Patents by Inventor Ludovic Rodriguez
Ludovic Rodriguez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4525358Abstract: New 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids, their amides and their salts, processes for the preparation thereof and therapeutic compositions. These compounds have the formula ##STR1## wherein Y=--OH or --NH.sub.2 ; X and X'=H, halogen, alkoxy or trifluoromethyl; m=1 or 2 and n=1 or 2.The amides of the 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids are prepared either by reacting a 1-(diphenylmethyl)-piperazine with an omegahaloacetamide, or by reacting an alkali metal salt of an omega-[4-(diphenylmethyl)-1-piperazinyl]-alkanol with a 2-haloacetamide, or yet by reacting ammonia with a halide or alkyl ester of a 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acid, whereas the 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids are prepared by hydrolyzing the corresponding amide or lower alkyl ester.These compounds have in particular an antiallergic, spasmolytic and antihistaminic activity.Type: GrantFiled: May 17, 1983Date of Patent: June 25, 1985Assignee: UCB Pharmaceuticals, Inc.Inventors: Eugene Baltes, Jean de Lannoy, Ludovic Rodriguez
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Patent number: 4443460Abstract: New 2-[4-(diphenylmethylene)-1-piperidinyl]-acetic acids and their amides, processes for the preparation thereof and therapeutic compositions. These compounds have the formula ##STR1## wherein Y=--OH or --NR.sub.1 R.sub.2, R.sub.1 and R.sub.2 =H, alkyl or phenyl; X=H, halogen or alkoxy; m=0, 1 or 2 and n=1 or 2.The 2-[4-(diphenylmethylene)-1-piperidinyl]-acetic acids are prepared by hydrolyzing the corresponding amide or lower alkyl ester, whereas the amides are prepared either by reacting a 4-(diphenylmethylene)-piperidine with an omega-haloacetamide, or by reacting an alkali metal salt of an omega-[4-diphenylmethylene)-1-piperidinyl]-alkanol (m=1 or 2) with a 2-haloacetamide, or by reacting a nitrogen compound (HNR.sub.1 R.sub.2) with a halide or alkyl ester of a 2-[4-(diphenylmethylene)-1-piperidinyl]-acetic acid.These compounds have in particular an antiallergic, spasmolytic, antihistaminic and broncholytic activity.Type: GrantFiled: September 17, 1981Date of Patent: April 17, 1984Assignee: UCB, Societe AnonymeInventors: Ludovic Rodriguez, Eugene Baltes
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Patent number: 4271173Abstract: 6-Amino-spiro[penam-2,4'-piperidine]-3-carboxylic acid derivatives having the formula ##STR1## wherein R is a methyl, phenyl or benzyl radical, Z.sub.1 is a hydrogen atom and Z.sub.2 is a radical selected from those known from penicillin chemistry and is preferably a 2-phenylacetyl, 2-amino-2-phenylacetyl, 5-methyl-3-phenyl-4-isoxazolecarbonyl or 2,6-dimethoxybenzoyl radical, or Z.sub.1 and Z.sub.2 together represent a bivalent radical Z.sub.3 and preferably a (hexahydro-1H-azepin-1-yl)methylene radical, as well as the pharmaceutically acceptable non-toxic salts thereof and process for preparing the same.These compounds have valuable antibacterial properties and are useful as therapeutic agents in the treatment of infectious diseases caused by Gram-positive and Gram-negative bacteria.Type: GrantFiled: June 24, 1980Date of Patent: June 2, 1981Assignee: U C B, Societe AnonymeInventors: Ludovic Rodriguez, Jacques Leclercq, Pierre Ykman, Eric Cossement
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Patent number: 4271172Abstract: 6-Amino-spiro[penam-2,4'-piperidine]-3-carboxylic acids, salts and esters thereof of the formula ##STR1## wherein R.sub.1 is hydrogen, benzyl or an alkali metal or ammonium ion and R.sub.2 is methyl, phenyl or benzyl and process for preparing the same.These compounds are useful as intermediates in the synthesis of a new group of antibiotics having properties similar to penicillins, besides own antibiotic activity with a broad antibacterial spectrum. Therefore, they are useful as antibacterials agents and as therapeutic agents for humans and for animals in the treatment of infectious diseases caused by Gram-positive and Gram-negative bacteria.Type: GrantFiled: June 24, 1980Date of Patent: June 2, 1981Assignee: U C B Societe AnonymeInventors: Ludovic Rodriguez, Jacques Leclercq, Pierre Ykman, Eric Cossement
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Patent number: 4221789Abstract: New lactam-N-acetic acids and amides thereof having the formula ##STR1## wherein R.sub.1 and R.sub.2 =H, C.sub.1 -C.sub.4 -alkyl, aryl or halogen-substituted aryl,R.sub.3 =OH or --NR.sub.4 R.sub.5,R.sub.4 and R.sub.5 =H, C.sub.1 -C.sub.4 -alkyl, cycloalkyl, aralkyl or, taken together with the N atom form alkyleneimino, oxa-alkyleneimino, aza-alkyleneimino or N-benzyl-aza-alkyleneimino,m is 3, 4 or 5, preferably 3,n is 0, 1 or 2, preferably 2;and the pharmaceutically acceptable salts of said acids. Processes for producing these compounds and pharmaceutical compositions containing the same are also given. These compounds show amongst others beneficial activity on the mnemic processes and cardiac activity.Type: GrantFiled: May 7, 1979Date of Patent: September 9, 1980Assignee: UCB, Societe AnonymeInventors: Ludovic Rodriguez, Lucien Marchal
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Patent number: 4162325Abstract: New physiologically active N-substituted lactams having the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7, represent independently a hydrogen atom, an alkyl radical containing 1 to 4 carbon atoms or a phenyl group, R.sub.8 is a hydrogen atom or R.sub.8 and R.sub.3 together form the ethylene or trimethylene radical, and n is 3, 4 or 5, processes for the preparation thereof and pharmaceutical compositions containing the same.Type: GrantFiled: October 19, 1977Date of Patent: July 24, 1979Assignee: UCB, Societe AnonymeInventors: Ludovic Rodriguez, Lucien Marchal
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Patent number: 4145343Abstract: 6'-Amino-spiro?cycloalkane-1,2'-penam!-3'-carboxylic acid derivatives having the formula ##STR1## WHEREIN N IS A WHOLE NUMBER OF FROM 3 TO 6 AND R.sub.1 and R.sub.2 represent substituents known in the chemistry of penicillins, and their pharmaceutically acceptable, non-toxic salts, have valuable antibacterial properties and are useful as therapeutic agents in the treatment of infectious diseases caused by Gram-positive and Gram-negative bacteria. Processes for preparing these compounds are also described.Type: GrantFiled: May 24, 1977Date of Patent: March 20, 1979Assignee: UCB Societe AnonymeInventors: Ludovic Rodriguez, Jacques Leclercq
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Patent number: 4139628Abstract: Amino-spiro[oxa(or thia)cycloalkane-penam]-carboxylic acid derivatives having the formula ##STR1## WHEREIN X is a sulfur or oxygen atom or the sulfinyl group, n is 1 or 2, m is 1 or 2, R.sub.1 is hydrogen, R.sub.2 is one of the radicals known in the chemistry of the penicillins, preferably 2-phenylacetyl, 2-amino-2-phenylacetyl, 5-methyl-3-phenyl-4-isoxazolecarbonyl or 2,6-dimethoxybenzoyl, or R.sub.1 and R.sub.2 together represent a bivalent radical R.sub.3, preferably (hexahydro-1H-azepin-1-yl)methylene and their therapeutically acceptable non-toxic salts and process for preparing the same.These compounds have valuable antibacterial properties and are useful as therapeutic agents in the treatment of infectious diseases caused by Gram-positive and Gram-negative bacteria.Type: GrantFiled: January 16, 1978Date of Patent: February 13, 1979Assignee: U C B, Societe AnonymeInventors: Ludovic Rodriguez, Jacques Leclercq, Pierre Ykman, Eric Cossement
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Patent number: 4137236Abstract: Amino-spiro[oxa(or thia)cycloalkane-penam]-carboxylic acid, a salt or an ester thereof, of the formula ##STR1## wherein Z is a hydrogen or an alkali metal atom, or a group protecting the carboxylic function, X is a sulfur or oxygen atom, n is 1 or 2, m is 1 or 2, and process of preparing the same.These compounds are useful as intermediates in the synthesis of a new group of antibiotics having properties similar to penicillins, besides own antibiotic activity with a broad antibacterial spectrum.Type: GrantFiled: January 16, 1978Date of Patent: January 30, 1979Assignee: U C B, Societe AnonymeInventors: Ludovic Rodriguez, Jacques Leclerca, Pierre Ykman, Eric Cossement
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Patent number: 4091027Abstract: 6'-Amino-spiro[cycloalkane-1,2'-penam]-3'-carboxylic acids of the formula ##STR1## WHEREIN Z is a hydrogen or an alkali metal atom, or a protective group, and n a whole number of from 3 to 6, and process of preparing the same.These compounds are useful as intermediates in the synthesis of a new group of antibiotics having properties similar to the penicillins.Type: GrantFiled: May 24, 1977Date of Patent: May 23, 1978Assignee: U C B Societe AnonymeInventors: Ludovic Rodriguez, Jacques Leclercq
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Patent number: 4080450Abstract: New physiologically active 2-carbamoyl-1,2,4,5-tetrahydro-3H-2-benzazepin-3-ones having the general formula ##STR1## wherein R.sub.1 is hydrogen or phenyl, R.sub.2 is morpholino or amino mono- or di-substituted by C.sub.1 -C.sub.4 -alkyl, C.sub.5 -C.sub.6 -cycloalkyl or phenyl, R.sub.4 is hydrogen or C.sub.1 -C.sub.4 -alkyl, R.sub.5 is hydrogen or C.sub.1 -C.sub.4 -alkyl, R.sub.7 is hydrogen, halogen or C.sub.1 -C.sub.4 -alkoxy, R.sub.8 is hydrogen, halogen or C.sub.1 -C.sub.4 -alkyl, processes for the preparation thereof and pharmaceutical compositions containing the same. In particular, the compounds of this invention are useful in the treatment of memory disorders.Type: GrantFiled: July 27, 1977Date of Patent: March 21, 1978Assignee: U C B, Societe AnonymeInventors: Paul Croisier, Ludovic Rodriguez