Patents by Inventor Luigi Racioppi

Luigi Racioppi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CaMKK2 inhibitor compositions and methods of using the same
    Patent number: 12158399
    Abstract: Provided herein are compositions including a CaMKK2 inhibitor and an anti-cancer therapeutic agent and methods of treating cancer in a subject by administering a therapeutically effective amount of the composition to a subject. The subject may be selected for treatment based on an immune cell measurement of a sample from the subject. Methods of treating cancer by administering a therapeutically effective amount of a CaMKK2 inhibitor, and administering a therapeutically effective amount of an anti-cancer therapeutic agent to the subject are also provided. Kits including combination of a CaMKK2 inhibitor and another anti-cancer therapeutic agent are also provided.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: December 3, 2024
    Assignee: Duke University
    Inventors: Luigi Racioppi, Erik Nelson, Wei Huang, Nelson Chao, Donald McDonnell
  • COMPOSITIONS AND METHODS FOR PROMOTING HEMATOPOIETIC STEM CELL REGENERATION
    Publication number: 20230045325
    Abstract: Described is a method for promoting regeneration of hematopoietic stem and progenitor cells in a subject in need thereof. The method comprises administering to the subject a composition comprising a CaMKK2 inhibitor. The CaMKK2 inhibitor may be a small molecule inhibitor, such as STO-609.
    Type: Application
    Filed: August 1, 2022
    Publication date: February 9, 2023
    Inventor: Luigi Racioppi
  • Compositions and methods for promoting hematopoietic stem cell regeneration
    Patent number: 11426389
    Abstract: Described is a method for promoting regeneration of hematopoietic stem and progenitor cells in a subject in need thereof. The method comprises administering to the subject a composition comprising a Ca2+/calmodulin (CaM)-dependent protein kinase kinase 2 (CaMKK2) inhibitor. The CaMKK2 inhibitor may be a small molecule inhibitor, such as 7H-benzimidazo(2,1-a)benz(de)isoquinoline-7-one-3-carboxylic acid (STO-609).
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: August 30, 2022
    Assignee: Duke University
    Inventor: Luigi Racioppi
  • COMPOSITIONS AND METHODS FOR PROMOTING HEMATOPOIETIC STEM CELL REGENERATION
    Publication number: 20200268722
    Abstract: Described is a method for promoting regeneration of hematopoietic stem and progenitor cells in a subject in need thereof. The method comprises administering to the subject a composition comprising a Ca2+/calmodulin (CaM)-dependent protein kinase kinase 2 (CaMKK2) inhibitor. The CaMKK2 inhibitor may be a small molecule inhibitor, such as 7H-benzimidazo(2,1-a)benz(de)isoquinoline-7-one-3-carboxylic acid (STO-609).
    Type: Application
    Filed: July 27, 2018
    Publication date: August 27, 2020
    Inventor: Luigi Racioppi
  • CAMKK2 INHIBITOR COMPOSITIONS AND METHODS OF USING THE SAME
    Publication number: 20190167776
    Abstract: Provided herein are compositions including a CaMKK2 inhibitor and an anti-cancer therapeutic agent and methods of treating cancer in a subject by administering a therapeutically effective amount of the composition to a subject. The subject may be selected for treatment based on an immune cell measurement of a sample from the subject. Methods of treating cancer by administering a therapeutically effective amount of a CaMKK2 inhibitor, and administering a therapeutically effective amount of an anti-cancer therapeutic agent to the subject are also provided. Kits including combination of a CaMKK2 inhibitor and another anti-cancer therapeutic agent are also provided.
    Type: Application
    Filed: August 7, 2017
    Publication date: June 6, 2019
    Applicant: Duke University
    Inventors: Luigi RACIOPPI, Erik NELSON, Wei HUANG, Nelson CHAO, Donald MCDONNELL
  • T cell receptor ligands and methods of using same
    Patent number: 6900024
    Abstract: The present invention concerns TCR ligands with immunomodulatory properties, as well as methods of identifying such ligands and of using such ligands to modulate T cell effector responses.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: May 31, 2005
    Assignee: The United States of America as represented by the Secretary of the Department of Health & Human Services
    Inventors: Ronald N. Germain, Luigi Racioppi, Franca Ronchese-Le Gros
  • T cell receptor ligands and methods of using same
    Publication number: 20030077286
    Abstract: The present invention concerns TCR ligands with immunomodulatory properties, as well as methods of identifying such ligands and of using such ligands to modulate T cell effector responses.
    Type: Application
    Filed: July 10, 2002
    Publication date: April 24, 2003
    Inventors: Ronald N. Germain, Luigi Racioppi, Franca Ronchese-Le Gros
  • T cell receptor ligands and methods of using same
    Publication number: 20020187148
    Abstract: The present invention concerns TCR ligands with immunomodulatory properties, as well as methods of identifying such ligands and of using such ligands to modulate T cell effector responses.
    Type: Application
    Filed: July 10, 2002
    Publication date: December 12, 2002
    Inventors: Ronald N. Germain, Luigi Racioppi
  • T cell receptor ligands and methods of using same
    Publication number: 20010016198
    Abstract: The present invention concerns TCR ligands with immunomodulatory properties, as well as methods of identifying such ligands and of using such ligands to modulate T cell effector responses.
    Type: Application
    Filed: February 2, 2001
    Publication date: August 23, 2001
    Inventors: Ronald N. Germain, Luigi Racioppi, Franca Ronchese-Le Gros
  • T cell receptor ligands and methods of using same
    Publication number: 20010006792
    Abstract: The present invention concerns TCR ligands with immunomodulatory properties, as well as methods of identifying such ligands and of using such ligands to modulate T cell effector responses.
    Type: Application
    Filed: February 2, 2001
    Publication date: July 5, 2001
    Inventors: Ronald N. Germain, Luigi Racioppi, Franca Ronchese-Le Gros
  • T-cell receptor ligands and methods of using same
    Patent number: 5958712
    Abstract: The present invention concerns TCR ligands with immunomodulatory properties, as well as methods of identifying such ligands and of using such ligands to modulate T cell effector responses.
    Type: Grant
    Filed: May 19, 1997
    Date of Patent: September 28, 1999
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Ronald N. Germain, Luigi Racioppi
  • T cell receptor ligands and methods of using same
    Patent number: 5948409
    Abstract: The present invention concerns TCR ligands with immunomodulatory properties, as well as methods of identifying such ligands and of using such ligands to modulate T cell effector responses.
    Type: Grant
    Filed: May 19, 1997
    Date of Patent: September 7, 1999
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Ronald N. Germain, Luigi Racioppi
  • T cell receptor ligands and methods of using same
    Patent number: 5837477
    Abstract: The present invention concerns TCR ligands with immunomodulatory properties, as well as methods of identifying such ligands and of using such ligands to modulate T cell effector responses.
    Type: Grant
    Filed: January 15, 1993
    Date of Patent: November 17, 1998
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Ronald N. Germain, Luigi Racioppi, Franca Ronchese-Le Gros