Abstract: Several agents capable of inducing vascular responses akin to those observed in inflammatory processes enhance the accumulation of nanoparticles in tumors. Exemplary vascular-active agents include a bacterium, a pro-inflammatory cytokine, and microtubule-destabilizing drugs. Such agents can increase the tumor to blood ratio of radioactivity by more than 20-fold compared to nanoparticles alone. Moreover, vascular-active agents dramatically improved the therapeutic effect of nanoparticles containing radioactive isotopes or chemotherapeutic agents.

Abstract: Clinical management of human cancer is dependent on the accurate monitoring of residual and recurrent tumors. We have developed a method, called personalized analysis of rearranged ends (PARE), which can identify translocations in solid tumors. Analysis of four colorectal and two breast cancers revealed an average of nine rearranged sequences (range 4 to 15) per tumor. Polymerase chain reaction with primers spanning the breakpoints were able to detect mutant DNA molecules present at levels lower than 0.001% and readily identified mutated circulating DNA in patient plasma samples. This approach provides an exquisitely sensitive and broadly applicable approach for the development of personalized biomarkers to enhance the clinical management of cancer patients.

Abstract: The invention refers to compounds of general formula (I) having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.

Abstract: The present invention relates to new tetrahydro-?-carbolin-sulfonamide derivatives of general formula (I), optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their racemates or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or corresponding physiologically acceptable salts or corresponding solvates. These compounds are suitable as pharmacologically active agents in a medicament for the prophylaxis and/or treatment of disorders or diseases related to 5-HT6 receptors. The invention also relates to two different methods for obtaining the mentioned compounds and to pharmaceutical compositions containing them.

Abstract: Abnormal DNA methylation can be used as a biomarker in cancer patients. For such purposes, it is important to determine precisely the fraction of methylated molecules in an analyzed sample. A technology we term Methyl-BEAMing achieves this goal. Individual bisulfite-treated DNA molecules can be PCR-amplified within aqueous nanocompartments containing beads, resulting in a population of beads each containing thousands of copies of the template molecule. After hybridization with probes specific for methylated sequences, the beads can be analyzed by flow cytometry. This approach enables detection and enumeration of one methylated molecule in a population of ˜5000 unmethylated molecules. Methyl-BEAMing provides digital quantification of rare methylation events and is generally applicable to the assessment of methylated genes in clinical samples.

Abstract: The present invention is directed to a shoe and foot cleaning apparatus. The apparatus includes a mounting unit for installing the apparatus into the ground and an internal frame. Positioned onto the internal frame is a collection plate, a rotational drive system, a motor. The plurality of brush pads are removably positioned along the rotational drive system, and can travel along the path of the drive system. A portion of the brush pads can extend through a plurality of slots positioned at the top of the apparatus in order to clean the shoe and foot of a user.

Abstract: The present invention refers to substituted tetrahydro-quinoline-sulfonamide compounds of general formula (I): a method for their preparation, a medicament comprising these compounds and the use of substituted tetrahydro-quinoline-sulfonamide compounds for the preparation of medicaments for 5-HT6 receptor regulation as well as for the treatment of disorders related thereto.

Abstract: The present invention relates to heterocyclyl-substituted sulfonamides with 5-HT6 receptor affinity, and compositions thereof, and the use of said compounds for the treatment or prophylaxis of various disorders.

Abstract: Method for adapting radiofrequency signal spectrum, particularly in TETRA communications systems. The invention proposes using over-the-air signaling for communications systems according to the TETRA standard, to configure the characteristics of the radiofrequency signal, with the advantage that there is no loss of performance in data transmission speed and no need to change the type of modulation.

Abstract: The present invention relates to aryl-substituted sulfonamides with 5-HT6 receptor affinity, and compositions thereof, and the use of said compounds for the treatment or prophylaxis of various disorders.

Abstract: The present invention relates to heterocyclyl-substituted sulfonamides with 5-HT6 receptor affinity, and compositions thereof, and the use of said compounds for the treatment or prophylaxis of various disorders.

Abstract: DNA containing somatic mutations is highly tumor specific and thus, in theory, can provide optimum markers. However, the number of circulating mutant gene fragments is small compared to the number of normal circulating DNA fragments, making it difficult to detect and quantify them with the sensitivity required for meaningful clinical use. We apply a highly sensitive approach to quantify circulating tumor DNA (ctDNA) in body samples of patients. Measurements of ctDNA can be used to reliably monitor tumor dynamics in subjects with cancer, especially those who are undergoing surgery or chemotherapy. This personalized genetic approach can be generally applied.

Abstract: A suture anchor includes two clamping surfaces that secure one or more suture strands between them. Cooperating engaging structures, such as recesses and a projection enable the clamping surfaces to be incrementally moved closer together such that the force applied between the clamping surfaces is increased in predetermined increments to secure the suture strands. If the applied force is too high, the clamping surfaces can be released from a fixed position, and the force applied by the clamping surfaces can again be incrementally increased to the desired clamping force. A guide is provided to mark the location of the hole that has been drilled in the bone. A suture anchor delivery tool is provided to insert and secure the suture anchor in the hole in the bone. The suture anchor delivery tool enables the surgeon to move the clamping surfaces of the suture anchor towards each other.

Abstract: Device for the protection of electric lines which comprises: processing means; power supply means; voltage measurement means; means of alert; and switching means which alternatively send the line's own current through a main branch (which comprises the remaining components) or through a branch line; and method for the protection of electric lines by means of the device in accordance with the invention, which comprises: normal operating mode—safety element in perfect condition and inactive protection device; boundary anomalous operating mode—the intensity circulating through the safety element surpasses a caution threshold and the protection device signals said condition; and line verification anomalous operating mode—after failure of the safety element, all the current flows through the protection device and the protection device detects, signals, and analyses said condition.

Abstract: A medication delivery system that includes a housing and a reservoir fitted to the housing for storing the medication. A pump for delivering the medication is attached to the housing. Valves regulate fluid flow into and out of the pump. The valves are configured so that when fluid flows into the pump, flow out of the pump is blocked and, when flow into the pump is blocked, fluid can flow out of the pump. A port in communication with the reservoir serves as the conduit through which sterilization fluid is introduced into the reservoir and the pump. An actuator is attached to the housing. The actuator engages the valves to simultaneously hold both valves open. Thus, during sterilization, sterilization fluid simultaneously flows through into and out of the pump.

Abstract: The present invention refers to substituted tetrahydro-quinoline-sulfonamide compounds of general formula (I): a method for their preparation, a medicament comprising these compounds and the use of substituted tetrahydro-quinoline-sulfonamide compounds for the preparation of medicaments for 5-HT6 receptor regulation as well as for the treatment of disorders related thereto.

Abstract: The present invention relates to new tetrahydro-?-carbolin-sulfonamide derivatives of general formula (I), optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their racemates or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or corresponding physiologically acceptable salts or corresponding solvates. These compounds are suitable as pharmacologically active agents in a medicament for the prophylaxis and/or treatment of disorders or diseases related to 5-HT6 receptors. The invention also relates to two different methods for obtaining the mentioned compounds and to pharmaceutical compositions containing them.

Abstract: A method is shown for producing food grade hydrated lime. A source of raw, hydrated lime is first passed through a classification step which divides the raw hydrated lime into a first fine stream and a first coarse stream. The first fine stream is passed through a further separation step and, without being recombined with the first coarse stream is separated out to form a very fine sized product which meets CODEX chemical specifications. The additional separation step may be a wet process and may utilize a hydrocyclone type separator.

Abstract: A method (and structure) for displaying mapping relationships defined by a plurality of instruction elements, each instruction element providing a relation between zero or more source elements and zero or more result elements, where each source element includes one of a plurality of source elements and each result element includes one of a plurality of result elements, including providing a user a representation including a portion of the mapping relationships and including one or more of the plurality of source elements, the plurality of instruction elements, and the plurality of result elements. The user is provided a method to select one of the elements in the representation. The selected element is highlighted in the representation and the highlighting can be propagated to any other elements related by the mapping that are displayed in the representation.

Abstract: A method (and structure) for enacting changes to a document containing a template-based program that transforms tree-structured data from a first tree-structured data into a second tree-structured data, including providing an interface to permit selection of a document containing the template-based program, constructing a model of the template-based program in the selected document by parsing elements of the template-based program into a corresponding logical construct having a match condition and at least one generator, where the match condition determines whether an element in the first tree-structure data is to be processed by one or more of the at least one generator, and displaying a representation of the model to the user.