Patents by Inventor Ludo E. J. Kennis

Ludo E. J. Kennis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use
    Patent number: 5158952
    Abstract: The present invention relates to novel 3-piperidinyl-1,2-benzisoxazoles having long-acting antipsychotic properties and which are useful in the treatment of warm-blooded animals suffering from psychotic diseases. Methods of preparing said compounds and compositions containing the same.
    Type: Grant
    Filed: October 17, 1989
    Date of Patent: October 27, 1992
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Cornelus G. M. Janssen, Alfonsus G. Knaeps, Ludo E. J. Kennis, Jan Vandenberk
  • 2-aminopyrimidinone derivatives
    Patent number: 5140029
    Abstract: 2-Amino-pyrimidininone derivatives possessing serotonin-antagonistic and antihistaminic properties. Compositions containing these compounds as the active ingredient. Method of treating subjects suffering from diseases and/or disorders associated with the release of neurotransmitters, in particular, a method of treating subjects suffering from sleep disorders with 2-aminopyrimidinone derivatives substituted with a 4-bis(aryl)methylene-1-piperidinyl group; and a method of treating subjects suffering from psychotic diseases and/or disorders with 2-aminopyrimidinone derivatives substituted with a 4-arylcarbonyl-1-piperidinyl, 4-benzazoyl-1-piperidinyl, 4-benzazolyl-1-piperazinyl or 4-indolyl-1-piperidinyl, 4-benzo[b]furanyl-1-piperidinyl or 4-benzo[b]thienyl-1-piperidinyl group.
    Type: Grant
    Filed: January 18, 1991
    Date of Patent: August 18, 1992
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ludo E. J. Kennis, Jan Vandenberk, Jozef M. Boey
  • Antipsychotic 3-piperazinylbenzazole derivatives
    Patent number: 5015740
    Abstract: 3-Piperazinyl-1,2-benzazoles and their pharmaceutically acceptable acid addition salts having useful antipsychotic properties and being useful in the treatment of a variety of disorders in which serotonin and/or dopamine release is of predominant importance.
    Type: Grant
    Filed: June 11, 1990
    Date of Patent: May 14, 1991
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ludo E. J. Kennis, Jan Vandenberk, Josephus C. Mertens
  • 2-aminopyrimidinone derivatives
    Patent number: 5008268
    Abstract: 2-Amino-pyrimidininone derivatives possessing antihistaminic and serotonin-antagonistic properties. Compositions containing these compounds as the active ingredient and a method of treating subjects from allergic diseases.
    Type: Grant
    Filed: December 26, 1989
    Date of Patent: April 16, 1991
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Frans E. Janssens, Ludo E. J. Kennis, Francois M. Sommen, Ann C. J. Dierckx
  • Antipsychotic 3-piperazinylbenzazole derivatives
    Patent number: 4957916
    Abstract: 3-Piperazinyl-1,2-benzazoles and their pharmaceutically acceptable acid addition salts having useful antipsychotic properties and being useful in the treatment of a variety of disorders in which serotonin and/or dopamine release is of predominant importance.
    Type: Grant
    Filed: June 14, 1989
    Date of Patent: September 18, 1990
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ludo E. J. Kennis, Jan Vandenberk, Josephus C. Mertens
  • 4-((Bicyclic heterocyclyl)-methyl and -hetero)-piperidines
    Patent number: 4839374
    Abstract: 4-[Bicyclic heterocyclyl)methyl and -hetero]-piperidines having antihistaminic and serotonin-antagonistic properties which compounds are useful agents in the treatment of allergic diseases.
    Type: Grant
    Filed: September 10, 1987
    Date of Patent: June 13, 1989
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Frans E. Janssens, Ludo E. J. Kennis, Jozef F. Hens, Joseph L. G. Torremans, Gaston S. M. Diels
  • 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
    Patent number: 4804663
    Abstract: 3-Piperdinyl-1,2-benzisothiazoles and 3-piperidinyl-1,2-benzisoxazoles and their pharmaceutically acceptable acid addition salts having useful antipsychotic properties and being useful in the treatment of a variety of complaints in which serotonin release is of predominant importance.
    Type: Grant
    Filed: February 5, 1986
    Date of Patent: February 14, 1989
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ludo E. J. Kennis, Jan Vandenberk
  • 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines
    Patent number: 4695575
    Abstract: 4-[(Bicyclic heterocyclyl)methyl and -hetero]-piperidines having antihistaminic and serotonin-antagonistic properties which compounds are useful agents in the treatment of allergic diseases.
    Type: Grant
    Filed: June 24, 1985
    Date of Patent: September 22, 1987
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Frans E. Janssens, Ludo E. J. Kennis, Jozef F. Hens, Joseph L. G. Torremans, Gaston S. M. Diels
  • Derivatives of hydroxy- or amino-substituted (piperidinylalkyl)quinazolines
    Patent number: 4665075
    Abstract: Novel derivatives of hydroxy- or amino-substituted (piperidinylalkyl)quinazolines which are useful agents in the treatment of warmblooded animals suffering from diseases according to the vascular bed in which excessive serotonin release occurs.
    Type: Grant
    Filed: September 26, 1985
    Date of Patent: May 12, 1987
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Vandenberk, Ludo E. J. Kennis, Josephus C. Mertens
  • [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders
    Patent number: 4581171
    Abstract: Novel [[bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones, wherein the pyrimidinone-ring is embraced within a bicyclic system, being useful compounds in the treatment of psychosomatic disorders.
    Type: Grant
    Filed: September 27, 1984
    Date of Patent: April 8, 1986
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Ludo E. J. Kennis, Jan Vandenberk, Josephus C. Mertens
  • 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones
    Patent number: 4548939
    Abstract: 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones having psychotropic activity.
    Type: Grant
    Filed: October 1, 1984
    Date of Patent: October 22, 1985
    Assignee: Janssen Pharmaceutica N. V.
    Inventors: Ludo E. J. Kennis, Jan Vandenberk, Jozef M. Boey
  • 5-H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one compounds
    Patent number: 4548938
    Abstract: Novel 5H-thiazolo- and 5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one and 3,4-dihydro-2H,6H-pyrimido[2,1-b] [1,3]-thiazin-6-one derivatives, which compounds are useful psychotropic agents.
    Type: Grant
    Filed: February 19, 1985
    Date of Patent: October 22, 1985
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ludo E. J. Kennis, Josephus C. Mertens
  • [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
    Patent number: 4533665
    Abstract: Novel [[bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones, wherein the pyrimidinone-ring is embraced within a bicyclic system, being useful compounds in the treatment of psychosomatic disorders.
    Type: Grant
    Filed: September 27, 1984
    Date of Patent: August 6, 1985
    Assignee: Janssen Pharmaceutica
    Inventors: Ludo E. J. Kennis, Jan Vandenberk, Josephus C. Mertens
  • Pyrimido[2,1-b][1,3]-thiazines
    Patent number: 4529727
    Abstract: Novel 5H-thiazolo- and 5H-1,3,4-thiadiazolo[3,2-a]-pyrimidin-5-one and 3,4-dihydro-2H,6H-pyrimido[2,1-b][1,3]-thiazin-6-one derivatives, which compounds are useful psychotropic agents.
    Type: Grant
    Filed: February 2, 1984
    Date of Patent: July 16, 1985
    Assignee: Janssen Pharmaceutical, N.V.
    Inventors: Ludo E. J. Kennis, Josephus C. Mertens
  • [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
    Patent number: 4485107
    Abstract: Novel [[bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones, wherein the pyrimidinone-ring is embraced within a bicyclic system, being useful compounds in the treatment of psychosomatic disorders.
    Type: Grant
    Filed: July 27, 1983
    Date of Patent: November 27, 1984
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ludo E. J. Kennis, Jan Vandenberk, Josephus C. Mertens
  • Bicyclic pyrimidin-5-one derivatives
    Patent number: 4443451
    Abstract: Novel 5H-thiazolo- and 5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one and 3,4-dihydro-2H,6H-pyrimido[2,1-b] [1,3]-thiazin-6-one derivatives, which compounds are useful psychotropic agents.
    Type: Grant
    Filed: April 21, 1982
    Date of Patent: April 17, 1984
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ludo E. J. Kennis, Josephus C. Mertens
  • Piperazine derivatives
    Patent number: 4377578
    Abstract: Novel 1-substituted 4-(diarylmethyl)piperazine derivatives having antianaphylactic and antihistaminic properties.
    Type: Grant
    Filed: July 24, 1981
    Date of Patent: March 22, 1983
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jan Vandenberk, Ludo E. J. Kennis, Marcel J. M. C. Van der Aa, Albert H. M. Th. Van Heertum
  • Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives
    Patent number: 4342870
    Abstract: Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives, wherein the piperidine ring is substituted with an aroyl radical or a functional derivative thereof, said compounds being potent serotonin-antagonists.
    Type: Grant
    Filed: September 29, 1980
    Date of Patent: August 3, 1982
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ludo E. J. Kennis, Josephus C. Mertens
  • 1,3-Dihydro-1-[(1-piperidinyl)alkyl]-2H-benzimidazol-2-one derivatives
    Patent number: 4254127
    Abstract: Novel 1,3-dihydro-1-[(1-piperidinyl)alkyl]-2H-benzimidazol-2-one derivatives which compounds are potent serotonin-antagonists and central nervous system depressants, having utility as antiemetic, neuroleptic and anti-congestive agents.
    Type: Grant
    Filed: April 3, 1980
    Date of Patent: March 3, 1981
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jan Vandenberk, Ludo E. J. Kennis, Albert H. M. Th. Van Heertum, Marcel J. M. C. Van der Aa
  • Piperazine derivatives
    Patent number: 4250176
    Abstract: Novel 1-substituted 4-(diarylmethyl)piperazine derivatives having antianaphylactic and antihistaminic properties, in which the 1-substituent is optionally substituted 2(3H) benzimidazol-2-one, 2(3H) benzothiazol-2-one, or 2(3H) benzoxazol-2-one.
    Type: Grant
    Filed: June 18, 1979
    Date of Patent: February 10, 1981
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Vandenberk, Ludo E. J. Kennis, Marcel J. M. C. Van der Aa, Albert H. M. T. Van Heertum