Abstract: Aspects of the present disclosure generally relate to sanitizing wipe that provides a visual indication that a sufficient amount of abrasive scrubbing has occurred for a given period of time to properly sterilize various medical devices and medical equipment including needless intravenous hub-and-port systems. The sanitizing wipe can change color when used to properly sanitize medical equipment. The sanitizing swab can comprise a plurality of layers of non-woven material (e.g., cotton) in addition to an indicating film disposed between two layers of non-woven material. The indicating film can comprise a polymeric film and a plurality of microencapsulated dyes incorporated into the polymeric film. The microencapsulated dyes can be adapted to burst upon sufficient force being applied thereto, and the bursting of the microencapsulated dyes can cause the sanitizing wipe to undergo a change in visual state (e.g., change color).