Abstract: Flask which is fitted with a closure which can be sealed in such a manner as to ensure sterility of its contents and which is characterized in that it is provided at its head part with a thread, preferably a round thread which is connected with a conical ring, and in that the corresponding closure cap has an inner thread so formed as to correspond on the flask, and in which the open end of the closing cap is provided with a recess into which the tamper-proof ring is pressed in.

Abstract: A process for the preparation of a container closed under sterile conditions and containing lyophilized material, which comprises1. filling the material to be lyophilized into a container,2. putting a rubber stopper and a closing cap loosely on the container,3. introducing the container with its contents into a lyophilization apparatus,4. lyophilizing the contents,5. within the lyophilization apparatus and in a single operation, pressing the rubber stopper deep into the container, at the same time pressing the closing cap onto the same, and6. removing the container closed under sterile conditions from the lyophilization apparatus.

Abstract: The subject matter of the invention is a closable sterile container and the associated closure cap, which can simultaneously be used as a pipette and which is a tamper-proof closure in conjunction with the container.