Patents by Inventor Luigi Petrucciani

Luigi Petrucciani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of fludarabine phosphate from 2-fluoroadenine and fludarabine phosphate salts with amines or ammonia
    Publication number: 20060240529
    Abstract: The invention provides a process for the preparation of fludarabine phosphate from 2-fluoroadenine and 9-?-D-arabinofuranosyl-uracil using Enterobacter aerogenes (EBA). 2-Fluoroadenine is reacted with 9-?-D-arabinosyl-uracile in a water solution at pH=7 in the presence of EBA cell paste, to yield fludarabine. Fludarabine is then treated with acetic anhydride and the resulting acetylderivative is crystallised and hydrolysed to fludarabine. Phosphorylation and purification with organic amines or with ammonium hydroxide afford fludarabine phosphate.
    Type: Application
    Filed: February 11, 2004
    Publication date: October 26, 2006
    Inventors: Paolo Farina, Luigi Petrucciani, Paolo Colombo, Giovanni Caprioli
  • Process for preparing 5?-acetylstavudine
    Patent number: 6350873
    Abstract: The present invention relates to a process for preparing 5′-acetylstavudine, an intermediate which is useful in the preparation of 2′,3′-didehydro-3′-deoxythymidine, an active principle with antiviral action which is commonly known as stavudine (D4T).
    Type: Grant
    Filed: April 12, 2001
    Date of Patent: February 26, 2002
    Assignee: Clariant Life Science Molecules (Italy) S.p.A.
    Inventors: Giorgio Bertolini, Marco Frigerio, Maurizio Velati, Luigi Petrucciani
  • Process for preparing 5'-acetylstavudine
    Publication number: 20010039342
    Abstract: The present invention relates to a process for preparing 5′-acetylstavudine, an intermediate which is useful in the preparation of 2′,3′-didehydro-3′-deoxythymidine, an active principle with antiviral action which is commonly known as stavudine (D4T).
    Type: Application
    Filed: April 12, 2001
    Publication date: November 8, 2001
    Inventors: Giorgio Bertolini, Marco Frigerio, Maurizio Velati, Luigi Petrucciani