Patents by Inventor Lucio Merlini

Lucio Merlini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Camptothecin derivatives having antitumor activity
    Publication number: 20010008939
    Abstract: Camptothecin derivatives of camptothecin of formula (I) 1
    Type: Application
    Filed: December 22, 2000
    Publication date: July 19, 2001
    Applicant: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A..
    Inventors: Sergio Penco, Lucio Merlini, Paolo Carminati, Franco Zunino
  • Camptothecin derivatives having antitumor activity
    Patent number: 6242457
    Abstract: Camptothecin derivatives of camptothecin of formula (I) wherein the groups R1, R2 and R3 are as defined in the description are disclosed. The compounds of formula (I) are endowed with antitumor activity and show a good therapeutic index. Processes for the preparation of the compounds of formula (I) and their use in the preparation of medicaments useful in the treatment of tumors, viral infections and antiplasmodium falciparum are also disclosed.
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: June 5, 2001
    Assignees: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A., Istituo Nazionale per lo Studio e la Cura dei Tumori
    Inventors: Sergio Penco, Lucio Merlini, Paolo Carminati, Franco Zunino
  • 7-Substituted camptothecin derivatives and methods for inhibiting the growth of tumor cells therewith
    Patent number: 6130227
    Abstract: 20S-Camptothecin derivatives in which the 7-position bears as a substituent --CN, --CH(CN)R.sub.4, --CH.dbd.C(CN)R.sub.4, --C(.dbd.NOH)NH.sub.2, --C(.dbd.NH)NH.sub.2, --CH.dbd.C(NO.sub.2)R.sub.4, --CH(CN)R.sub.5, --CH(CH.sub.2 NO.sub.2)R.sub.5, tetrazol-5-yl, 4,5-dihydrooxazol-2-yl, or 1,2,4-oxadiazolin-3-yl-5-one. These compounds are active as topoisomerase I inhibitors, and can be used as antitumor drugs.
    Type: Grant
    Filed: August 20, 1998
    Date of Patent: October 10, 2000
    Assignee: Istituto Nazional per Lo Studio e la Cura Dei Tumori
    Inventors: Lucio Merlini, Sergio Penco, Franco Zunino
  • Substituted iminoderivatives of dihydrobenzopyran and dihydrobenzothiopyran
    Patent number: 4497820
    Abstract: Substituted imino derivatives of 4 H-2, 3-dihydrobenzopyran and 4 H-2, 3-dihydrobenzothiopyran, and pharmaceutical compositions containing them. The compounds are active on the central nervous system, in particular as central nervous system depressants, i.e., sedatives, anticonvulsive agents, tranquilizers and sleep-inducing agents.
    Type: Grant
    Filed: May 4, 1983
    Date of Patent: February 5, 1985
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Lucio Merlini, Alessandro Rossi, Metilde Buonamici