Abstract: The present invention relates to a specific set of circulating protein and metabolite biomarkers for the diagnosis of Brugada Syndrome (BrS) in a human being and relative methods of detection. The invention further relates to mutated Prg4, Epx and Pon1 genes and related proteins for the prediction and diagnosis of Brugada Syndrome.

Abstract: The present invention relates to a specific set of circulating biomarkers and related methods and kits for the diagnosis of Brugada Syndrome in a human being.

Abstract: A computer-implemented method of facilitating electrocardiogram (“ECG”) analysis involves receiving one or more sensed ECG traces for a patient, each of the sensed ECG traces representing sensed patient heart activity over a sensed time period, and, for each of the one or more sensed ECG traces: identifying a plurality of corresponding sensed ECG trace segments, each of the sensed ECG trace segments representing sensed patient heart activity for the patient over a segment of the sensed time period, and determining a representative ECG trace based on at least one of the identified corresponding sensed ECG trace segments. The method involves causing at least one neural network classifier to be applied to the one or more determined representative ECG traces to determine one or more diagnostically relevant scores related to at least one diagnosis of the patient. Other methods, systems, and computer readable media are disclosed.

Abstract: A computer-implemented method of facilitating electrocardiogram (“ECG”) analysis involves receiving one or more sensed ECG traces for a patient, each of the sensed ECG traces representing sensed patient heart activity over a sensed time period, and, for each of the one or more sensed ECG traces: identifying a plurality of corresponding sensed ECG trace segments, each of the sensed ECG trace segments representing sensed patient heart activity for the patient over a segment of the sensed time period, and determining a representative ECG trace based on at least one of the identified corresponding sensed ECG trace segments. The method involves causing at least one neural network classifier to be applied to the one or more determined representative ECG traces to determine one or more diagnostically relevant scores related to at least one diagnosis of the patient. Other methods, systems, and computer readable media are disclosed.

Abstract: The inventors have made the surprising discovery that when ceramide production is upregulated in the infarct and at-risk areas upon reperfusion injury in the heart, such upregulation is effected through the de novo ceramide synthesis pathway. Upon treatment of cardiac tissues subject to reperfusion injury with a specific inhibitor of the novo ceramide synthesis pathway (myriocin), the inventors have determined that the inhibition of such pathway not only reduces the inflammation of the interested area, but most surprisingly reduces infarct size, ameliorates cardiac contractility and activates cell detoxification and survival programs. There is thus provided an inhibitor of de novo ceramide synthesis pathway, particularly myriocin, for the treatment of cardiac reperfusion injury.