thread before executing a callback. This ensures that the callback executes on the same thread as the original asynchronous request. The callback to the asynchronous operation that asynchronous library provides automatically “jumps threads” to maintain thread affinity.

Abstract: A reusable fluid dispensing system comprising a fluid dispensing head with a descending dip tube having an end and a container for holding fluid that is detachably connected to the fluid dispensing head. The container has a bottom that has a single lower recess region to receive the dip tube end, a detachable base member defining at least one region and, within that region, at least one accessory. The accessory is from a group consisting of a funnel for use in dispensing fluid concentrate and dilution fluid in to the container, a reusable non-paper sheet-like or pad-like element for smoothly spreading dispensed fluid onto a surface or scouring or polishing the surface, and concentrate for making the fluid when dissolved in dilution fluid. In addition, methods of use are taught.

Abstract: Methods, systems, and devices are provided for navigating a robot along a route. Navigation is accomplished using an image sensor mounted on the robot, which captures an image of a target. The target comprises a plurality of data zones and a plurality of data indicators organized with no more than one data indicator located within one data zone. The target has a target code based on which of the data zones contains the plurality of data indicators. A target distance between the robot and the target is determined, and, if the target distance is below a distance threshold, then an instruction, based on the target code is used to command the robot.