Abstract: This invention relates to a semisolid ophthalmic composition, in particular an ointment, comprising (1) an ophthalmic drug, e.g. a staurosporine derivative, (2) an ointment base and (3) an agent for dispersing and/or dissolving said drug in the ointment base, selected from a poly(ethylene-glycol), a polyethoxylated castor oil, an alcohol having 12 to 20 carbon atoms and a mixture of two or more of said components.

Abstract: Use of a compound of formula (I): wherein the symbol cyclodextrin? ]n represents a n-valent residue derived from a cyclodextrin compound by removing n of its hydroxyl groups; n is a number greater than 0 and represents the average number of substituents of formula per molecule of said compound; h is 0 or 1; R1 is a di-valent group selected from alkylene, hydroxy alkylene, halogeno alkylene, monocyclic aralkylene, cycloalkylene and phenylene; R2, R3 and R4 are each independently of one another a group selected from alkyl, cycloalkyl, aryl, aralkyl, and cycloheteryl; Xm? is a m-fold negatively charged anion; m is an integer being equal or greater than 1; and k is n/m in the preparation of an anti-infective medicament, as preservative and penetration enhancer.

Abstract: The present invention describes in particular a method for stabilizing a pharmaceutical composition by contacting said composition with a polymeric material comprising in particular an ethylene oxide sterilization step.

Abstract: The present invention relates to a pharmaceutical composition comprising a peranhydrocyclodextrin, a drug and a carrier, to the use of a peranhydrocyclodextrin as a drug transport enhancer (e.g. permeation enhancer), and to the use of a peranhydrocyclodextrin in the preparation of a pharmaceutical composition as a synergistic adjunctive system.

Abstract: Use of a compound of formula (I): wherein the symbol represents a n-valent residue derived from a cyclodextrin compound by removing n of its hydroxyl groups; n is a number greater than 0 and represents the average number of substituents of formula per molecule of said compound; h is 0 or 1; R1 is a di-valent group selected from alkylene, hydroxy alkylene, halogeno alkylene, monocyclic aralkylene, cycloalkylene and phenylene; R2, R3 and R4 are each independently of one another a group selected from alkyl, cycloalkyl, aryl, aralkyl, and cycloheteryl; xm? is a m-fold negatively charged anion; m is an integer being equal or greater than 1; and k is n/m in the preparation of an anti-infective medicament, as preservative and penetration enhancer.

Abstract: The present invention describes in particular a method for stabilizing a pharmaceutical composition by contacting said composition with a polymeric material comprising in particular an ethylene oxide sterilization step.

Abstract: The present invention relates to a pharmaceutical composition comprising a peranhydrocyclodextrin, a drug and a carrier, to the use of a peranhydrocyclodextrin as a drug transport enhancer (e.g. permeation enhancer), and to the use of a peranhydrocyclodextrin in the preparation of a pharmaceutical composition as a synergistic adjunctive system.

Abstract: The present invention relates to a method of protecting copper-sensitive compounds and/or compositions from decomposition.

Abstract: The present invention describes in particular a method for stabilizing a pharmaceutical composition by contacting said composition with a polymeric material comprising in particular an ethylene oxide sterilization step.

Abstract: The testing head of an apparatus for determining the permeability of a web to air comprises two rotatable parallel contact rollers, which are mounted between two end walls and comprise a rubber-elastic sheath each, and two sealing belts, which are trained around said contact rollers at both ends thereof and adjacent to their outer edges are provided with a sealing lip, which contacts the adjacent end wall. An endless covering belt is trained around reversing pulleys so that a suction space which is provided between the contact rollers and serves to suck a stream of measuring air through the web is closed at the top.

Abstract: An apparatus for needling a nonwoven web comprises a needle carrier, which is adapted to be driven, and a bedplate and a stripper for guiding the web between them. In order to impart a pure rotary motion to the needle carrier, the needle carrier consists of a roller and is adapted to rotate about its own axis and to revolve in the opposite sense about an axis of revolution which is parallel to the axis of the roller so that each needle describes a hypocycloidal path.

Abstract: An endless fibrous web is to be needled from both sides by needling means for piercing the web in only one direction. For that purpose the web is needled in the form of a twisted endless web, which is known as a Mobius web and has been formed in that the two ends of a finite length of the web have been rotated through 180.degree. relative to each other about the longitudinal axis of the web and have then been joined.