Abstract: Provided are methods for determining data defining an estimate of the thickness and density of a cortical bone tissue structure of interest from imaging data. The methods can include modelling measured variations of an imaging parameter along a line crossing a cortical bone tissue structure of interest as a function having a thickness parameter, a first density parameter, and a blur parameter; determining a thickness-density relationship between bone tissue structure density and bone tissue structure thickness from multiple thickness and density measurements made on a reference cortical bone tissue structure of a subject which is not the patient; and fitting the function to the measured variations while ensuring the first density parameter and thickness parameter follow the thickness-density relationship, to search for optimal values that include data defining an estimate of the thickness and density of the cortical bone tissue structure of interest.

Abstract: Provided are methods for determining data defining an estimate of the thickness and density of a cortical bone tissue structure of interest from imaging data. The methods can include modelling measured variations of an imaging parameter along a line crossing a cortical bone tissue structure of interest as a function having a thickness parameter, a first density parameter, and a blur parameter; determining a thickness-density relationship between bone tissue structure density and bone tissue structure thickness from multiple thickness and density measurements made on a reference cortical bone tissue structure of a subject which is not the patient; and fitting the function to the measured variations while ensuring the first density parameter and thickness parameter follow the thickness-density relationship, to search for optimal values that include data defining an estimate of the thickness and density of the cortical bone tissue structure of interest.

Abstract: Method for reconstruction of a three-dimensional model of a body structure of a subject, said structure comprising a plurality of objects, wherein a database (21) of the structure is provided, the database comprising means to estimate, from a parameter of any object of the structure, another parameter for an object of the structure, a preliminary solution for a first object (L1) is modified to be brought in concordance with subject-specific data (23a, 23b), a reconstruction of the second object (T12) is obtained based on the modified first object and on the database of structure (21).

Abstract: Method for reconstruction of a three-dimensional model of a body structure of a subject, said structure comprising a plurality of objects, wherein a database (21) of the structure is provided, the database comprising means to estimate, from a parameter of any object of the structure, another parameter for an object of the structure, a preliminary solution for a first object (L1) is modified to be brought in concordance with subject-specific data (23a, 23b), a reconstruction of the second object (T12) is obtained based on the modified first object and on the database of structure (21).