Patents by Inventor Luigi Filocamo

Luigi Filocamo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 17-alpha-substituted derivatives of estradiol with wound-healing activity
    Patent number: 8357675
    Abstract: The invention relates to 17?-(5-hydroxy-C5-hydrocarbyl)-1,3,5(10)-estratrien-3,17?-diol derivatives having cicatrising activity, preferably for topical use on wounds, without significant systemic effects, and to pharmaceutical compositions containing them. In particular, the invention relates to estradiol 17?-(5-hydroxypentyn-1-yl)derivatives and 3-esters, 5?-esters and 3,5?-diesters thereof and to a process for the preparation thereof by reaction of 3-OR-protected estrone with an alkali metal derivative of OR-protected 5-pentynol, followed by 3-, 5-? or 3,5?-esterifÊcation.
    Type: Grant
    Filed: July 28, 2006
    Date of Patent: January 22, 2013
    Assignee: Euticals S.p.A.
    Inventors: Gillian Ashcroft, Mario Brufani, Francesca Ceccacci, Paolo Maria Farina, Luigi Filocamo, Barbara Garofalo, Roberta Joudioux, Adriana Maggi, Rinaldo Marini Bettolo, Luisa Maria Migneco
  • 17-ALPHA-SUBSTITUTED DERIVATIVES OF ESTRADIOL WITH WOUND-HEALING ACTIVITY
    Publication number: 20100035796
    Abstract: The invention relates to 17?-(5-hydroxy-C5-hydrocarbyl)-1,3,5(10)-estratrien-3,17?-diol derivatives having cicatrising activity, preferably for topical use on wounds, without significant systemic effects, and to pharmaceutical compositions containing them. In particular, the invention relates to estradiol 17?-(5-hydroxypentyn-1-yl)derivatives and 3-esters, 5?-esters and 3,5?-diesters thereof and to a process for the preparation thereof by reaction of 3-OR-protected estrone with an alkali metal derivative of OR-protected 5-pentynol, followed by 3-, 5-? or 3,5?-esterification.
    Type: Application
    Filed: July 28, 2006
    Publication date: February 11, 2010
    Applicant: EUTICALS S.P.A.
    Inventors: Gillian Ashcroft, Mario Brufani, Francesca Ceccacci, Paolo Maria Farina, Luigi Filocamo, Barbara Garofalo, Roberta Joudioux, Adriana Maggi, Rinaldo Marini Bettolo, Luisa Maria Migneco
  • Phosphatidylinositol analogues, inhibitors of phosphatidylinositol specific phospholipase C
    Patent number: 5352810
    Abstract: Phosphatidylinositol analogues, inhibitors of phosphatidylinositol-specific phospholipase C of general formula (I) ##STR1## wherein X and R have the meanings specified in the description, suitable for preparing pharmaceutical compositions for the treatment of tumoral, thrombotic and inflammatory type pathologies.
    Type: Grant
    Filed: January 23, 1992
    Date of Patent: October 4, 1994
    Assignee: Mediolanum Farmaceutici S.p.A.
    Inventors: Mario Brufani, Maria Candida Cesta, Enrico Ferrari, Luigi Filocamo, Sperandina Lappa, Stefano Maiorana, Pier Giuseppe Pagella
  • Aminoalkylcarbamic esters of eseroline suitable for use as chlorinesterase activity inhibitors
    Patent number: 5302593
    Abstract: Aminoalkylcarbamic esters of eseroline suitable for use as cholinesterase activity inhibitors, having general formula (I) ##STR1## where R stands for an amine selected out of the group consisting of ##STR2## and n, R1, R2, R3, and R4 are as defined in the text.
    Type: Grant
    Filed: June 23, 1993
    Date of Patent: April 12, 1994
    Assignee: Mediolanum Farmaceutici S.p.A.
    Inventors: Maria A. Alisi, Mario Brufani, Maria C. Cesta, Luigi Filocamo, Gianluca Gostoli, Sperandina Lappa, Pier Giuseppe Pagella, Enrico Ferrari, Stefano Maiorana, Donata Marchesini