Patents by Inventor Luigi Agrofoglio

Luigi Agrofoglio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antiviral acyclonucleoside analogues for use in treating a viral infection
    Patent number: 11603380
    Abstract: The present invention concerns a compound having the following formula (I): as well as its use as a medicament, especially for its use for treating viral infections.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: March 14, 2023
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'ORLEANS, NEOVIRTECH
    Inventors: Luigi Agrofoglio, Vincent Roy, Coralie De Schutter, Maxime Bessieres, Franck Gallardo
  • Benzimidazol derivatives for treating filovirus infection
    Patent number: 11479571
    Abstract: The present invention relates to compounds comprising a benzimidazole scaffold, and the use of such compounds for the treatment of viral diseases. The invention also relates to pharmaceutical compositions comprising said compounds as an active ingredient. In particular the compounds of the invention comprising a benzimidazole scaffold are used for the treatment of filoviruses or retroviruses, and preferably for the treatment of Ebola virus or HIV virus.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: October 25, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'ORLEANS
    Inventors: Luigi Agrofoglio, Vincent Roy, Elzbieta Plebanek, Maxime Bessieres
  • BENZIMIDAZOL DERIVATIVES FOR TREATING FILOVIRUS INFECTION
    Publication number: 20210292350
    Abstract: The present invention relates to compounds comprising a benzimidazole scaffold, and the use of such compounds for the treatment of viral diseases. The invention also relates to pharmaceutical compositions comprising said compounds as an active ingredient. In particular the compounds of the invention comprising a benzimidazole scaffold are used for the treatment of filoviruses or retroviruses, and preferably for the treatment of Ebola virus or HIV virus.
    Type: Application
    Filed: September 14, 2017
    Publication date: September 23, 2021
    Inventors: Luigi AGROFOGLIO, Vincent ROY, Elzbieta PLEBANEK, Maxime BESSIERES
  • NEW ANTIVIRAL ACYCLONUCLEOSIDE ANALOGUES
    Publication number: 20210079031
    Abstract: The present invention concerns a compound having the following formula (I): as well as its use as a medicament, especially for its use for treating viral infections.
    Type: Application
    Filed: April 23, 2019
    Publication date: March 18, 2021
    Inventors: Luigi AGROFOGLIO, Vincent ROY, Coralie DE SCHUTTER, Maxime BESSIERES, Franck GALLARDO
  • Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability
    Patent number: 8785629
    Abstract: Synthons for the synthesis of phosphonates prodrugs POM and POC, especially for direct Cross Metathesis.
    Type: Grant
    Filed: June 17, 2010
    Date of Patent: July 22, 2014
    Assignees: Centre National de la Recherche Scientifique, Universite d'Orleans
    Inventors: Luigi A. Agrofoglio, Vincent Roy, Ugo Pradere
  • NOVEL ANTIVIRAL ACYCLIC NUCLEOSIDE PHOSPHONATES
    Publication number: 20130231307
    Abstract: Compounds of formula (I) wherein A represents a nucleobase or a derivative thereof, n is equal to 0 or 1 and R?, R? are carbonic chain, and R10 is hydrogen or a carbonic chain for their use as antiviral agents.
    Type: Application
    Filed: June 1, 2011
    Publication date: September 5, 2013
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, KATHOLIEKE UNIVERSITEIT LEUVEN-K.U. LEUVEN R&D, UNIVERSITE DE ORLEANS
    Inventors: Luigi A. Agrofoglio, Vincent Roy, Hugo Pradere, Jan Balzarini, Robert Snoeck, Graciela Andrei
  • PHOSPHONATES SYNTHONS FOR THE SYNTHESIS OF PHOSPHONATES DERIVATIVES SHOWING BETTER BIOAVAILABILITY
    Publication number: 20120142897
    Abstract: Synthons for the synthesis of phosphonates prodrugs POM and POC, especially for direct Cross Metathesis.
    Type: Application
    Filed: June 17, 2010
    Publication date: June 7, 2012
    Applicants: UNIVERSITE D'ORLEANS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Luigi A. Agrofoglio, Vincent Roy, Ugo Pradere
  • Uridine Derivatives as Antiviral Drugs Against a Flaviviridae, Especially Hcv
    Publication number: 20090004137
    Abstract: The invention relates to the use of an uridine derivative of formula (I); wherein —R1 represents monohalogenated alkynyl or dihalogenated alkenyl; —R2 is chosen from among hydrogen, hydroxyl, O-alkyl, O—CO alkyl and halogen; —R3 is chosen from among hydrogen, hydroxyl, O-alkyl, O—CO alkyl, halogen, SH, S-alkyl and N3; and —R4 is chosen from among hydroxyl, O-alkyl, O—CO alkyl, O-phosphate, O-diphosphate, O-triphosphate and O phosphonate, as well as its possible tautomers, its possible pharmaceutically acceptable addition salts with an acid or a base, and its N-oxide forms, for the preparation of a drug having antiviral activity against a Flaviviridae.
    Type: Application
    Filed: December 22, 2005
    Publication date: January 1, 2009
    Applicants: Institute National De La Sainte Et De La Rechderche Medicale, Centre National De La Recherche Sceintifique
    Inventors: Vincent Aucagne, Vanessa Escuret, Fabien Zoulim, David Durantel, Christian Trepo, Luigi Agrofoglio, Nicolas Joubert, Franck Amelard