Abstract: In a heteronuclear system, the indirect detection of nuclei S, of weak gyromagnetic ratio, coupled to nuclei I, of strong gyromagnetic ratio, is accomplished by generation of zero and double quantum coherence between the I and S spin systems, during a preparatory period, t.sub.p. The zero and double quantum transitions are then interchanged at the midpoint of the evolution period, t.sub.1, producing an echo modulated only by S and I-I interactions at the end of the period t.sub.1, at which time the zero and double quantum coherence is then converted to I spin single quantum coherence yielding a free induction decay wave form S(t.sub.2) for given t.sub.1. The period, t.sub.1, is then varied to obtain a two-dimensional function S(t.sub.1, t.sub.2) which is then fully transformed to the frequency domain obtaining S(.omega..sub.1, .omega..sub.2) whereby the chemical shift of the coupled S spin is obtained along the .omega..sub.1 axis and the chemical shift of the I spin is obtained along the .omega..sub.2 axis.