Abstract: Disclosed is a device including a skin microscope for acquiring images at different wavelengths of one or more areas of a person's skin. The device includes one or more pH sensors, one or more temperature sensors, a bioimpedance sensor and a pulse oximeter included in the device so that, together with the acquisition of a skin image, it is possible to co-register the temperature, the bioimpedance and saturation of hemoglobin in the field of view of the microscope, and the pH in the immediate vicinity of that field of view. The device can be connected to an electronic device, such as a “smartphone”, for the transmission of the acquired data to the latter, possibly after they have undergone initial processing using specific algorithms.

Abstract: A computer system and method for sequencing deoxyribonucleic acid (DNA), to determine the order of the different nucleotides in a genomic sequence or sequence fragment. An alignment system employs a direct “brute force” Hamming distance calculation between a read sequence and a reference genome. The alignment system is configured to compare directly a set of DNA fragments to a reference genome in a short period, and with the higher probability of accuracy than similar comparison systems given the same number of clock cycles. Each DNA fragment is compared with a reference genome for the entire length of the latter using arrangements of memory cells for storing read sequences and inverse complements of the read sequences, shift registers for streaming the reference genome, and circuitry for calculating and summing the distance between the reference, the read sequence, and the inverse complement in parallel. Both digital and analog implementations are described.

Abstract: A computer system and method for sequencing deoxyribonucleic acid (DNA), to determine the order of the different nucleotides in a genomic sequence or sequence fragment. An alignment system employs a direct “brute force” Hamming distance calculation between a read sequence and a reference genome. The alignment system is configured to compare directly a set of DNA fragments to a reference genome in a short period, and with the higher probability of accuracy than similar comparison systems given the same number of clock cycles. Each DNA fragment is compared with a reference genome for the entire length of the latter using arrangements of memory cells for storing read sequences and inverse complements of the read sequences, shift registers for streaming the reference genome, and circuitry for calculating and summing the distance between the reference, the read sequence, and the inverse complement in parallel. Both digital and analog implementations are described.