Abstract: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.

Abstract: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.

Abstract: A novel method for separating an irradiated 60Cu or 61Cu or 64Cu respectively from a composition containing 60Ni or 61Ni or 64Ni respectively therein comprises dissolving the irradiated 60Cu or 61Cu or 64Cu in a solvent acid to form an acidic solubilized composition, feeding the acidic solubilized composition onto an ion exchange column and removing an eluent comprising 60Ni or 61Ni or 64Ni ions. In an aspect the eluent is further processed for 60Ni or 61Ni or 64Ni recovery and recycling to prepare future targets. In an aspect 60Cu or 61Cu or 64Cu respectively is temporarily trapped into the ion exchange column resin and held for subsequent recovery by addition of 0.5 N HCl to elute out the 60Cu or 61Cu or 64Cu for further use or labeling. An enhanced process for labeling compounds with highly purified 60Cu, 61Cu or 64Cu comprises loading 60Cu, 61Cu and 64Cu elute onto a concentrating cartridge, collecting the 0.

Abstract: An automated process for preparing and recovering 76Br, 77Br and 124I comprises (I) bombarding enriched 76 or 77Se or enriched 124Te with a beam of protons on a targeted disk respectively to produce 76Br, 77Br and 124I respectively wherein the target is selected from (a) a round tungsten disk with a depression at its center and (b) an inclined target having about a 20° inclination with respect to the beam direction and (II) recovering the 76Br, 77Br and 124I in an automated process comprising by placing the irradiated target face up in a quartz tube in the center of a high temperature furnace utilizing a target holder and heating the irradiated target sufficient to release and recover 76Br, 77Br and 124I therefrom.

Abstract: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.