Patents by Inventor Ludovic Gillet
Ludovic Gillet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240355604Abstract: Systems and methods are disclosed for analyzing a sample using overlapping precursor isolation windows. A mass analyzer of a tandem mass spectrometer is instructed to select and fragment at least two overlapping precursor isolation windows across a precursor ion mass range of a sample using a processor. The tandem mass spectrometer includes a mass analyzer that allows overlapping precursor isolation windows across the mass range of the sample.Type: ApplicationFiled: July 1, 2024Publication date: October 24, 2024Applicants: DH Technologies Development Pte. Ltd., ETH ZurichInventors: Ronald F. Bonner, Stephen A. Tate, Rudolf Aebersold, Pedro Jose Navarro Alvarez, Oliver Rinner, Lukas Reiter, Ludovic Gillet
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Patent number: 12033839Abstract: Systems and methods are disclosed for analyzing a sample using overlapping precursor isolation windows. A mass analyzer of a tandem mass spectrometer is instructed to select and fragment at least two overlapping precursor isolation windows across a precursor ion mass range of a sample using a processor. The tandem mass spectrometer includes a mass analyzer that allows overlapping precursor isolation windows across the mass range of the sample.Type: GrantFiled: December 1, 2021Date of Patent: July 9, 2024Assignees: DH Technologies Development Pte. Ltd., ETH ZürichInventors: Ronald F. Bonner, Stephen A. Tate, Rudolf Aebersold, Pedro Jose Navarro Alvarez, Oliver Rinner, Lukas Reiter, Ludovic Gillet
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Publication number: 20220181132Abstract: Systems and methods are disclosed for analyzing a sample using overlapping precursor isolation windows. A mass analyzer of a tandem mass spectrometer is instructed to select and fragment at least two overlapping precursor isolation windows across a precursor ion mass range of a sample using a processor. The tandem mass spectrometer includes a mass analyzer that allows overlapping precursor isolation windows across the mass range of the sample.Type: ApplicationFiled: December 1, 2021Publication date: June 9, 2022Inventors: Ronald F. Bonner, Stephen A. Tate, Rudolf Aebersold, Pedro Jose Navarro Alvarez, Oliver Rinner, Lukas Reiter, Ludovic Gillet
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Patent number: 11222775Abstract: Systems and methods are disclosed for analyzing a sample using overlapping precursor isolation windows. A mass analyzer of a tandem mass spectrometer is instructed to select and fragment at least two overlapping precursor isolation windows across a precursor ion mass range of a sample using a processor. The tandem mass spectrometer includes a mass analyzer that allows overlapping precursor isolation windows across the mass range of the sample.Type: GrantFiled: June 24, 2019Date of Patent: January 11, 2022Assignees: DH Technologies Development Pte. Ltd.Inventors: Ronald F. Bonner, Stephen A. Tate, Rudolf Aebersold, Pedro Jose Navarro Alvarez, Oliver Rinner, Lukas Reiter, Ludovic Gillet
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Publication number: 20190311892Abstract: Systems and methods are disclosed for analyzing a sample using overlapping precursor isolation windows. A mass analyzer of a tandem mass spectrometer is instructed to select and fragment at least two overlapping precursor isolation windows across a precursor ion mass range of a sample using a processor. The tandem mass spectrometer includes a mass analyzer that allows overlapping precursor isolation windows across the mass range of the sample.Type: ApplicationFiled: June 24, 2019Publication date: October 10, 2019Inventors: Ronald F. Bonner, Stephen A. Tate, Rudolf Aebersold, Pedro Jose Navarro Alvarez, Oliver Rinner, Lukas Reiter, Ludovic Gillet
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Publication number: 20170032948Abstract: Systems and methods are disclosed for analyzing a sample using overlapping precursor isolation windows. A mass analyzer of a tandem mass spectrometer is instructed to select and fragment at least two overlapping precursor isolation windows across a precursor ion mass range of a sample using a processor. The tandem mass spectrometer includes a mass analyzer that allows overlapping precursor isolation windows across the mass range of the sample.Type: ApplicationFiled: October 14, 2016Publication date: February 2, 2017Inventors: Ronald F. Bonner, Stephen A. Tate, Rudolf Aebersold, Pedro Jose Navarro Alvarez, Oliver Rinner, Lukas Reiter, Ludovic Gillet
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Publication number: 20160225594Abstract: Systems and methods are disclosed for detecting compounds in a sample using a tandem mass spectrometer. A sample comprising a plurality of detectable compounds that have been separated in time over a time interval is introduced into a tandem mass spectrometer. A sample product ion spectra is obtained. The presence of one or more known compounds of interest in the sample product ion spectra is determined. A compound is identified as present in the sample if the score associated with said compound meets a threshold value set as indicative of the likely presence of the compound in the sample.Type: ApplicationFiled: April 13, 2016Publication date: August 4, 2016Inventors: Ronald F. Bonner, Stephen A. Tate, Rudolf Aebersold, Pedro Jose Navarro Alvarez, Oliver Rinner, Lukas Reiter, Ludovic Gillet
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Patent number: 9343278Abstract: Systems and methods are disclosed for quantitating detectable compounds of a sample. Sample product ion spectra are received for each mass selection window for each time step. The received sample product ion spectra are searched for the presence of known compounds of interest with known product ion spectra by retrieving the known product ion spectra from a library, retrieving the sample product ion spectra corresponding to the precursor mass selection window expected to contain a precursor ion corresponding to the known product ion spectra, generating product ion traces in time for the sample product ion spectra for the known product ion spectra, calculating a score for the product ion traces and product ion spectra that represents how well known product ions and sample product ions match, and calculating a quantitative value for the known compound from the product ion traces when the score exceeds a threshold value.Type: GrantFiled: June 17, 2015Date of Patent: May 17, 2016Assignees: DH Technologies Development Pte. Ltd., ETH ZürichInventors: Ronald F. Bonner, Stephen A. Tate, Rudolf Aebersold, Pedro Jose Navarro Alvarez, Oliver Rinner, Lukas Reiter, Ludovic Gillet
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Patent number: 9343279Abstract: Systems and methods are disclosed for identifying detectable compounds of a sample. Sample product ion spectra are received for each mass selection window of precursor mass selection windows for each time step. The received sample product ion spectra are searched for the presence of known compounds of interest with known product ion spectra by retrieving a known product ion spectrum from a library, retrieving the sample product ion spectra corresponding to the precursor mass selection window expected to contain a precursor ion corresponding to the known product ion spectrum, generating product ion traces in time for the retrieved sample product ion spectra, calculating a score for the product ion traces and the retrieved sample product ion spectra that represents how well the retrieved sample product ion spectra and the known product ion spectrum match, and confirming the identity of a precursor ion using the score.Type: GrantFiled: June 17, 2015Date of Patent: May 17, 2016Assignees: DH Technologies Development Pte. Ltd., ETH ZürichInventors: Ronald F. Bonner, Stephen A. Tate, Rudolf Aebersold, Pedro Jose Navarro Alvarez, Oliver Rinner, Lukas Reiter, Ludovic Gillet
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Publication number: 20150287579Abstract: Systems and methods are disclosed for quantitating detectable compounds of a sample. Sample product ion spectra are received for each mass selection window for each time step. The received sample product ion spectra are searched for the presence of known compounds of interest with known product ion spectra by retrieving the known product ion spectra from a library, retrieving the sample product ion spectra corresponding to the precursor mass selection window expected to contain a precursor ion corresponding to the known product ion spectra, generating product ion traces in time for the sample product ion spectra for the known product ion spectra, calculating a score for the product ion traces and product ion spectra that represents how well known product ions and sample product ions match, and calculating a quantitative value for the known compound from the product ion traces when the score exceeds a threshold value.Type: ApplicationFiled: June 17, 2015Publication date: October 8, 2015Inventors: Ronald F. Bonner, Stephen A. Tate, Rudolf Aebersold, Pedro Jose Navarro Alvarez, Oliver Rinner, Lukas Reiter, Ludovic Gillet
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Publication number: 20150279644Abstract: Systems and methods are disclosed for identifying detectable compounds of a sample. Sample product ion spectra are received for each mass selection window of precursor mass selection windows for each time step. The received sample product ion spectra are searched for the presence of known compounds of interest with known product ion spectra by retrieving a known product ion spectrum from a library, retrieving the sample product ion spectra corresponding to the precursor mass selection window expected to contain a precursor ion corresponding to the known product ion spectrum, generating product ion traces in time for the retrieved sample product ion spectra, calculating a score for the product ion traces and the retrieved sample product ion spectra that represents how well the retrieved sample product ion spectra and the known product ion spectrum match, and confirming the identity of a precursor ion using the score.Type: ApplicationFiled: June 17, 2015Publication date: October 1, 2015Inventors: Ronald F. Bonner, Stephen A. Tate, Rudolf Aebersold, Pedro Jose Navarro Alvarez, Oliver Rinner, Lukas Reiter, Ludovic Gillet
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Patent number: 9099288Abstract: Systems and methods are used to store an electronic record of all product ion spectra of all detectable compounds of a sample. A plurality of product ion scans are performed on a tandem mass spectrometer one or more times in a single sample analysis across a mass range using a plurality of mass selection windows. All sample product ion spectra of all detectable compounds for each mass selection window are produced. All sample product ion spectra for each mass selection window are received from the tandem mass spectrometer using a processor. All sample product ion spectra for each mass selection window are stored as an electronic record of all detectable compounds of the sample using the processor. The electronic record is used to characterize compounds known at the time the electronic record is stored or to characterize compounds that became known after the electronic record was stored.Type: GrantFiled: July 11, 2014Date of Patent: August 4, 2015Assignees: DH Technologies Development Pte. Ltd., ETH ZürichInventors: Ronald F. Bonner, Stephen A. Tate, Rudolf Aebersold, Pedro Jose Navarro Alvarez, Oliver Rinner, Lukas Reiter, Ludovic Gillet
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Publication number: 20150144778Abstract: Systems and methods are used to store an electronic record of all product ion spectra of all detectable compounds of a sample. A plurality of product ion scans are performed on a tandem mass spectrometer one or more times in a single sample analysis across a mass range using a plurality of mass selection windows. All sample product ion spectra of all detectable compounds for each mass selection window are produced. All sample product ion spectra for each mass selection window are received from the tandem mass spectrometer using a processor. All sample product ion spectra for each mass selection window are stored as an electronic record of all detectable compounds of the sample using the processor. The electronic record is used to characterize compounds known at the time the electronic record is stored or to characterize compounds that became known after the electronic record was stored.Type: ApplicationFiled: July 11, 2014Publication date: May 28, 2015Inventors: Ronald F. Bonner, Stephen A. Tate, Rudolf Aebersold, Pedro Jose Navarro Alvarez, Oliver Rinner, Lukas Reiter, Ludovic Gillet
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Patent number: 8809770Abstract: Systems and methods are used to store an electronic record of all product ion spectra of all detectable compounds of a sample. A plurality of product ion scans are performed on a tandem mass spectrometer one or more times in a single sample analysis across a mass range using a plurality of mass selection windows. All sample product ion spectra of all detectable compounds for each mass selection window are produced. All sample product ion spectra for each mass selection window are received from the tandem mass spectrometer using a processor. All sample product ion spectra for each mass selection window are stored as an electronic record of all detectable compounds of the sample using the processor. The electronic record is used to characterize compounds known at the time the electronic record is stored or to characterize compounds that became known after the electronic record was stored.Type: GrantFiled: September 14, 2011Date of Patent: August 19, 2014Assignee: DH Technologies Development Pte. Ltd.Inventors: Ronald F. Bonner, Stephen A. Tate, Rudolf Aebersold, Pedro Jose Navarro Alvarez, Oliver Rinner, Lukas Reiter, Ludovic Gillet
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Publication number: 20130206979Abstract: Systems and methods are used to store an electronic record of all product ion spectra of all detectable compounds of a sample. A plurality of product ion scans are performed on a tandem mass spectrometer one or more times in a single sample analysis across a mass range using a plurality of mass selection windows. All sample product ion spectra of all detectable compounds for each mass selection window are produced. All sample product ion spectra for each mass selection window are received from the tandem mass spectrometer using a processor. All sample product ion spectra for each mass selection window are stored as an electronic record of all detectable compounds of the sample using the processor. The electronic record is used to characterize compounds known at the time the electronic record is stored or to characterize compounds that became known after the electronic record was stored.Type: ApplicationFiled: September 14, 2011Publication date: August 15, 2013Inventors: Ronald F. Bonner, Stephen A. Tate, Rudolf Aebersold, Pedro Jose Navarro ALvarez, Oliver Rinner, Lukas Reiter, Ludovic Gillet