Patents by Inventor Lucille J. Cole

Lucille J. Cole has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel antifungal substances and process for their production
    Patent number: 5028537
    Abstract: There is disclosed a series of macrolides isolated from the fermentation broth of a microorganism identified as MA-5000 which morphological analysis reveals to be a strain of Streptomyces hygroscopicus. The compounds' structures are present based upon analytical studies. The compounds have antifungal activity.
    Type: Grant
    Filed: June 6, 1988
    Date of Patent: July 2, 1991
    Assignee: Merck & Co. Inc.
    Inventors: Richard W. Burg, Otto D. Hensens, Jerrold M. Liesch, Sebastian Hernandez, Lucille J. Cole
  • Antifungal substances and process for their production
    Patent number: 4575500
    Abstract: There is disclosed a series of macrolides isolated from the fermentation broth of a microorganism identified as MA-5000 which morphological analysis reveals to be a strain of Streptomyces hygroscopicus. The compound's structure is presented based upon analytical studies. The compound has antifungal activity.
    Type: Grant
    Filed: March 26, 1984
    Date of Patent: March 11, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Richard W. Burg, Lucille J. Cole, Sebastian Hernandez
  • Dopamine .beta.-hydroxylase inhibitors
    Patent number: 4487761
    Abstract: Two fermentation isolates, C.sub.7 H.sub.9 NO.sub.4 and C.sub.6 H.sub.7 NO.sub.3, presumably trihydroxy, methyl-pyridine derivatives, are inhibitors of dopamine .beta.-hydroxylase. These natural product compounds are produced by fermentation of Streptoverticillium hiroshimense and each may prove useful as antihypertensive agents.
    Type: Grant
    Filed: April 5, 1982
    Date of Patent: December 11, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Lucille J. Cole, Leeyan Huang, Jerrold M. Liesch
  • Process for the separation of antibiotic macrolides
    Patent number: 4160083
    Abstract: This case relates to a novel process which aids in the isolation and purification of novel compounds which are produced by the microorganism, Streptomyces avermitilis. The process described herein utilizes a hydroxypropyl Sephadex column chromatographic step in the isolation of the compounds from broth. The compounds which are isolated and purified are described generically s C-076 and have significant parasiticidal activity.
    Type: Grant
    Filed: October 3, 1977
    Date of Patent: July 3, 1979
    Assignee: Merck & Co., Inc.
    Inventor: Lucille J. Cole
  • Acid degradation products of boromycin
    Patent number: 4102997
    Abstract: A novel mixture of degradation products of boromycin is prepared by treating boromycin with acid. This mixture of compounds has anticoccidial activity and is useful for controlling cecal and/or intestinal coccidiosis when administered in minor quantities to animals, in particular to poultry, usually in admixture with animal sustenance.
    Type: Grant
    Filed: November 22, 1976
    Date of Patent: July 25, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Irving Putter, Lucille J. Cole