Abstract: Methods of treatment and prevention of diseases associated with release of neutrophil elastase and IL-8 by administration of TFPI and analogs of TFPI are disclosed. Methods of determining efficacy of treatment with TFPI, patient's responsiveness to treatment with TFPI, and the ultimate determination of patient prognosis are also disclosed.

Abstract: The present invention provides optionally substituted compounds of the formula I or salts thereof; wherein R1 is O or S when double bonded to the ring or is OH, SH, or a protected equivalent, when single bonded to the ring, R2 is hydrogen or more preferably an C1-C10 organic group attached by a carbon atom, X is H, O, OO, S or SS R3 is absent where X?H, is hydrogen or is a hydroxyl or thiol protecting group, R4 is a hetero- or preferably homo-cyclic aryl group, optionally substituted with a further group R5 and groups T1 are each, independently, absent, hydrogen or an S—R6 group, where any/each R6 is independently an organic group of molecular weight up to around 500 amu. The invention further provides a method for the synthesis of such compounds and a method of treatment comprising administering such compounds to a mammalian subject.

Abstract: Compositions consisting of C1 inhibitor muteins having biological activity similar to C1 inhibitor, but with enhanced resistance to proteolytic cleavage thus rendering such muteins suitable as anti inflammatory agents, preferably for the treatment or prevention of sepsis.