Patents by Inventor Lucia CHÁVEZ GUTIÉRREZ

Lucia CHÁVEZ GUTIÉRREZ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ?-secretase stabilizing compound screening assay
    Patent number: 11346848
    Abstract: The present invention relates to the field of neurodegenerative diseases. More specifically, the present invention relates to a screening assay to produce compounds stabilizing the gamma-secretase enzyme substrate complex, thereby increasing gamma-secretase processivity while attenuating the release of longer A? peptides. More specifically, gamma-secretase stabilizing compounds increase thermostability of the enzyme/substrate complexes acting in the sequential ?-secretase processing of APP, to result in reduced amyloidogenic A? production, thereby preventing Alzheimer disease.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: May 31, 2022
    Assignees: VIB VZW, Katholieke Universiteit Leuven, KU Leuven R&D
    Inventors: Bart De Strooper, Lucia Chávez Gutiérrez, Maria Szaruga
  • GAMMA-SECRETASE STABILIZING COMPOUND SCREENING ASSAY
    Publication number: 20190339292
    Abstract: The present invention relates to the field of neurodegenerative diseases. More specifically, the present invention relates to a screening assay to produce compounds stabilizing the gamma-secretase enzyme substrate complex, thereby increasing gamma-secretase processivity while attenuating the release of longer A? peptides. More specifically, gamma-secretase stabilizing compounds increase thermostability of the enzyme/substrate complexes acting in the sequential ?-secretase processing of APP, to result in reduced amyloidogenic A? production, thereby preventing Alzheimer disease.
    Type: Application
    Filed: January 10, 2018
    Publication date: November 7, 2019
    Inventors: Bart DE STROOPER, Lucia CHÁVEZ GUTIÉRREZ, Maria SZARUGA