Patents by Inventor Ludek Meca

Ludek Meca has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing methyl (Z)-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene)oxindole-6-carboxylate (intedanib, nintedanib)
    Patent number: 10125122
    Abstract: The invention relates to a method of synthesizing methyl (Z)-3-[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl] amino]phenylmethylene)-oxindole-6-carboxylate of formula (1), known under the generic name of intedanib or nintedanib. The present method comprises a) a reaction of methyl oxindole-6-carboxylate with acetic anhydride at a temperature of 130-140° C.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: November 13, 2018
    Assignee: Zentiva k.s.
    Inventor: Ludek Meca
  • METHOD FOR PREPARING METHYL (Z)-3-[[4-[METHYL[2-(4-METHYL-1-PIPERAZINYL)ACETYL]AMINO]PHEHYL]AMINO]PHENYLMETHYLENE)-OXINDOLE-6-CARBOXYLATE (INTEDANIB, NINTEDANIB)
    Publication number: 20180215735
    Abstract: The invention relates to a method of synthesizing methyl (Z)-3-[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl] amino]phenylmethylene)-oxindole-6-carboxylate of formula (1), known under the generic name of intedanib or nintedanib. The present method comprises a) a reaction of methyl oxindole-6-carboxylate with acetic anhydride at a temperature of 130-140° C.
    Type: Application
    Filed: July 28, 2016
    Publication date: August 2, 2018
    Applicant: Zentiva k.s.
    Inventor: Ludek MECA
  • Catalysts for metathesis reactions
    Patent number: 8507398
    Abstract: Catalysts for metathesis reactions, in particular for the metathesis of nitrile rubber, are provided.
    Type: Grant
    Filed: August 18, 2008
    Date of Patent: August 13, 2013
    Assignee: LANXESS Deutschland GmbH
    Inventors: Ludek Meca, Lubica Triscikova, Heinz Berke, Kirsten Langfeld, Martin Schneider, Oskar Nuyken, Werner Obrecht
  • CATALYSTS FOR METATHESIS REACTIONS
    Publication number: 20090076226
    Abstract: Novel catalysts for metathesis reactions, in particular for the metathesis of nitrile rubber, are provided.
    Type: Application
    Filed: August 18, 2008
    Publication date: March 19, 2009
    Applicant: LANXESS DEUTSCHLAND GMBH
    Inventors: Ludek Meca, Lubica Triscikova, Heinz Berke, Kirsten Langfeld, Martin Schneider, Oskar Nuyken, Werner Obrecht
  • Method for the degradation of nitrile rubber by metathesis in the presence of ruthenium- or osmium-based catalysts
    Patent number: 7470750
    Abstract: A novel process for the degradation of nitrile rubber by metathesis using ruthenium- or osmium-based catalysts which have both a substituted or unsubstituted imidazolidine ligand and a carbene ligand bearing a phosphonium radical is provided.
    Type: Grant
    Filed: August 25, 2006
    Date of Patent: December 30, 2008
    Assignee: LANXESS Deutschland GmbH
    Inventors: Werner Obrecht, Julia Maria Müller, Oskar Nuyken, Heinz Berke, Ludek Meca, Lubica Triscikova
  • Method for the degradation of nitrile rubber by metathesis in the presence of ruthenium- or osmium-based catalysts
    Publication number: 20070049700
    Abstract: A novel process for the degradation of nitrile rubber by metathesis using ruthenium- or osmium-based catalysts which have both a substituted or unsubstituted imidazolidine ligand and a carbene ligand bearing a phosphonium radical is provided.
    Type: Application
    Filed: August 25, 2006
    Publication date: March 1, 2007
    Inventors: Werner Obrecht, Julia Muller, Oskar Nuyken, Heinz Berke, Ludek Meca, Lubica Triscikova