Patents by Inventor Lucien Bovet
Lucien Bovet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230397649Abstract: An aerosol-generating substrate for a heated aerosol-generating article is provided, the aerosol-generating substrate including: homogenised tobacco material, the homogenised tobacco material including dried green tobacco material, an aerosol former, and a binder, the homogenised tobacco material having an aerosol former content of between 5 percent and 55 percent by weight on a dry weight basis. A dried green tobacco material for forming an aerosol-generating substrate for an aerosol-generating article, and a method of producing dried green tobacco material for the aerosol-generating substrate, are also provided.Type: ApplicationFiled: October 29, 2021Publication date: December 14, 2023Applicant: Philip Morris Products S.A.Inventors: Lucien BOVET, Simon GOEPFERT, Aurore HILFIKER, Delphine LANGLET
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Publication number: 20230200344Abstract: There is described herein a plant cell (i) a polynucleotide comprising, consisting or consisting essentially of a sequence having at least 60% sequence identity to SEQ ID NO: 1 (NtSULTR3;1A-S), SEQ ID NO: 3 (NtSULTR3;1A-T), SEQ ID NO: 5 (NtSULTR3;1B-S), SEQ ID NO: 7 (NtSULTR3;1B-T), SEQ ID NO: 15 (NtSULTR3;3-T), SEQ ID NO: 17 (NtSULTR3;4A-S), SEQ ID NO: 19 (NtSULTR3;4A-T) or SEQ ID NO: 23 (NtSULTR3;4B-T); (ii) a polypeptide encoded by the polynucleotide set forth in (i); (iii) a polypeptide comprising, consisting or consisting essentially of a sequence having at least 87% sequence identity to SEQ ID NO: 2 (NtSULTR3;1A-S) or at least 87% sequence identity to SEQ ID NO: 4 (NtSULTR3;1A-T) or at least 87% sequence identity to SEQ ID NO: 6 (NtSULTR3;1B-S), or at least 88% sequence identity to SEQ ID NO: 8 (NtSULTR3;1B-T), or at least 70% sequence identity to SEQ ID NO: 16 (NtSULTR3;3-T), or at least 84% sequence identity to SEQ ID NO: 18 (NtSULTR3;4A-S) or at least 79% sequence identity to SEQ ID NO: 20 (NtSULTR3;Type: ApplicationFiled: September 28, 2020Publication date: June 29, 2023Inventor: Lucien Bovet
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Patent number: 11685929Abstract: There is described herein a mutant, non-naturally occurring or transgenic plant or part thereof having reduced expression of the gene encoding Terminal Flower 1 (TFL1) or reduced activity of the protein encoded by TFL1, said TFL1 comprising, consisting or consisting essentially of (i) a polynucleotide sequence comprising, consisting or consisting essentially of a sequence having at least 72% sequence identity to SEQ ID NO:7 or SEQ ID NO:8 or SEQ ID NO:10 or SEQ ID NO:11 or SEQ ID NO:19 or SEQ ID NO:20; or (ii) a polypeptide encoded by the polynucleotide set forth in (i); or (iii) a polypeptide having at least 72% sequence identity to SEQ ID NO:9 or SEQ ID NO:12 or SEQ ID NO:21; wherein the expression or activity of the polynucleotide or the polypeptide set forth in (i), (ii) or (iii) is reduced as compared to a control plant in which the expression or activity of the polynucleotide or the polypeptide set forth in (i), (ii) or (iii) has not been reduced.Type: GrantFiled: December 15, 2017Date of Patent: June 27, 2023Assignee: Philip Morris Products S.A.Inventors: Lucien Bovet, Simon Goepfert, Helene Laparra
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Publication number: 20230172258Abstract: The invention relates to a method for treating tobacco material, the method comprising: o fermenting the tobacco material to obtain treated tobacco material, including: #incubating the tobacco material under anaerobic conditions; #applying a pressure to the tobacco material comprised between 1000 kilograms per square meter and 4000 kilograms per square meter; #keeping the moisture content of the tobacco material comprised between 25 percent in weight and 40 percent in weight of the total weight of the tobacco material; o wherein the fermenting lasts at least one month.Type: ApplicationFiled: May 7, 2021Publication date: June 8, 2023Inventors: Michel Philippe Blanc, Lucien Bovet
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Patent number: 11666082Abstract: Provided are modified tobacco plants having reduced nitrate levels and tobacco products generated from the modified tobacco plants having reduced tobacco specific nitrosamines (TSNAs).Type: GrantFiled: September 23, 2015Date of Patent: June 6, 2023Assignees: Philip Morris Products S.A., North Carolina State UniversityInventors: Jianli Lu, Ramsey S. Lewis, Ralph Dewey, Lucien Bovet
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Patent number: 11591609Abstract: There is described herein a plant cell comprising: (i) a polynucleotide comprising, consisting or consisting essentially of a sequence having at least 95% sequence identity to SEQ ID NO: 1 or SEQ ID NO: 3 or SEQ ID NO: 9 or SEQ ID NO: 11 or SEQ ID NO: 17 or SEQ ID NO: 19 or SEQ ID NO: 21 or SEQ ID NO: 23; or a polynucleotide comprising, consisting or consisting essentially of a sequence having at least 80% sequence identity to SEQ ID NO: 5 or SEQ ID NO: 7 or SEQ ID NO: 13 or SEQ ID NO: 15; (ii) a polypeptide encoded by the polynucleotide set forth in (i); (iii) a polypeptide comprising, consisting or consisting essentially of a sequence having at least 94% sequence identity to SEQ ID NO: 2; or at least 93% sequence identity to SEQ ID NO: 4; or least 95% sequence identity to SEQ ID NO: 6; or at least 96% sequence identity to SEQ ID NO: 8; or at least 93% sequence identity to SEQ ID NO: 10 or SEQ ID NO: 12; or at least 95% sequence identity to SEQ ID NO: 14; or at least 96% sequence identity to SEQ ID NO: 16; oType: GrantFiled: March 27, 2019Date of Patent: February 28, 2023Assignee: Philip Morris Products S.A.Inventors: Aurore Hilfiker, Lucien Bovet
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Publication number: 20220348944Abstract: There is described herein a plant cell comprising: (i) a polynucleotide comprising, consisting or consisting essentially of a sequence having at least 81% sequence identity to SEQ ID NO: 5 (NtINV4-S) or at least 62% sequence identity to SEQ ID NO: 7 (NtINV4-T); (ii) a polypeptide encoded by the polynucleotide set forth in (i); (iii) a polypeptide comprising, consisting or consisting essentially of a sequence having at least 85% sequence identity to SEQ ID NO: 6 (NtINV4-S) or at least 85% sequence identity to SEQ ID NO: 8 (NtINV4-T); or (iv) a construct, vector or expression vector comprising the isolated polynucleotide set forth in (i), wherein said plant cell comprises at least one modification which modulates (a) the expression or activity of the polynucleotide or (b) the expression or activity of the polynucleotide the polypeptide, as compared to a control plant cell in which the expression or activity of the polynucleotide or polypeptide has not been modified.Type: ApplicationFiled: September 28, 2020Publication date: November 3, 2022Inventors: Lucien Bovet, Aurore Hilfiker
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Publication number: 20220186242Abstract: A plant cell comprising: (a) a polynucleotide sequence encoding a nitrate reductase polypeptide comprising a contiguous polypeptide sequence of SEQ ID NO: 5 or SEQ ID NO: 7, wherein methionine is substituted for an amino acid that reduces nitrate reductase activity in the plant cell as compared to a control plant cell; (b) a polypeptide sequence encoded by the polynucleotide sequence set forth in (a); or (c) a construct, vector or expression vector comprising the polynucleotide sequence set forth in (b).Type: ApplicationFiled: December 16, 2019Publication date: June 16, 2022Inventors: Lucien Bovet, Prisca Campanoni, Simon Goepfert
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Patent number: 11213004Abstract: There is described herein a mutant plant or part thereof having at least partially reduced expression or activity of at least two heavy metal ATPases (HMAs), said two HMAs comprising, consisting or consisting essentially of: (i) polypeptides having at least 65% sequence identity to SEQ ID NO:1 and SEQ ID NO:2; (ii) polynucleotides encoding the polypeptides set forth in (i); or (iii) polynucleotides having at least 65% sequence identity to SEQ ID NO:3 and SEQ ID NO:4 encoding HMAs; wherein the expression or activity of one of the HMAs set forth in (i) or (ii) or (iii) is partially reduced or lost and the expression or activity of one of the HMAs set forth in (i) or (ii) or (iii) is lost as compared to a control plant; and wherein the mutant plant or part thereof exhibits at least a 27% reduction, as compared to the control plant, in the accumulation of cadmium in leaf when the mutant plant is grown in the field in the presence of naturally or non-naturally occurring cadmium.Type: GrantFiled: January 27, 2017Date of Patent: January 4, 2022Assignee: Philip Morris Products S.A.Inventors: Lucien Bovet, Verena Liedschulte
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Publication number: 20210115459Abstract: There is described herein a plant cell comprising: (i) a polynucleotide comprising, consisting or consisting essentially of a sequence having at least 95% sequence identity to SEQ ID NO: 1 or SEQ ID NO: 3 or SEQ ID NO: 9 or SEQ ID NO: 11 or SEQ ID NO: 17 or SEQ ID NO: 19 or SEQ ID NO: 21 or SEQ ID NO: 23; or a polynucleotide comprising, consisting or consisting essentially of a sequence having at least 80% sequence identity to SEQ ID NO: 5 or SEQ ID NO: 7 or SEQ ID NO: 13 or SEQ ID NO: 15; (ii) a polypeptide encoded by the polynucleotide set forth in (i); (iii) a polypeptide comprising, consisting or consisting essentially of a sequence having at least 94% sequence identity to SEQ ID NO: 2; or at least 93% sequence identity to SEQ ID NO: 4; or least 95% sequence identity to SEQ ID NO: 6; or at least 96% sequence identity to SEQ ID NO: 8; or at least 93% sequence identity to SEQ ID NO: 10 or SEQ ID NO: 12; or at least 95% sequence identity to SEQ ID NO: 14; or at least 96% sequence identity to SEQ ID NO: 16; oType: ApplicationFiled: March 27, 2019Publication date: April 22, 2021Inventors: Aurore Hilfiker, Lucien Bovet
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Publication number: 20210115461Abstract: The present invention discloses the polynucleotide sequences of genes encoding aspartate transaminase (AAT) from Nicotiana tabacum and the modulation of their expression.Type: ApplicationFiled: March 27, 2019Publication date: April 22, 2021Inventors: Aurore Hilfiker, Lucien Bovet
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Patent number: 10883114Abstract: There is described herein a mutant, non-naturally occurring or transgenic plant or part thereof having reduced expression or activity of asparagine synthetase, said asparagine synthetase comprising, consisting or consisting essentially of: (i) a polynucleotide sequence comprising, consisting or consisting essentially of a sequence having at least 90% sequence identity to SEQ ID NO:1 or at least 72% sequence identity to SEQ ID NO:3 or SEQ ID NO:5 or SEQ ID NO:7; or (ii) a polypeptide encoded by the polynucleotide set forth in (i); or (iii) a polypeptide having at least 78% sequence identity to SEQ ID NO:2 or SEQ ID NO:4 or SEQ ID NO:6 or SEQ ID NO:8; wherein the expression or activity of the asparagine synthetase set forth in (i), (ii) or (iii) is reduced as compared to a control plant.Type: GrantFiled: September 6, 2016Date of Patent: January 5, 2021Assignee: Philip Morris Products S.A.Inventor: Lucien Bovet
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Publication number: 20200208164Abstract: There is described herein a mutant, non-naturally occurring or transgenic plant or part thereof having reduced expression of the gene encoding Terminal Flower 1 (TFL1) or reduced activity of the protein encoded by TFL1, said TFL1 comprising, consisting or consisting essentially of (i) a polynucleotide sequence comprising, consisting or consisting essentially of a sequence having at least 72% sequence identity to SEQ ID NO:7 or SEQ ID NO:8 or SEQ ID NO:10 or SEQ ID NO:11 or SEQ ID NO:19 or SEQ ID NO:20; or (ii) a polypeptide encoded by the polynucleotide set forth in (i); or (iii) a polypeptide having at least 72% sequence identity to SEQ ID NO:9 or SEQ ID NO:12 or SEQ ID NO:21; wherein the expression or activity of the polynucleotide or the polypeptide set forth in (i), (ii) or (iii) is reduced as compared to a control plant in which the expression or activity of the polynucleotide or the polypeptide set forth in (i), (ii) or (iii) has not been reduced.Type: ApplicationFiled: December 15, 2017Publication date: July 2, 2020Inventors: Lucien Bovet, Simon Goepfert, Helene Laparra
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Patent number: 10563215Abstract: In one aspect, there is provided a mutant, non-naturally occurring or transgenic plant cell comprising: (i) a polynucleotide comprising, consisting or consisting essentially of a sequence encoding a member of the CLC family of chloride channels and having at least 60% sequence identity to SEQ ID NO:1 or SEQ ID NO:2 or SEQ ID NO:3 or SEQ ID NO:4 or SEQ ID NO:10 or SEQ ID NO:11; (ii) a polypeptide encoded by the polynucleotide set forth in (i); (iii) a polypeptide comprising, consisting or consisting essentially of a sequence encoding a member of the CLC family of chloride channels and having at least 60% sequence identity to SEQ ID NO:5 or SEQ ID NO:6 or SEQ ID NO:7 or SEQ ID NO:12 or SEQ ID NO:13 or SEQ ID NO:14; or (iv) a construct, vector or expression vector comprising the isolated polynucleotide set forth in (i); and wherein the expression or activity of the polynucleotide or the polypeptide is modulated as compared to a control plant and wherein the nitrate levels in the mutant, non-naturally occurring oType: GrantFiled: December 19, 2013Date of Patent: February 18, 2020Assignee: Philip Morris Products S.A.Inventors: Lucien Bovet, Prisca Campanoni
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Publication number: 20190387702Abstract: There is described herein a mutant plant or part thereof having at least partially reduced expression or activity of at least two heavy metal ATPases (HMAs), said two HMAs comprising, consisting or consisting essentially of: (i) polypeptides having at least 65% sequence identity to SEQ ID NO:1 and SEQ ID NO:2; (ii) polynucleotides encoding the polypeptides set forth in (i); or (iii) polynucleotides having at least 65% sequence identity to SEQ ID NO:3 and SEQ ID NO:4 encoding HMAs; wherein the expression or activity of one of the HMAs set forth in (i) or (ii) or (iii) is partially reduced or lost and the expression or activity of one of the HMAs set forth in (i) or (ii) or (iii) is lost as compared to a control plant; and wherein the mutant plant or part thereof exhibits at least a 27% reduction, as compared to the control plant, in the accumulation of cadmium in leaf when the mutant plant is grown in the field in the presence of naturally or non-naturally occurring cadmium.Type: ApplicationFiled: January 27, 2017Publication date: December 26, 2019Inventors: Lucien Bovet, Verena Liedschulte
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Patent number: 10501732Abstract: There is disclosed a mutant, non-naturally occurring or transgenic plant cell comprising: (i) a polynucleotide comprising, consisting or consisting essentially of a sequence encoding a threonine synthase and having at least 90% sequence identity to SEQ ID NO:1, SEQ ID NO:2 or SEQ ID NO:3 or at least 87% sequence identity to SEQ ID NO:4, or SEQ ID NO:5; (ii) a polypeptide encoded by any one of said polynucleotides set forth in (i); or (iii) a polypeptide having at least 95% sequence identity to SEQ ID NO:6, SEQ ID NO:7 or SEQ ID NO:8; or (iv) a construct, vector or expression vector comprising the polynucleotide as set forth in (i).Type: GrantFiled: August 31, 2012Date of Patent: December 10, 2019Assignee: Philip Morris Products S.A.Inventors: Lucien Bovet, Nicolas Sierro
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Patent number: 10415050Abstract: The present invention relates to a mutant, non-naturally occurring or transgenic tobacco plant cell comprising: (i) a polynucleotide comprising, consisting or consisting essentially of a sequence encoding a functional nicotine N-demethylase and having at least 95% sequence identity to SEQ ID NO:2; (ii) a polypeptide encoded by the polynucleotide set forth in (i); (iii) a polypeptide comprising, consisting or consisting essentially of a sequence encoding a nicotine N-demethylase and having at least 95% sequence identity to SEQ ID NO:3; or (iv) a construct, vector or expression vector comprising the isolated polynucleotide set forth in (i), and wherein the expression or activity of said nicotine demethylase is reduced as compared to a control tobacco plant cell in which the expression or activity of said nicotine demethylase has not been reduced.Type: GrantFiled: May 7, 2015Date of Patent: September 17, 2019Assignee: Philip Morris Products S.A.Inventors: Verena Liedschulte, Simon Goepfert, Lucien Bovet, Nicolas Sierro
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Publication number: 20190169628Abstract: There is described herein a mutant, non-naturally occurring or transgenic plant or part thereof having reduced expression or activity of asparagine synthetase, said asparagine synthetase comprising, consisting or consisting essentially of: (i) a polynucleotide sequence comprising, consisting or consisting essentially of a sequence having at least 90% sequence identity to SEQ ID NO:1 or at least 72% sequence identity to SEQ ID NO:3 or SEQ ID NO:5 or SEQ ID NO:7; or (ii) a polypeptide encoded by the polynucleotide set forth in (i); or (iii) a polypeptide having at least 78% sequence identity to SEQ ID NO:2 or SEQ ID NO:4 or SEQ ID NO:6 or SEQ ID NO:8; wherein the expression or activity of the asparagine synthetase set forth in (i), (ii) or (iii) is reduced as compared to a control plant.Type: ApplicationFiled: September 6, 2016Publication date: June 6, 2019Inventor: Lucien BOVET
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Publication number: 20170303582Abstract: Provided are modified tobacco plants having reduced nitrate levels and tobacco products generated from the modified tobacco plants having reduced tobacco specific nitrosamines (TSNAs).Type: ApplicationFiled: September 23, 2015Publication date: October 26, 2017Applicants: PHILIP MORRIS PRODUCTS S.A., NORTH CAROLINA STATE UNIVERSITYInventors: Jianli Lu, Ramsey S. Lewis, Ralph Dewey, Lucien Bovet
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Publication number: 20170265516Abstract: The invention provides protease genes which are regulated in a specific manner during curing of tobacco plants material and which affect the flavour of cured tobacco.Type: ApplicationFiled: July 16, 2015Publication date: September 21, 2017Inventors: Lucien Bovet, Dion Florack, James Battey