Abstract: A valvular system for the extraction and/or addition of liquids held in flexible sterilizable containers of plastic material, including an elastomeric semirigid hydraulic seal having two major superior and inferior faces and at least one minor lateral face. A housing of plastic material for the said elastomeric element. The valvular system is characterized in that at least one of the said major faces of the elastomeric element is at least partially spaced from the housing body.

Abstract: A method and apparatus for producing and filling sterilized bags includes the steps of: feeding a film material from which the bags are formed from at least one reel; printing information on the film; cleaning the film in two stages which includes ultrasonic vibration and washing with water; drying the film; sterilizing it with ultraviolet rays; applying valves to the film; welding, punching and printing the film to generate a large bag; filling the large bag with liquid and inert gas; applying a second welding orthogonal to the first welding direction to divide the larger bag into a plurality of final bag having a predetermined size; cutting the film into the individual bags and testing the integrity of each bag; and vacuum packaging the bags and/or megablistering it.

Abstract: A method of preparation of valves for a flat, flexible, sterilizable container capable of sterilely containing a liquid to be removed under absolutely sterile conditions which comprises the steps of:forming a two-layer laminate including a first layer of a copolymer of ethylene with a minor proportion of butylene and a second layer of an amide polymer; forming a pocket in the two-layer laminate wherein the first layer forms the inner surface of the pocket; providing an elastomeric core element having spaced major faces; inserting the core element into the pocket in the two-layer laminate; providing a three-layer laminate including a first outer layer of a major portion of a propylene polymer, a second outer layer of a copolymer of ethylene with a minor proportion of butylene, and an intermediate layer of an amide polymer; orienting the three-layer laminate so that the second outer layer thereof is apposed to the first layer of the two-layer laminate; expelling air surrounding the core element in the pocket; w

Abstract: A flat, flexible, sterilizable container for a liquid to be maintained and extracted under sterile conditions, said container comprising: a body having walls formed by a three-layer laminate including an outermost layer of a propylene polymer, an innermost layer of a copolymer of ethylene with a small amount of butylene, and an intermediate layer of an amide polymer; and a valve carried by said body comprising an elastomeric core whose spaced major faces are covered, one, by a three-layer laminate similar to said body wall forming laminate and, the other, by a two-layer laminate including a first layer of a copolymer of ethylene with little butylene and a second layer of an amide polymer.

Abstract: A process for making a filter element for use in intravenous infusions, comprises positioning a filter fabric between two half molds and then injecting plastic material into the two half molds to provide a tubular filter element transected by the filter fabric. In order to promote bonding between the fabric and the plastic, and thereby to avoid the formation of a transverse plane of weakness in the filter element coincident with the plane of the fabric, the half molds are provided with spaced cutting means in the form of knives arranged in a peripheral series about the mold in such position as to penetrate the fabric at a plurality of spaced points when the mold is closed with the fabric between the mold halves.