Patents by Inventor Lufeng YAN

Lufeng YAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mixture of fucosylated chondroitin sulfate oligosaccharides and method for rapidly producing the same
    Patent number: 11202797
    Abstract: The present invention discloses a mixture of fucosylated chondroitin sulfate oligosaccharides having an average molecular weight between 2700 Da and 3600 Da, in which 90% of total components has a molecular weight between 1800 Da and 5400 Da. The mixture of fucosylated chondroitin sulfate oligosaccharide of the present invention has very low anti-FIIa factor activity, very low anti-FXa factor activity, very high anti-FXase factor activity, i.e., having a significant activity in selectively inhibiting intrinsic FXase, and a significant antithrombotic activity and no risk of bleeding and hypotension that are proved through animal experiments. The present invention also discloses a method for rapidly producing fucosylated chondroitin sulfate oligosaccharides by using sea cucumber as raw material, and the method includes: intercepting and concentrating crude polysaccharide with a membrane, deacetylation with hydrazine, pyrolysis with nitrous acid, reduction with sodium borohydride, membrane separation, etc.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: December 21, 2021
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Shiguo Chen, Lufeng Yan, Danli Wang, Junhui Li, Xingqian Ye, Donghong Liu
  • FUCOSYLATED CHONDROITIN SULFATE OLIGOSACCHARIDE AND METHOD FOR RAPIDLY PRODUCING THE SAME
    Publication number: 20200261493
    Abstract: The present invention discloses a mixture of fucosylated chondroitin sulfate oligosaccharides having an average molecular weight between 2700 Da and 3600 Da, in which 90% of total components has a molecular weight between 1800 Da and 5400 Da. The mixture of fucosylated chondroitin sulfate oligosaccharide of the present invention has very low anti-FIIa factor activity, very low anti-FXa factor activity, very high anti-FXase factor activity, i.e., having a significant activity in selectively inhibiting intrinsic FXase, and a significant antithrombotic activity and no risk of bleeding and hypotension that are proved through animal experiments. The present invention also discloses a method for rapidly producing fucosylated chondroitin sulfate oligosaccharides by using sea cucumber as raw material, and the method includes: intercepting and concentrating crude polysaccharide with a membrane, deacetylation with hydrazine, pyrolysis with nitrous acid, reduction with sodium borohydride, membrane separation, etc.
    Type: Application
    Filed: July 11, 2018
    Publication date: August 20, 2020
    Inventors: Shiguo CHEN, Lufeng YAN, Danli WANG, Junhui LI, Xingqian YE, Donghong LIU