Patents by Inventor Luigi Ambrosio

Luigi Ambrosio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180289043
    Abstract: The present invention provides methods, compositions and modified foods and foodstuffs useful for weight management and glycemic control.
    Type: Application
    Filed: April 2, 2018
    Publication date: October 11, 2018
    Inventors: Alessandro Sannino, Luigi Ambrosio, Eyal S. Ron, Yishai Zohar, Christian Demitri
  • Patent number: 10086014
    Abstract: The invention relates to a method for the preparation of a polymer hydrogel, comprising cross-linking a precursor comprising a hydrophilic polymer optionally in combination with a second hydrophilic polymer, using a polycarboxylic acid as the cross-linking agent. The invention further concerns the polymer hydrogel obtainable by the method of the invention and the use thereof in a number of different applications.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: October 2, 2018
    Assignee: GELESIS LLC
    Inventors: Alessandro Sannino, Luigi Ambrosio, Luigi Nicolais, Christian Demitri
  • Publication number: 20180214599
    Abstract: It is disclosed a biocomposite of hydroxyapatite on graphene oxide sheets and its use for bone tissue engineering applications, such as bone repair, bone augmentation, as well as coating of biomedical implants. Processes for preparing said biocomposites are also described.
    Type: Application
    Filed: July 26, 2016
    Publication date: August 2, 2018
    Applicants: CONSIGLIO NAZIONALE DELLE RICERCHE, JOINTHERAPEUTICS S.R.L.
    Inventors: Luigi Ambrosio, Maria Grazia Raucci, Angela Longo, Gianfranco Carotenuto, Daniela Giugliano
  • Publication number: 20160361350
    Abstract: The invention relates to a method for the preparation of a polymer hydrogel, comprising cross-linking a precursor comprising a hydrophilic polymer optionally in combination with a second hydrophilic polymer, using a polycarboxylic acid as the cross-linking agent. The invention further concerns the polymer hydrogel obtainable by the method of the invention and the use thereof in a number of different applications.
    Type: Application
    Filed: June 17, 2016
    Publication date: December 15, 2016
    Inventors: Alessandro Sannino, Luigi Ambrosio, Luigi Nicolais, Christian Demitri
  • Patent number: 8901202
    Abstract: Herein described is a biocompatible material comprising a polymer matrix based on hyaluronic acid derivatives and poly-?Caprolactone, the process for preparing this material, a prosthetic device constituted by this biocompatible material and a reinforcing material, the process for preparing the prosthetic device, and its use for the partial or total replacement of meniscus, and regeneration of the meniscal fibrocartilage.
    Type: Grant
    Filed: December 14, 2005
    Date of Patent: December 2, 2014
    Assignees: Anika Therapeutics S.r.l.
    Inventors: Andrea Pastorello, Luigi Ambrosio, Gennaro Tafuri, Alessandra Pavesio
  • Publication number: 20140296507
    Abstract: The invention relates to a method for the preparation of a polymer hydrogel, comprising cross-linking a precursor comprising a hydrophilic polymer optionally in combination with a second hydrophilic polymer, using a polycarboxylic acid as the cross-linking agent. The invention further concerns the polymer hydrogel obtainable by the method of the invention and the use thereof in a number of different applications.
    Type: Application
    Filed: January 8, 2014
    Publication date: October 2, 2014
    Applicant: GELESIS LLC
    Inventors: Alessandro Sannino, Luigi Ambrosio, Luigi Nicolais, Christian Demitri
  • Patent number: 8658147
    Abstract: The invention relates to a method for the preparation of a polymer hydrogel, comprising cross-linking a precursor comprising a hydrophilic polymer optionally in combination with a second hydrophilic polymer, using a polycarboxylic acid as the cross-linking agent. The invention further concerns the polymer hydrogel obtainable by the method of the invention and the use thereof in a number of different applications.
    Type: Grant
    Filed: February 10, 2010
    Date of Patent: February 25, 2014
    Assignee: Gelesis LLC
    Inventors: Alessandro Sannino, Luigi Ambrosio, Luigi Nicolais, Christian Demitri
  • Patent number: 8231909
    Abstract: The invention relates to a new injectable composite material suitable for use as a bone substitute. The composite material according to the invention comprises a reactive ceramic phase based on tricalcium phosphate and an organic phase comprising a polyvinyl alcohol hydrogel. By varying the concentration of the two phases it is possible to modulate the mechanical and injectability properties of the material.
    Type: Grant
    Filed: December 28, 2010
    Date of Patent: July 31, 2012
    Assignee: Consiglio Nazionale Delle Ricerche
    Inventors: Luigi Ambrosio, Valeria Sanginario, Maria Pau Ginebra, Josep Anton Planell
  • Publication number: 20120052151
    Abstract: The present invention provides methods, compositions and modified foods and foodstuffs useful for weight management and glycemic control.
    Type: Application
    Filed: May 13, 2011
    Publication date: March 1, 2012
    Inventors: Alessandro Sannino, Luigi Ambrosio, Eyal S. Ron, Yishai Zohar
  • Publication number: 20110091554
    Abstract: The invention relates to a new injectable composite material suitable for use as a bone substitute. The composite material according to the invention comprises a reactive ceramic phase based on tricalcium phosphate and an organic phase comprising a polyvinyl alcohol hydrogel. By varying the concentration of the two phases it is possible to modulate the mechanical and injectability properties of the material.
    Type: Application
    Filed: December 28, 2010
    Publication date: April 21, 2011
    Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Luigi AMBROSIO, Valeria SANGINARIO, Maria Pau GINEBRA, Josep Anton PLANELL
  • Publication number: 20110027364
    Abstract: A method of producing a soybean-based biomaterial which is suitable for use in a biomedical product, the method comprising: defatting soy flour; either prior to or at the same time as, performing a solvent extraction; to produce a biomaterial comprising variable levels of soy proteins, carbohydrates and isoflavones. The resulting biomaterials have a range of biomedical uses and are particularly desirable because of their isoflavone content. Examples of biomedical products containing the biomaterials include wound dressings; scaffolds for tissue engineering; fillers or implants for use in surgery; temporary barriers for use in dental or surgical procedures or to prevent post-surgical tissue adherence; carriers for the delivery of drugs, bioactive peptides or plasmids; anti-inflammatory agents; coatings for wound dressings or for dental, medical, surgical or veterinary devices or implants; and compositions for soothing skin or gum irritation.
    Type: Application
    Filed: November 26, 2008
    Publication date: February 3, 2011
    Applicant: UNIVERSITY OF BRIGHTON
    Inventors: Luigi Ambrosio, Luigi Nicolais, Jonathan Peter Salvage, Matteo Santin, Guy Standen
  • Publication number: 20100234233
    Abstract: The invention relates to a method for the preparation of a polymer hydrogel, comprising cross-linking a precursor comprising a hydrophilic polymer optionally in combination with a second hydrophilic polymer, using a polycarboxylic acid as the cross-linking agent. The invention further concerns the polymer hydrogel obtainable by the method of the invention and the use thereof in a number of different applications.
    Type: Application
    Filed: February 10, 2010
    Publication date: September 16, 2010
    Inventors: Alessandro Sannino, Luigi Ambrosio, Luigi Nicolais
  • Publication number: 20080227944
    Abstract: The invention relates to a method for the preparation of a superabsorbent polymer hydrogel, comprising the steps of (i) crosslinking a 3% overall aqueous solution of carboxymethylcellulose sodium salt and hydroxyethylcellulose with 5% carbodiimide, in the presence of an acid catalyst; (ii) washing the gel obtained at least once by swelling in a polar organic solvent; and (iii) drying the gel by phase inversion in a non-solvent for cellulose. The invention further concerns the superabsorbent hydrogels obtainable by said method and the uses thereof.
    Type: Application
    Filed: December 28, 2005
    Publication date: September 18, 2008
    Inventors: Luigi Ambrosio, Luigi Nicolais, Alessandro Sannino
  • Publication number: 20080220086
    Abstract: The invention relates to a new injectable composite material suitable for use as a bone substitute. The composite material according to the invention comprises a reactive ceramic phase based on tricalcium phosphate and an organic phase comprising a polyvinyl alcohol hydrogel. By varying the concentration of the two phases it is possible to modulate the mechanical and injectability properties of the material.
    Type: Application
    Filed: August 1, 2006
    Publication date: September 11, 2008
    Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Luigi Ambrosio, Valeria Sanginario, Maria Pau Ginebra, Josep Anton Planell
  • Publication number: 20080097605
    Abstract: Herein described is a biocompatible material comprising a polymer matrix based on hyaluronic acid derivatives and poly-?Caprolactone, the process for preparing this material, a prosthetic device constituted by this biocompatible material and a reinforcing material, the process for preparing the prosthetic device, and its use for the partial or total replacement of meniscus, and regeneration of the meniscal fibrocartilage.
    Type: Application
    Filed: December 14, 2005
    Publication date: April 24, 2008
    Inventors: Andrea Pastorello, Luigi Ambrosio, Gennaro Tafuri, Alessandra Pavesio
  • Publication number: 20040081698
    Abstract: The invention provides thermoplastic materials for biomedical applications through the processing of soybean de-fatted Tofu cheese. The material films show a relatively high degree of water uptake from the dry state as well as good tensile strength and elastic modulus when tested in wet conditions. The materials minimise in vitro the humoral and cell-mediated inflammatory response, promote the formation of calcium phosphate crystals and undergo a slow degradation in buffer systems. Adhesion and proliferation of tissue cells are favoured by this natural composite material.
    Type: Application
    Filed: June 9, 2003
    Publication date: April 29, 2004
    Inventors: Matteo Santin, Luigi Nicolais, Luigi Ambrosio
  • Patent number: 5645592
    Abstract: Provided are orthopedic fasteners and replacements such as nails, screws, pins, hip and knee replacements, etc., coated with hydrogels and other biocompatible/biodegradable materials which expand in the presence of liquids. Swelling of such coatings causes the fastener or replacement to be securely fixed into position once inserted into bone material. Useful coating materials include methacrylates, hyaluronic acid esters, and crosslinked esters of hyaluronic acid resulting from the esterification of hyaluronic acid with polyhydric alcohols. Also provided is a method for fixing a bone or bone replacement in position employing such coated orthopedic fasteners or replacements.
    Type: Grant
    Filed: April 27, 1995
    Date of Patent: July 8, 1997
    Assignee: M.U.R.S.T. Italian Ministry for Universities and Scientific and Technological Research
    Inventors: Luigi Nicolais, Luigi Ambrosio, Paolo Antonio Netti, Lanfranco Callegaro