Patents by Inventor Ludwig Thierfelder

Ludwig Thierfelder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for detecting mutations associated with hypertrophic cardiomyopathy
    Publication number: 20040086876
    Abstract: The invention pertains to methods for detecting the presence or absence of a mutation associated with hypertrophic cardiomyopathy (HC). The methods include providing DNA which encodes a cardiac myosin binding protein and detecting the presence or absence of a mutation in the amplified product which is associated with HC. The invention further pertains to methods for diagnosing HC in a subject. These methods typically include obtaining a sample of DNA which encodes a cardiac myosin binding protein from a subject being tested for FHC and diagnosing the subject for FHC by detecting the presence or absence of a mutation in the sarcomeric thin filament protein which causes FHC as an indication of the disease. Other aspects of the invention include kits useful for diagnosing HC and methods for treating HC.
    Type: Application
    Filed: November 4, 2002
    Publication date: May 6, 2004
    Applicants: President and Fellows of Harvard College, Brigham and Women's Hospital
    Inventors: Christine Seidman, Jonathan Seidman, Ludwig Thierfelder, Hugh Watkins, Calum McRae
  • METHODS FOR DETECTING MUTATIONS ASSOCIATED WITH HYPERTROPHIC CARDIOMYOPATHY
    Publication number: 20020127548
    Abstract: The invention pertains to methods for detecting the presence or absence of a mutation associated with hypertrophic cardiomyopathy (HC). The methods include providing DNA which encodes a cardiac myosin binding protein and detecting the presence or absence of a mutation in the amplified product which is associated with HC. The invention further pertains to methods for diagnosing HC in a subject. These methods typically include obtaining a sample of DNA which encodes a cardiac myosin binding protein from a subject being tested for FHC and diagnosing the subject for FHC by detecting the presence or absence of a mutation in the sarcomeric thin filament protein which causes FHC as an indication of the disease. Other aspects of the invention include kits useful for diagnosing HC and methods for treating HC.
    Type: Application
    Filed: November 30, 1995
    Publication date: September 12, 2002
    Inventors: CHRISTINE SIEDMAN, JONATHAN SEIDMAN, LUDWIG THIERFELDER, HUGH WATKINS, CALUM MCRAE
  • Methods for detecting mutations associated with hypertrophic cardiomyopathy
    Patent number: 5912121
    Abstract: The invention pertains to methods for detecting the presence or absence of a mutation associated with hypertrophic cardiomyopathy (HC). The methods include providing DNA which encodes a sarcomeric thin filament protein (e.g., .alpha.-tropomyosin or cardiac troponin T) and detecting the presence or absence of a mutation in the amplified product which is associated with HC. DNA encoding an actin-associated protein, a myosin-associated protein, or a sarcomeric protein other than .beta. cardiac heavy chain can also be used in the methods of the present invention. The invention further pertains to methods for diagnosing familial HC (FHC) in a subject. These methods typically include obtaining a sample of DNA which encodes a sarcomeric thin filament protein from a subject being tested for FHC and diagnosing the subject for FHC by detecting the presence or absence of a mutation in the sarcomeric thin filament protein which causes FHC as an indication of the disease.
    Type: Grant
    Filed: December 12, 1994
    Date of Patent: June 15, 1999
    Assignees: Bringham and Women's Hospital, President and Fellows of Harvard College
    Inventors: Christine Seidman, Jonathan Seidman, Ludwig Thierfelder, Hugh Watkins, Calum McRae
  • Methods for detecting mutations associated with hypertrophic cardiomyopathy
    Patent number: 5840477
    Abstract: The invention pertains to methods for detecting the presence or absence of a mutation associated with hypertrophic cardiomyopathy (HC). The methods include providing DNA which encodes a sarcomeric thin filament protein (e.g., .alpha.-tropomyosin or cardiac troponin T) and detecting the presence or absence of a mutation in the amplified product which is associated with HC. DNA encoding an actin-associated protein, a myosin-associated protein, or a sarcomeric protein other than .beta. cardiac heavy chain can also be used in the methods of the present invention. The invention further pertains to methods for diagnosing familial HC (FHC) in a subject. These methods typically include obtaining a sample of DNA which encodes a sarcomeric thin filament protein from a subject being tested for FHC and diagnosing the subject for FHC by detecting the presence or absence of a mutation in the sarcomeric thin filament protein which causes FHC as an indication of the disease.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 24, 1998
    Assignees: Brigham & Women's Hospital, President & Fellows of Harvard College
    Inventors: Christine Seidman, Jonathan Seidman, Ludwig Thierfelder, Hugh Watkins, Calum McRae