Abstract: A medical instrument system comprises an imaging probe including a distal tip terminating at a first distal end of the imaging probe and a lens disposed at the first distal end. The imaging probe including a first sealing feature on an external surface of the imaging probe. The medical instrument also comprises an elongated medical instrument including a distal portion terminating at a second distal end and including a working channel configured to slidably receive the imaging probe. The working channel including a second sealing feature on a surface of the working channel. The first sealing feature and the second sealing feature are shaped and configured to contact one another to prevent the passage of fluid between the first and second sealing features.

Abstract: Sizing catheters that include an inner member and an outer member. The inner member includes an elongate shaft and a plurality of radiopaque markers spaced axially from each other and secured to an outer surface of the shaft, the span of radiopaque markers defining a first portion of the inner member. The outer member that is disposed snugly around and in substantial contact with the inner member along at least the first portion of the inner member.

Abstract: A medical tool comprises an elongated tubular section having a body wall including a plurality of slits and a rigid needle tip coupled to a distal end of the tubular section. The tool further includes a flexible jacket coupled with the elongated tubular section by extending into the plurality of slits to block a fluid passageway through the plurality of slits.

Abstract: A medical instrument system comprises an imaging probe including a distal tip terminating at a first distal end of the imaging probe and a lens disposed at the first distal end. The imaging probe including a first sealing feature on an external surface of the imaging probe. The medical instrument also comprises an elongated medical instrument including a distal portion terminating at a second distal end and including a working channel configured to slidably receive the imaging probe. The working channel including a second sealing feature on a surface of the working channel. The first sealing feature and the second sealing feature are shaped and configured to contact one another to prevent the passage of fluid between the first and second sealing features.

Abstract: Sizing catheters that include an inner member and an outer member. The inner member includes an elongate shaft and a plurality of radiopaque markers spaced axially from each other and secured to an outer surface of the shaft, the span of radiopaque markers defining a first portion of the inner member. The outer member that is disposed snugly around and in substantial contact with the inner member along at least the first portion of the inner member.

Abstract: Sizing catheters that include an inner member and an outer member. The inner member includes an elongate shaft and a plurality of radiopaque markers spaced axially from each other and secured to an outer surface of the shaft, the span of radiopaque markers defining a first portion of the inner member. The outer member that is disposed snugly around and in substantial contact with the inner member along at least the first portion of the inner member.

Abstract: A medical instrument system comprises an imaging probe including a distal tip terminating at a first distal end of the imaging probe and a lens disposed at the first distal end. The imaging probe including a first sealing feature on an external surface of the imaging probe. The medical instrument also comprises an elongated medical instrument including a distal portion terminating at a second distal end and including a working channel configured to slidably receive the imaging probe. The working channel including a second sealing feature on a surface of the working channel. The first sealing feature and the second sealing feature are shaped and configured to contact one another to prevent the passage of fluid between the first and second sealing features.

Abstract: What is described is a minimally invasive system comprising an elongate sheath and an elongate instrument slidably disposed within a lumen of the sheath. The sheath includes a flexible tube portion including a plurality of slots, a sheath element, and a rigid tube section, wherein the flexible tube portion is fixedly coupled to a distal end of the sheath element, and the rigid tube section is fixedly coupled to a distal end of the flexible tube. The lumen extends through the sheath element, the flexible tube portion, and the rigid tube section and defines a longitudinal axis of the sheath. The instrument includes a rigid distal portion adapted to slide between a retracted configuration in which the rigid distal portion is retracted within the rigid tube section and an extended configuration in which the rigid distal portion at least partially extends from the rigid tube section.

Abstract: Systems and methods for cutting, or trimming, a catheter at a specified location along the length of the catheter. The catheter preferably includes a stop feature which interacts with an elongate member of the cutting system to determine the catheter is in a proper position to be cut.

Abstract: The invention is a method of delivering and deploying a tissue shaping device in a lumen within a patient, with the tissue shaping device including an anchor. In some embodiments the method includes the steps of: inserting a delivery catheter into the lumen; percutaneously delivering the device to a target site within the lumen through a delivery catheter; operating an actuator to expose an anchor; and operating the actuator to lock the anchor. In other, the method includes the steps of: inserting a delivery catheter into the lumen; moving the device from a cartridge into the delivery catheter; delivering the device to a target site within the lumen; operating an actuator to move the delivery catheter with respect to the anchor to expose the anchor; and expanding the anchor.

Abstract: Systems and methods for cutting, or trimming, a catheter at a specified location along the length of the catheter. The catheter preferably includes a stop feature which interacts with an elongate member of the cutting system to determine the catheter is in a proper position to be cut.

Abstract: A system for selectively deploying a medical device includes a cartridge that is engageable with a proximal end of a delivery catheter that is routed to a desired location in a patient's body. An advancement mechanism is provided for advancing the medical device out of the cartridge and into the delivery catheter for deploying the medical device at the desired location in the patient's body.

Abstract: Systems and methods for cutting, or trimming, a catheter at a specified location along the length of the catheter. The catheter preferably includes a stop feature comprising a difference in a physical characteristic between a first portion of the catheter and a second portion of the catheter which interacts with an elongate member of the cutting system to determine the catheter is in a proper position to be cut.

Abstract: The invention is a tissue shaping system, including a tissue shaping device with an expandable anchor and a lock; a delivery catheter; a delivery mechanism adapted to deliver the tissue shaping device from outside a patient to a target site within a lumen within the patient via the delivery catheter; and an actuator adapted to deliver an actuation force to the lock to lock the anchor in an expanded configuration. The invention is also a system adapted to percutaneously deliver and deploy a tissue shaping device at a target site within a lumen of a patient. The system includes: a handle; a delivery mechanism supported by the handle and adapted to deliver the tissue shaping device from outside the patient to the treatment site via a delivery catheter; and an actuator supported by the handle and adapted to deliver an actuation force to lock an anchor of the tissue shaping device in an expanded configuration.

Abstract: The invention is a tissue shaping system, including a tissue shaping device with an expandable anchor and a lock; a delivery catheter; a delivery mechanism adapted to deliver the tissue shaping device from outside a patient to a target site within a lumen within the patient via the delivery catheter; and an actuator adapted to deliver an actuation force to the lock to lock the anchor in an expanded configuration. The invention is also a system adapted to percutaneously deliver and deploy a tissue shaping device at a target site within a lumen of a patient. The system includes: a handle; a delivery mechanism supported by the handle and adapted to deliver the tissue shaping device from outside the patient to the treatment site via a delivery catheter; and an actuator supported by the handle and adapted to deliver an actuation force to lock an anchor of the tissue shaping device in an expanded configuration.

Abstract: Systems and methods for cutting, or trimming, a catheter at a specified location along the length of the catheter. The catheter preferably includes a stop feature which interacts with an elongate member of the cutting system to determine the catheter is in a proper position to be cut.

Abstract: A system for selectively deploying a medical device includes a cartridge that is engageable with a proximal end of a delivery catheter that is routed to a desired location in a patient's body. An advancement mechanism is provided for advancing the medical device out of the cartridge and into the delivery catheter for deploying the medical device at the desired location in the patient's body.

Abstract: An assembly delivers an intra-bronchial device into an air passageway. The assembly includes a delivery catheter having a deployment lumen with a distal end arranged to receive the intra-bronchial device in a delivery configuration, and arranged to be passed down a trachea and advanced to a location for deployment of the intra-bronchial device, and to deploy the intra-bronchial device by retracting the deployment catheter. The assembly further includes a bronchial device supply tool associated with the distal end, and arranged to carry the intra-bronchial device in a storage configuration and to load the intra-bronchial device in a delivery configuration into the deployment lumen of distal end, and the intra-bronchial device carried in the supply tool in a storage configuration. An embodiment of the supply tool includes a storage portion, a delivery portion, and a configuration-changing portion coupled between the storage portion and the delivery portion.

Abstract: A system for selectively deploying a medical device includes a cartridge that is engageable with a proximal end of a delivery catheter that is routed to a desired location in a patient's body. An advancement mechanism is provided for advancing the medical device out of the cartridge and into the delivery catheter for deploying the medical device at the desired location in the patient's body.

Abstract: Methods of sealing an injection site of a tissue are provided, where therapeutic agent has been injected into tissue, resulting in increased efficiency or agent uptake. Also provided are methods for delivering therapeutic agent to a tissue, which include injecting a therapeutic agent into a tissue and subsequently sealing the injection site, or engaging an injection device with the tissue for a sufficient period of time that sealing is not necessary to avoid leakage of the therapeutic agent. In one embodiment radio frequency cautery is used to seal the injection site upon needle removal from the tissue. In other embodiments, the injection site is sealed by resistance heating, laser heating or plugging the site with a solid plug or coagulating material at the site.