Patents by Inventor Luciano Mueller

Luciano Mueller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12218497
    Abstract: A disclosed switching apparatus, such as a circuit breaker, includes a transistor switch circuit connected between a power input terminal and a load terminal, and, connected to the power input terminal and bypassing the transistor switch circuit, a switchable bypass leg that is optically switched by a series-connected photoconductive semiconductor switch (PCSS). The transistor switch circuit includes at least one cascade of three or more series-connected transistors, and at least one resistor network configured to divide a voltage from a voltage source across a cascade of series-connected transistors. Operating the switch apparatus includes detecting whether a sensed electric current is in a fault condition, opening the transistor switch circuit upon detecting a fault condition, and then closing the PCSS so that the electric current is diverted onto a switchable bypass path. The opening of the transistor switch circuit comprises turning OFF a normally-ON transistor switch circuit.
    Type: Grant
    Filed: October 12, 2022
    Date of Patent: February 4, 2025
    Assignees: National Technology & Engineering Solutions of Sandia, LLC, UNM Rainforest Innovations
    Inventors: Gregory Pickrell, Jason Christopher Neely, Lee Gill, Jacob Mueller, Luciano Andres Garcia Rodriguez, Jack David Flicker, Emily Ann Schrock, Robert Kaplar, Harold P. Hjalmarson, Jane Lehr
  • Patent number: 11623013
    Abstract: Deuterated polymer-biomolecule conjugates and the synthesis and use of deuterated polymer-biomolecule conjugates for detecting the location of specific molecules, e.g., cell surface molecules, in a subject, and for imaging various processes within the body, for detecting the location of molecules associated with disease pathology, and for monitoring disease progression are disclosed.
    Type: Grant
    Filed: November 10, 2020
    Date of Patent: April 11, 2023
    Inventors: Michael J. Smith, Haiying Tang, Paul E. Morin, Harold J. Malone, Luciano Mueller
  • Publication number: 20210060184
    Abstract: Deuterated polymer-biomolecule conjugates and the synthesis and use of deuterated polymer-biomolecule conjugates for detecting the location of specific molecules, e.g., cell surface molecules, in a subject, and for imaging various processes within the body, for detecting the location of molecules associated with disease pathology, and for monitoring disease progression are disclosed.
    Type: Application
    Filed: November 10, 2020
    Publication date: March 4, 2021
    Inventors: Michael J. SMITH, Haiying Tang, Paul E Morin, Harold J. Malone, Luciano MUELLER
  • Patent number: 8504304
    Abstract: A method of enhancing the throughput and applicability of NMR-based structure determination of protein-ligand complexes is disclosed. The method circumvents the need for protein sequence-specific resonance assignments and combines NMR data analysis and ligand docking methods into an integrated process. In one embodiment, NMR data is used to filter docking results to identify the most consistent binding modes, thereby providing structural information in a high-throughput fashion without the need for assigning protein resonances. Trial assignments for protein-ligand nuclear Overhauser effect (NOE) interactions are also produced by the method.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: August 6, 2013
    Assignee: Bristol-Myers Squibb Company
    Inventors: Keith Lewis Constantine, Brian Lee Claus, Malcolm Evan Davis, William Joseph Metzler, Luciano Mueller
  • Patent number: 8420830
    Abstract: The present invention relates generally to novel macrocycles of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables A, B, C, D, L, M, W, Z1, Z2, Z3, Z4, R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: April 16, 2013
    Assignee: Bristol-Myers Squibb Company
    Inventors: Nicholas Ronald Wurtz, Eldon Scott Priestley, Daniel L. Cheney, Peter W. Glunz, Xiaojun Zhang, Brandon Parkhurst, Vladimir Ladziata, Luciano Mueller
  • Publication number: 20120143580
    Abstract: A method of enhancing the throughput and applicability of NMR-based structure determination of protein-ligand complexes is disclosed. The method circumvents the need for protein sequence-specific resonance assignments and combines NMR data analysis and ligand docking methods into an integrated process. In one embodiment, NMR data is used to filter docking results to identify the most consistent binding modes, thereby providing structural information in a high-throughput fashion without the need for assigning protein resonances. Trial assignments for protein-ligand nuclear Overhauser effect (NOE) interactions are also produced by the method.
    Type: Application
    Filed: February 3, 2012
    Publication date: June 7, 2012
    Inventors: Keith Lewis Constantine, Brian Lee Claus, Malcolm Evan Davis, William Joseph Metzler, Luciano Mueller
  • Patent number: 8150634
    Abstract: A method of enhancing the throughput and applicability of NMR-based structure determination of protein-ligand complexes is disclosed. The method circumvents the need for protein sequence-specific resonance assignments and combines NMR data analysis and ligand docking methods into an integrated process. In one embodiment, NMR data is used to filter docking results to identify the most consistent binding modes, thereby providing structural information in a high-throughput fashion without the need for assigning protein resonances. Trial assignments for protein-ligand nuclear Overhauser effect (NOE) interactions are also produced by the method.
    Type: Grant
    Filed: November 10, 2005
    Date of Patent: April 3, 2012
    Assignee: Bristol-Myers Squibb Company
    Inventors: Keith Lewis Constantine, Brian Lee Claus, Malcolm Evan Davis, William Joseph Metzler, Luciano Mueller
  • Publication number: 20100113488
    Abstract: The present invention relates generally to novel macrocycles of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables A, B, C, D, L, M, W, Z1, Z2, Z3, Z4, R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.
    Type: Application
    Filed: December 19, 2007
    Publication date: May 6, 2010
    Inventors: Nicholas Ronald Wurtz, Eldon Scott Priestley, Daniel L. Cheney, Peter W. Glunz, Xiaojun Zhang, Brandon Parkhurst, Vladimir Ladziata, Luciano Mueller
  • Publication number: 20030092027
    Abstract: The invention provides methods of using two-dimensional nuclear magnetic resonance to identify compounds that bind to a target compound.
    Type: Application
    Filed: May 31, 2002
    Publication date: May 15, 2003
    Inventors: Luciano Mueller, Li-An Xu, Chin-Hua Frank Shen