Patents by Inventor Luigi Ratti

Luigi Ratti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the preparation of monohydrate
    Patent number: 5003064
    Abstract: Cefadroxil monohydrate is prepared by solubilizing 7-[D-(-)-.alpha.-benzyloxycarbonylamino-.alpha.-(p-hydroxyphenyl)acetamido ]-3-methyl-3-cephem-4-carboxylic acid by silylation or by salification in an organic solvent, subjecting the solubilized acid in the solvent to catalytic hydrogenation, separating the catalyst from the solution, and adding water to the solution at a pH of about 4 to precipitate cefadroxil monohydrate.
    Type: Grant
    Filed: February 23, 1989
    Date of Patent: March 26, 1991
    Assignee: Biochimica Opos SpA
    Inventors: Luigi Ratti, Leone Dall'Asta
  • Process for the prepartion of cefatrizine 1,2-propylene glycolate
    Patent number: 4965355
    Abstract: Cefatrizine 1,2-propylene glycolate is prepared by reacting p-hydroxyphenylglycine chloride hydrochloride with 7-amino-3-iodomethyl-3-cephem-4-carboxylic acid, and then reacting the thus obtained novel intermediate, 7-[D(-)-.alpha.-amino-.alpha.-(p-hydroxyphenyl)-acetamido]-3-iodomethyl-3- cephem-4-carboxylic acid, with the sodium salt of 1,2,3-triazol-4(5)-thiol in 1,2-propylene glycol. The addition of water to the reaction mixture causes the cefatrizine, 1,2-propylene glycolate to precipate.
    Type: Grant
    Filed: February 23, 1989
    Date of Patent: October 23, 1990
    Assignee: Biochimica OPOS SpA
    Inventors: Luigi Ratti, Leone Dall'Asta
  • Process for the preparation of 6-[D(-)alpha-(4-ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-alpha-phenyl acetamido]-penicillanic acid and intermediates useful in this process
    Patent number: 4837317
    Abstract: The 6-[D(-)-alpha(4-ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-alphaphenylace tamido]penicillanic acid and the salts thereof are prepared by synthetizing the novel intermediates, thioesters of D(-)-alpha-(4-ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-alpha-phenylacet ic acid, with mercaptoheterocycles and by converting them into the desired compound by reaction with 6-amino-penicillanic acid.
    Type: Grant
    Filed: October 5, 1987
    Date of Patent: June 6, 1989
    Assignee: Biochimica Opos S.p.A.
    Inventor: Luigi Ratti
  • Novel synthesis route for bacampicillin
    Patent number: 4619785
    Abstract: The novel compound .alpha.-bromodiethylcarbonate, its use in the preparation of 1-ethoxycarbonyloxyethyl esters of penicillins and cephalosporins, in particular bacampicillin, and improvements in the method for preparing such esters.
    Type: Grant
    Filed: June 23, 1983
    Date of Patent: October 28, 1986
    Assignee: Astra Lakemedel Aktiebolag
    Inventor: Luigi Ratti