Patents by Inventor Lucas R. Blauch

Lucas R. Blauch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microfluidic guillotine for splitting cellular structures
    Publication number: 20230175933
    Abstract: Splitting of biological samples is provided by flowing the samples through a flow splitter where the sample strikes a stationary blade and is split into two pieces that end up in separate output channels. Samples can be single cells or multi-cellular samples. The split ratio of the pieces can be 50:50 or it can be other values as determined by design. To first order, the split ratio of the pieces is the same as the split ratio of the fluid flows in the output channels.
    Type: Application
    Filed: January 30, 2023
    Publication date: June 8, 2023
    Inventors: Lucas R. Blauch, Sindy K. Y. Tang
  • RNA Replication Using Transcription Polymerases
    Publication number: 20220259645
    Abstract: Compositions and methods for amplifying RNA by replication using transcription polymerases are disclosed. Such replicated RNAs can be used in various applications such as RNAi therapeutics, diagnostic probes, RNA sequencing, directed evolution of RNA aptamers without intermediate conversion to DNA, and RNA vaccines. The transcription polymerases comprise T7 bacteriophage RNA polymerase.
    Type: Application
    Filed: July 7, 2020
    Publication date: August 18, 2022
    Inventors: Nimit Jain, Andrew Z. Fire, Lucas R. Blauch, Sindy K. Y. Tang, Karen L. Artiles, Julia T. Garcia-Daou, Y. Whitney Yin, Michal R. Szymanski
  • Microfluidic guillotine for splitting cellular structures
    Publication number: 20190368979
    Abstract: Splitting of biological samples is provided by flowing the samples through a flow splitter where the sample strikes a stationary blade and is split into two pieces that end up in separate output channels. Samples can be single cells or multi-cellular samples. The split ratio of the pieces can be 50:50 or it can be other values as determined by design. To first order, the split ratio of the pieces is the same as the split ratio of the fluid flows in the output channels.
    Type: Application
    Filed: May 29, 2019
    Publication date: December 5, 2019
    Inventors: Lucas R. Blauch, Sindy K. Y. Tang