Abstract: Provided are compounds of the Formula (I), or their pharmaceutically acceptable salts, can inhibit TNFR1 and are expected to have utility as therapeutic agents, for example, for treating inflammatory bowel diseases, rheumatoid arthritis, junvenile rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis, non-radiographic axial spondyloarthritis and hidradenitis suppurativa. The disclosure also provides pharmaceutical compositions which comprise the compounds disclosed herein or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of inflammatory bowel diseases, rheumatoid arthritis, juvenile rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis, non-radiographic axial spondyloarthritis and hidradenitis suppurativa, and for preparing pharmaceuticals for this purpose.

Abstract: The invention relates to a nebulization device (1) for medical mixture. It comprises a containing ampoule (2) for medical mixture, comprising an upper component (2a) and a lower component (2b) connected to each other, at least one emission opening (11) of the nebulized medical mixture from the ampoule (2), and at least one entry window (19) for the intake of air within the ampoule (2). Moreover, the nebulization device (1) comprises at least one atomizer (14) for the intake of pressurized gas, within the lower component (2b) of the ampoule (2), the atomizer (14) being surmounted by the upper component (2a). Advantageously, at least one, preferably two selection side windows (24) are provided on the upper component (2a), the opening of the selection side windows (24) being shielded by shielding means (16), moved by a command shaft (17).

Abstract: The invention relates to a nebulization device (1) for medical mixture, of the type comprising: a containing ampoule (2) for medical mixture, comprising an upper component (2a) and a lower component (2b) connected to each other; at least one emission opening (11) of said nebulized medical mixture from the ampoule (2), and at least one entry window (19) for the intake of air within said ampoule (2); as well as at least one atomizer (14) for the intake of pressurized gas, within the lower component (2b) of the ampoule (2), the atomizer (14) being surmounted by the upper component (2a). Advantageously, at least one, preferably two selection side windows (24) are provided on the upper component (2a), the opening of said selection side windows (24) being shielded by shielding means (16), moved by a command shaft (17).

Abstract: Portable nebulizer apparatus for medical use, comprising a mesh arranged so as to intercept an internal fluid path which leads into a dispenser outlet, and an oscillator element which causes said mesh to oscillate, the mesh being integrated in an extractable mesh assembly housed between a first and a second half-casing, the half-casings being movable in relation to each other between a coupled operational configuration and a separated configuration which allows access to the mesh assembly.

Abstract: Mesh (1) for nebulizer apparatus for medical applications, with a structure which is particularly rigid and easy to fix in position inside the nebulizer apparatus, comprising a vibratile foil (10) crossed by a plurality of nebulizing holes (11) and a peripheral embossed edge (12) integral with the vibratile foil (10).

Abstract: The invention concerns a device for washing nasal cavities by a nebulized liquid, that comprises a main body (12), a tank for liquids (14) including at least a nebulization chamber (23), and means of collection and nebulization of the treatment liquid from said nebulization chamber and delivery of the nebulized liquid towards the nasal cavities with the help of a flow of air under pressure generated by a compressor group. The main body (12) has a cavity and the compressor group (18), a piloting electronic circuit (20) and an electric battery system (31) are all on board of a single support housed and retained in the cavity of said main body.

Abstract: This invention concerns an ampoule nebulizer per aerosol therapy at different medicament delivery speeds. It comprises a body with a through conduit (30) for the delivery of ambient air from outside. The though conduit is associated with a selection push-button (31) which moves between a first blocking or partially blocking position of the entry of said conduit for the choice of a first low feed speed and at least a second opening position of the entry of said conduit in order to choose a second higher medicament feed speed. Said positions are defined by stop means (35, 36) and between one and the other, one or more additional intermediate positions can be provided. Furthermore, the selection push-button can be associated with an additional valve (132) in order to vary the flow of ambient air from outside during functioning at low speed.

Abstract: The invention concerns an apparatus for creating a vacuum in containers, both flexible like bags, and rigid, for the preservation of vacuum packaged products. It comprises a base plate (11) having a front part separable and behind the suction chamber (15), a notch (21) designed to house a roll (22) of a tubular element extractable from the front of the apparatus and cut using a trimmer (23) placed on board a casing or cover(12) above the base plate.

Abstract: The invention concerns an operating unit to generate a flow of air under pressure in aerosol therapy equipment, comprising a pump group (12) powered by a motor and having a head (19), with an air inlet duct (22) complete with filter (24) and an air outlet duct (23). The pump group is enclosed in a body made up of two shells, top and bottom, (13, 14) which overlap and fit together on a transversal plane at the level of their edges. The shells forming the body receive and hold the air inlet duct (22) with filter, the air outlet duct (23) and a plate with socket and switch following their overlapping for automizable assembly of the group.

Abstract: The invention concerns a device for washing nasal cavities by a nebulized liquid, that comprises a main body (12), a tank for liquids (14) including at least a nebulization chamber (23), and means of collection and nebulization of the treatment liquid from said nebulization chamber and delivery of the nebulized liquid towards the nasal cavities with the help of a flow of air under pressure generated by a compressor group. The main body (12) has a cavity and the compressor group (18), a piloting electronic circuit (20) and an electric battery system (31) are all on board of a single support housed and retained in the cavity of said main body.

Abstract: The invention concerns an operating unit to generate a flow of air under pressure in aerosol therapy equipment, comprising a pump group (12) powered by a motor and having a head (19), with an air inlet duct (22) complete with filter (24) and an air outlet duct (23). The pump group is enclosed in a body made up of two shells, top and bottom, (13, 14) which overlap and fit together on a transversal plane at the level of their edges. The shells forming the body have means for receiving and holding the air inlet duct (22) with filter, the air outlet duct (23) and a plate with socket and switch following their overlapping for automizable assembly of the group.

Abstract: The invention concerns a method of forming a film for the construction of bags for vacuum packing of products which comprises: depositing an additional resin film on the internal face of an initial film, running the initial film complete with the added film between a smooth feed roller and a shaping roller having a multiplicity of alternating peripheral impressions and ridges, and bringing the additional film in close contact with the shaping roller so as to have portions of additional resin flow into the impressions of the shaping roller to form the ridges defining the ducts. The invention also concerns the film realised with the method and the bags constructed using such film.