Patents by Inventor Ludi Zhang

Ludi Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for Expanding Hepatocyte in Vitro and Application
    Publication number: 20210340494
    Abstract: Provided are a method for expanding a hepatocyte in vitro and an application thereof. A culture system is provided for reprogramming a human hepatocyte into a proliferating intermediate-state cell between a mature hepatocyte and a liver progenitor cell. The liver repopulation ability of the system was verified in animals. The method does not require the introduction of an exogenous gene into a hepatocyte, and the expansion of the hepatocyte can be realized by conventional culture. The obtained hepatocyte can be passaged, and can be cultured to maturation to obtain a functional mature human hepatocyte.
    Type: Application
    Filed: August 14, 2019
    Publication date: November 4, 2021
    Inventors: Lijian Hui, Ludi Zhang, Kun Zhang
  • Human hepatocyte-like cells and uses thereof
    Patent number: 9623048
    Abstract: The present invention relates to hepatocyte-like cells. Also disclosed are methods of making the cells and using the cells.
    Type: Grant
    Filed: February 8, 2014
    Date of Patent: April 18, 2017
    Assignee: SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCES
    Inventors: Lijian Hui, Pengyu Huang, Ludi Zhang, Yimeng Gao
  • Human Hepatocyte-Like Cells and Uses Thereof
    Publication number: 20150190427
    Abstract: The present invention relates to hepatocyte-like cells. Also disclosed are methods of making the cells and using the cells.
    Type: Application
    Filed: February 8, 2014
    Publication date: July 9, 2015
    Applicant: SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCES
    Inventors: Lijian Hui, Pengyu Huang, Ludi Zhang, Yimeng Gao