Patents by Inventor Luigi Aurelio

Luigi Aurelio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SULFOXONIUM YLIDE DERIVATIVES AS PROBES FOR CYSTEINE PROTEASE
    Publication number: 20230285598
    Abstract: The present invention relates to compounds of formula I bearing a sulfoxoniumylide moiety as warhead, or salts thereof. Such compounds can be used as activity-based probes for cysteine proteases such as cathepsin X, in methods of detecting cysteine protease activity and in related diagnostic or therapeutic methods.
    Type: Application
    Filed: December 20, 2019
    Publication date: September 14, 2023
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Laura EDGINGTON-MITCHELL, Simon MOUNTFORD, Bethany M. ANDERSON, Monika SZABO, Luigi AURELIO, Philip THOMPSON
  • NOVEL ACTIVITY-BASED PROBES FOR NEUTROPHIL ELASTASE AND THEIR USE
    Publication number: 20230140838
    Abstract: The present invention relates to compounds of formula I, wherein D is a detectable moiety, or salts thereof, which can be used as activity-based probes for neutrophil elastase, as well as to methods for detecting neutrophil elastase (NE) activity in a tissue sample lysate, and related diagnostic methods using compounds of formula I.
    Type: Application
    Filed: December 20, 2019
    Publication date: May 4, 2023
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Laura EDGINGTON-MITCHELL, Bethany M. ANDERSON, Daniel P. POOLE, Luigi AURELIO, Paulina KASPERKIEWICZ, Marcin DRAG, Nigel BUNNETT
  • Tripartite Modulators of Endosomal G Protein-Coupled Receptors
    Publication number: 20230119819
    Abstract: The present invention relates to tripartite compounds comprising a modulator moiety for endosomal G protein-coupled receptors like neurokinin-1 receptor, a linker and a lipid anchor suitable for anchoring the tripartite compound into a plasma membrane. The present invention also relates to a prodrug and a pharmaceutical composition comprising the tripartite compound and the use of the tripartite compound for the treatment of a disease or disorder mediated by endosomal G protein-coupled receptors signalling like NK1R signalling.
    Type: Application
    Filed: May 6, 2022
    Publication date: April 20, 2023
    Inventors: Nigel W. Bunnett, Christopher John Porter, Derek Cole, Gareth Hicks, Junya Shirai, Gavin Hirst, Luigi Aurelio
  • Tripartite modulators of endosomal G protein-coupled receptors
    Patent number: 11324832
    Abstract: The present invention relates to tripartite compounds comprising a modulator moiety for endosomal G protein-coupled receptors like neurokinin-1 receptor, a linker and a lipid anchor suitable for anchoring the tripartite compound into a plasma membrane. The present invention also relates to a prodrug and a pharmaceutical composition comprising the tripartite compound and the use of the tripartite compound for the treatment of a disease or disorder mediated by endosomal G protein-coupled receptors signalling like NK1R signalling.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: May 10, 2022
    Assignee: Endosome Therapeutics, Inc.
    Inventors: Nigel W. Bunnett, Christopher John Porter, Derek Cole, Gareth Hicks, Junya Shirai, Gavin Hirst, Luigi Aurelio
  • NOVEL ACTIVITY-BASED PROBES FOR NEUTROPHIL ELASTASE AND THEIR USE
    Publication number: 20220050107
    Abstract: The present invention relates to compounds of formula I, wherein D is a detectable moiety, or salts thereof, which can be used as activity-based probes for neutrophil elastase, as well as to methods for detecting neutrophil elastase (NE) activity in a tissue sample lysate, and related diagnostic methods using compounds of formula I.
    Type: Application
    Filed: December 12, 2019
    Publication date: February 17, 2022
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Laura EDGINGTON-MITCHELL, Bethany M. ANDERSON, Daniel P. POOLE, Luigi AURELIO, Paulina KASPERKIEWICZ, Marcin DRAG, Nigel BUNNETT
  • Inhibitors of Protease Activated Receptor-2
    Publication number: 20200383985
    Abstract: The present invention relates generally to compounds capable of inhibiting Protease Activated Receptor-2 (PAR2), and uses thereof. More specifically, the present invention relates to inhibitors of PAR2, to their preparation, and to their use in the treatment of diseases and disorders mediated by PAR2 signaling.
    Type: Application
    Filed: December 19, 2018
    Publication date: December 10, 2020
    Inventors: Luigi Aurelio, Nigel W. Bunnett, Bernhard Luke Flynn, Le Giang
  • Enzyme interacting agents
    Patent number: 9828351
    Abstract: The present disclosure relates generally, but not exclusively, to compounds and their use as enzyme interacting agents, in particular, agents which interact with one or more enzymes in the sphingolipid biosynthesis pathway. The disclosure further relates to the use of such compounds as research tools, use in therapy, to compositions and agents comprising said compounds, and to methods of treatment using said compounds.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: November 28, 2017
    Assignees: MONASH UNIVERSITY, UNIVERSITY OF SOUTH AUSTRALIA, CENTRAL ADELAIDE LOCAL HEALTH NETWORK INCORPORATED
    Inventors: Bernard Luke Flynn, Luigi Aurelio, Carmen Vittoria Scullino, Bing Hui Wang, Stuart Maxwell Pitson, Melissa Rose Pitman
  • ENZYME INTERACTING AGENTS
    Publication number: 20170190698
    Abstract: The present disclosure relates generally, but not exclusively, to compounds and their use as enzyme interacting agents, in particular, agents which interact with one or more enzymes in the sphingolipid biosynthesis pathway. The disclosure further relates to the use of such compounds as research tools, use in therapy, to compositions and agents comprising said compounds, and to methods of treatment using said compounds.
    Type: Application
    Filed: June 26, 2015
    Publication date: July 6, 2017
    Inventors: Bernard Luke Flynn, Luigi Aurelio, Carmen Vittoria Scullino, Bing Hui Wang, Stuart Maxwell Pitson, Melissa Rose Pitman
  • N-methyl amino acids
    Publication number: 20050245432
    Abstract: The present invention relates to a compound of formula (I) or (II), processes for preparing them, peptides including them and kits involving them.
    Type: Application
    Filed: July 11, 2003
    Publication date: November 3, 2005
    Inventors: Luigi Aurelio, John Box, Robert Brownlee, Andrew Hughes