Patents by Inventor Lucie Parenicová
Lucie Parenicová has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230212634Abstract: The present invention relates to the animal-free production of animal-derived proteins for human consumption by expression of such proteins, e.g. ovalbumin, in fungal cells. The invention relates to fungal cells modified for the production of animal-derived proteins, such as ovalbumin and to methods wherein these cells are used for the production of animal-derived proteins.Type: ApplicationFiled: January 14, 2021Publication date: July 6, 2023Applicant: The Protein Brewery B.V.Inventors: Joyce Josephine Elisabeth Arnouts, María Vázquez Vitali, Lucie Parenicová, Niels Lauret, Maloe Kleine Haar, Jos Reijngoud, Stefan Robert Marsden, Wilhelmus Theodorus Antonius Maria De Laat
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Patent number: 9307776Abstract: The present invention relates to novel lipase polynucleotide sequences, their corresponding proteins as well as ways of manufacturing said sequences and said proteins and use of the proteins in the preparation of food compositions. The invention further relates to methods for releasing proteins from the exterior of a host cell as well as to a method for killing micro-organisms.Type: GrantFiled: January 30, 2014Date of Patent: April 12, 2016Assignee: DSM IP ASSETS B.V.Inventors: Lucie Parenicova, Ronald Busink, Jan Metske Van Der Laan
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Patent number: 9181573Abstract: The present invention relates to a method for improving protein yield. The method comprises modifying the value of a set of relevant protein features to fall within an optimal range or to become more close to an optimal value for one or more protein features in the eukaryotic host.Type: GrantFiled: March 8, 2010Date of Patent: November 10, 2015Assignee: DSM IP ASSETS B.V.Inventors: Jan Metske Van Der Laan, Liang Wu, Johannes Andries Roubos, Lucie Parenicova, Alrik Pieter Los, Noel Nicolaas Maria Elisabeth Van Peij, Jan Herman Pel
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Publication number: 20140377407Abstract: This invention relates to a novel alpha-amylase, a process for its preparation and the use of the amylase. The invention relates to a newly identified polynucleotide sequence from Alicyclobacillus pohliae comprising a gene that encodes the novel alpha-amylase enzyme. The invention features the full length coding sequence of the novel gene as well as the amino acid sequence of the full-length functional protein of the gene. The invention also relates to methods of using these proteins in industrial processes, for example in food industry, such as the baking industry. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins and cells.Type: ApplicationFiled: January 29, 2013Publication date: December 25, 2014Applicant: DSM IP ASSETS B.V.Inventor: Lucie Parenicova
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Publication number: 20140186494Abstract: The present invention relates to novel lipase polynucleotide sequences, their corresponding proteins as well as ways of manufacturing said sequences and said proteins and use of the proteins in the preparation of food compositions. The invention further relates to methods for releasing proteins from the exterior of a host cell as well as to a method for killing micro-organisms.Type: ApplicationFiled: January 30, 2014Publication date: July 3, 2014Applicant: DSM IP ASSETS B.V.Inventors: Lucie PARENICOVA, Ronald BUSINK, JAN Metske VAN DER LAAN
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Patent number: 8703463Abstract: The present invention relates to novel lipase polynucleotide sequences, their corresponding proteins as well as ways of manufacturing said sequences and said proteins and use of the proteins in the preparation of food compositions. The invention further relates to methods for releasing proteins from the exterior of a host cell as well as to a method for killing micro-organisms.Type: GrantFiled: March 8, 2010Date of Patent: April 22, 2014Assignee: DSM IP Assets B.V.Inventors: Lucie Parenicova, Ronald Busink, Jan Metske Van Der Lann
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Patent number: 8642290Abstract: The present invention relates to functional cDNA and genomic sequences encoding PrtT proteins, which are transcriptional activity on a protease promoter, to PrtT proteins and their uses. The invention further relates to two distinct types of filamentous fungal cells. Filamentous fungal cells are transformed to over-express these PrtT proteins: this type of filamentous fungus will be highly suited as protease producer. Alternatively, the endogenous prtT genes of filamentous fungal cells are inactivated: this type of filamentious fungus is highly suited for the production of any polypeptide native or not which is highly sensitive for protease degradation. The PrtT proteins of the invention provide means for identification of functional homologues in other species.Type: GrantFiled: July 2, 2010Date of Patent: February 4, 2014Assignee: DSM IP Assets B.V.Inventors: Noël Nicolaas Maria Elisabeth van Peij, Lucie Parenicova
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Patent number: 8426182Abstract: This invention relates to an alpha-amylase, a process for its preparation and the use of the amylase. The invention relates to a newly identified polynucleotide sequence from Alicyclobacillus pohliae comprising a gene that encodes the alpha-amylase enzyme. The invention features the full-length coding sequence of the gene as well as the amino acid sequence of the full-length functional protein of the gene. The invention also relates to methods of using these proteins in industrial processes, for example in food industry, such as the baking industry. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins and cells.Type: GrantFiled: July 23, 2012Date of Patent: April 23, 2013Assignee: DSM IP Assets B.V.Inventor: Lucie Parenicova
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Publication number: 20110318752Abstract: The present invention relates to a method for improving protein yield. The method comprises modifying the value of a set of relevant protein features to fall within an optimal range or to become more close to an optimal value for one or more protein features in the eukaryotic host.Type: ApplicationFiled: March 8, 2010Publication date: December 29, 2011Applicant: DSM IP ASSETS B.V.Inventors: Jan Metske Van Der Laan, Liang Wu, Johannes Andries Roubos, Lucie Parenicova, Alrik Pieter Los, Noel Nicolaas Maria Elisabeth Van Peij, Jan Herman Pel
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Publication number: 20110311679Abstract: The present invention relates to novel lipase polynucleotide sequences, their corresponding proteins as well as ways of manufacturing said sequences and said proteins and use of the proteins in the preparation of food compositions. The invention further relates to methods for releasing proteins from the exterior of a host cell as well as to a method for killing micro-organisms.Type: ApplicationFiled: March 8, 2010Publication date: December 22, 2011Applicant: DSM IP ASSETS B.V.Inventors: Lucie Parenicova, Ronald Busink, Jan Metske Van Der Lann
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Publication number: 20110165656Abstract: The present invention relates to functional cDNA and genomic sequences encoding PrtT proteins, which have transcriptional activity on a protease promoter, to PrtT proteins and to their use. The invention further relates to two distinct types of filamentous fungal cells. Filamentous fungal cells are transformed to over-express these PrtT proteins: this type of filamentous fungus will be highly suited as protease producer. Alternatively, the endogenous prtT genes of filamentous fungal cells are inactivated: this type of filamentous fungus is highly suited for the production of any polypeptide native or not which is highly sensitive for protease degradation. The PrtT proteins of the invention provide means for identification of functional homologues in other species.Type: ApplicationFiled: July 2, 2010Publication date: July 7, 2011Applicant: DSM IP Assets B.V.Inventors: Noël Nicolaas Maria Elisabeth van Peij, Lucie Parenicova
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Patent number: 7794974Abstract: The present invention relates to functional cDNA and genomic sequences encoding PrtT proteins, which have transcriptional activity on a protease promoter, to PrtT proteins and to their use. The invention further relates to two distinct types of filamentous fungal cells. Filamentous fungal cells are transformed to over-express these PrtT proteins: this type of filamentous fungus will be highly suited as protease producer. Alternatively, the endogenous prtT genes of filamentous fungal cells are inactivated: this type of filamentous fungus is highly suited for the production of any polypeptide native or not which is highly sensitive for protease degradation. The PrtT proteins of the invention provide means for identification of functional homologues in other species.Type: GrantFiled: October 11, 2005Date of Patent: September 14, 2010Assignee: DSM IP Assets B.V.Inventors: Noël Nicolaas Maria Elisabeth van Peij, Lucie Parenicova
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Publication number: 20090176219Abstract: We have discovered DNA binding sites which are specifically recognized by PrtT, a transcriptional activator for protease genes. The DNA binding site can be defined structurally by a consensus nucleotide sequence and functionally by PrtT's ability to regulate transcriptional activation through that sequence. Both PrtT and its cognate DNA binding site (i.e., the nucleotide sequence in each promoter that is recognized by PrtT) can be used in a gene expression system. Possession of only a PrtT transcriptional activator is insufficient, its cognate DNA binding site is necessary for recognition by PrtT (i.e., binding to the site and activating transcription under appropriate conditions). A functional site, such as one obtained from a wild-type fungal gene, will confer PrtT-dependent transcriptional activation on 3?-downstream sequences. A mutation of a wild-type promoter that results in a non-functional site will abolish PrtT-dependent transcriptional activation of 3?-downstream sequences.Type: ApplicationFiled: October 24, 2006Publication date: July 9, 2009Inventors: Lucie Parenicova, Noël Nicolaas Maria Elisabeth Van Peij
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Publication number: 20080108105Abstract: The present invention relates to functional cDNA and genomic sequences encoding PrtT proteins, which have transcriptional activity on a protease promoter, to PrtT proteins and to their use. The invention further relates to two distinct types of filamentous fungal cells. Filamentous fungal cells are transformed to over-express these PrtT proteins: this type of filamentous fungus will be highly suited as protease producer. Alternatively, the endogenous prtT genes of filamentous fungal cells are inactivated: this type of filamentous fungus is highly suited for the production of any polypeptide native or not which is highly sensitive for protease degradation. The PrtT proteins of the invention provide means for identification of functional homologues in other species.Type: ApplicationFiled: October 11, 2005Publication date: May 8, 2008Inventors: Noel Nicholaas Maria van Peij, Lucie Parenicova