Patents by Inventor Ludwig Labler

Ludwig Labler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of cholesterol derivatives and novel intermediates therefor
    Patent number: 4691032
    Abstract: The invention is concerned with a process for the preparation of 1 hydrogen or hydroxy cholesterol derivatives and intermediates therefor. The compounds of the present invention are useful as intermediates in the preparation of 24,25-dihydroxy and 1.alpha.,24,25-trihydroxycholecalciferol.
    Type: Grant
    Filed: November 1, 1985
    Date of Patent: September 1, 1987
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andor Furst, Ludwig Labler, Werner Meier
  • Process for the preparation of cholesterol derivatives and novel intermediates therefor
    Patent number: 4568491
    Abstract: The invention is concerned with a process for the preparation of 1 hydrogen or hydroxy cholesterol derivatives and intermediates therefor. The compounds of the present invention are useful as intermediates in the preparation of 24,25-dihydroxy and 1.alpha., 24,25-trihydroxycholecalciferol.
    Type: Grant
    Filed: February 27, 1984
    Date of Patent: February 4, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andor Furst, Ludwig Labler, Werner Meier
  • Process for the manufacture of cholesterol derivatives
    Patent number: 4312812
    Abstract: The present disclosure is directed to a process for the preparation of cholesterol derivatives from corresponding 21-hydroxymethyl steroidal compounds.
    Type: Grant
    Filed: January 19, 1981
    Date of Patent: January 26, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andor Furst, Ludwig Labler, Werner Meier
  • Process for 1.alpha.,3.beta.-dihydroxy-.DELTA..sup.5 -steroids
    Patent number: 4305881
    Abstract: A process for the synthesis of 1.alpha.,3.beta.-dihydroxy-.DELTA..sup.5 -steroids from steroids such as 1.alpha.,2.alpha.-epoxy-cholesta-4,6-dien-3-one, which is reacted with lithium in liquid ammonia in the absence of a proton donator and subsequently reduced by repeated alternative additions of a proton donator, said additions being followed in each case by an equivalent amount of lithium. The final product, a 1.alpha.,3.beta.-dihydorxy-.DELTA..sup.5 -steroid, is useful in the synthesis of derivatives of cholecalciferol.
    Type: Grant
    Filed: November 13, 1979
    Date of Patent: December 15, 1981
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andor Furst, Ludwig Labler, Werner Meier
  • Pregnane derivatives
    Patent number: 4193921
    Abstract: The present invention relates to pregnane derivatives of the formula ##STR1## wherein R.sup.1 and R.sup.3 are hydroxyl groups or readily cleavable etherified or esterified hydroxyl groups and R.sup.20 is hydroxymethyl or readily cleavable etherified or esterified hydroxy methyl, formyl, carboxyl or carbalkoxy useful as intermediates for the preparation of 1.alpha.-hydroxycholecalciferols. The present invention also relates to processes for the preparation of the pregnane derivatives and the intermediates thereof.
    Type: Grant
    Filed: October 12, 1977
    Date of Patent: March 18, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andor Furst, Ludwig Labler, Werner Meier
  • Methylation of de-A steroids
    Patent number: 4087436
    Abstract: Treatment of de-A steroids with a methylation agent at extremely low temperatures, i.e., below -50.degree. C. produces corresponding 10.beta.-methyl-.DELTA..sup.9(11) -deA steroids with a high 10.beta. to 10.alpha. isomer ratio. A number of the product 10.beta.-methyl-.DELTA..sup.9(11) -deA steroids are novel compounds. They are useful as intermediates in the synthesis of known medicinally valuable steroids.
    Type: Grant
    Filed: June 23, 1975
    Date of Patent: May 2, 1978
    Assignee: Hoffmann-La Roche, Inc.
    Inventors: Paul Buchschacher, Andor Furst, Ludwig Labler, Werner Meier, John William Scott