Abstract: The present invention refers to a liposome comprising: a) a phospholipid; b) cholesterol (chol); c) a conjugate comprising a cholesterol moiety, a polyethylene glycol (PEG) moiety and a peptide moiety comprising a RGD sequence, wherein the PEG moiety is covalently attached to the cholesterol moiety by one end via a bond of the type alkyl ether and is covalently attached to the peptide moiety comprising the RGD sequence by the other end: d) a non-lipid cationic surfactant present in a percentage of less than 30% mol in respect to the total mol of the components of the liposome a), b), c) and d); and e) alpha-galactosidase (GLA) enzyme present in a ratio of micrograms of GLA in respect to the total milligrams of the components of the liposome a), b), c) and d) of between and including 2 to 35. It also refers to a pharmaceutical composition that comprises it and to the liposome or the pharmaceutical composition for use as a medicament, in particular for use in the treatment of Fabry disease.

Abstract: A rotatable power strip outlet assembly that includes a power strip housing, a plurality of electrical sockets formed on a front surface of the power strip housing, and a rear plug support member rotatably coupled to the power strip housing, that includes a front surface, a rear surface, and an electrical plug disposed on the rear surface of the rear plug support member and with electrical prongs extending outwardly away from the rear surface of the rear plug support member and electrically coupled to the plurality of electrical sockets, wherein the power strip housing is operably configured to selectively rotate at least 270° with respect to the rear plug support member to reorient the power strip housing while plugged into an electrical outlet.

Abstract: A rotatable power strip outlet assembly that includes a power strip housing, a plurality of electrical sockets formed on a front surface of the power strip housing, and a rear plug support member rotatably coupled to the power strip housing, that includes a front surface, a rear surface, and an electrical plug disposed on the rear surface of the rear plug support member and with electrical prongs extending outwardly away from the rear surface of the rear plug support member and electrically coupled to the plurality of electrical sockets, wherein the power strip housing is operably configured to selectively rotate at least 270° with respect to the rear plug support member to reorient the power strip housing while plugged into an electrical outlet.

Abstract: A proton linear accelerator system that irradiates tissue with improved beam energy control, providing RF energy from a first RF energy source during on-time of the proton beam operating cycle for changing the energy of the proton beam, and providing RF energy from a second distinct RF energy source during off-time of the proton beam operating cycle for increasing or maintaining the temperature of the cavity. Each RF source is operated independently, allowing higher RF pulse rates to reach the cavity, supporting a smaller time between proton beam energy pulses. In addition, the peak power requirements for the second RF energy source may, in general, be less than for the second RF energy source, allowing a less costly type to be used for the second source. The use of a first and second RF source may reduce the cavity settling time from minutes to less than 10 seconds.

Abstract: Proton beams are a promising alternative to X-rays for therapeutic purposes because they may also destroy cancer cells, but with a greatly reduced damage to healthy tissue. The energy dose in tissue may be concentrated at the tumor site by configuring the beam to position the Bragg Peak proximate the tumor. The longitudinal range of a proton beam in tissue is generally dependent upon the energy of the beam. However, after switching energies, the proton-beam system requires some time for the beam energy to stabilize before it may be used for therapy. A proton linear accelerator system is provided for irradiating tissue with an improved beam energy control, configured to provide RF energy from a first RF energy source during the on-time of the proton beam operating cycle for changing the energy of the proton beam, and to provide RF energy from a second distinct RF energy source during the off-time of the proton beam operating cycle for increasing or maintaining the temperature of the cavity.

Abstract: Proton beams are a promising alternative to X-rays for therapeutic purposes because they may also destroy cancer cells, but with a greatly reduced damage to healthy tissue. The energy dose in tissue may be concentrated at the tumor site by configuring the beam to position the Bragg Peak proximate the tumor. The longitudinal range of a proton beam in tissue is generally dependent upon the energy of the beam. However, after switching energies, the proton-beam system requires some time for the beam energy to stabilize before it may be used for therapy. A proton linear accelerator system is provided for irradiating tissue with an improved beam energy control, configured to provide RF energy from a first RF energy source during the on-time of the proton beam operating cycle for changing the energy of the proton beam, and to provide RF energy from a second distinct RF energy source during the off-time of the proton beam operating cycle for increasing or maintaining the temperature of the cavity.

Abstract: Oxygen barrier compositions for electrical devices and their related methods are provided. In certain embodiments, the oxygen barrier compositions comprise a meta-substituted aromatic resin and an additional aromatic epoxy resin. In some embodiments, the compositions have a chlorine content of less than approximately 1000 ppm. The compositions may have an oxygen permeability of less than approximately 0.4 cm3·mm/m2·atm·day at approximately 0% relative humidity and approximately 23° C. In certain embodiments, methods of curing the oxygen barrier compositions comprise partially curing the composition where, the partial cure is achieved through ultraviolet radiation or heat.

Abstract: Oxygen barrier compositions for electrical devices and their related methods are provided. In certain embodiments, the oxygen barrier compositions comprise a meta-substituted aromatic resin and an additional aromatic epoxy resin. In some embodiments, the compositions have a chlorine content of less than approximately 1000 ppm. The compositions may have an oxygen permeability of less than approximately 0.4 cm3·mm/m2·atm·day at approximately 0% relative humidity and approximately 23° C. In certain embodiments, methods of curing the oxygen barrier compositions comprise partially curing the composition where, the partial cure is achieved through ultraviolet radiation or heat.

Abstract: Oxygen barrier compositions for electrical devices and their related methods are provided. In certain embodiments, the oxygen barrier compositions comprise a meta-substituted aromatic resin and an additional aromatic epoxy resin. In some embodiments, the compositions have a chlorine content of less than approximately 1000 ppm. The compositions may have an oxygen permeability of less than approximately 0.4 cm3·mm/m2·atm·day at approximately 0% relative humidity and approximately 23° C. In certain embodiments, methods of curing the oxygen barrier compositions comprise partially curing the composition where, the partial cure is achieved through ultraviolet radiation or heat.

Abstract: A surface-mountable electrical circuit protection device includes layers defining a first PPTC resistive element, a second PPTC resistive element, and at least one heat-generating electrical component such as a planar zener diode chip positioned between, and in thermal contact with, the first and second PPTC elements, such that an electrical current above a threshold level passing through the component causes the component to heat, the heat being transferred to the PPTC resistive elements and tripping at least one, and preferably both of the first or second PPTC elements to a high resistance state. A series of edge-formed terminal electrodes enable surface-mount connection of the first and second PPTC elements and the electrical component to an electrical circuit substrate, such as a printed circuit board. A method for making the device is also disclosed.

Abstract: A method for producing a surface mount device includes providing a plurality of layers including a B-staged top layer and bottom layer, and a C-staged middle layer with an opening. A core device is inserted into the openings, and then the top and bottom layers are placed over and under, respectively, the middle layer. The layers are cured until the layers become C-staged. The core device is substantially surrounded by an oxygen-barrier material with an oxygen permeability of less than approximately 0.4 cm3·mm/m2·atm·day.

Abstract: A method for producing a surface mount device includes providing a plurality of layers including a B-staged top layer and bottom layer, and a C-staged middle layer with an opening. A core device is inserted into the openings, and then the top and bottom layers are placed over and under, respectively, the middle layer. The layers are cured until the layers become C-staged. The core device is substantially surrounded by an oxygen-barrier material with an oxygen permeability of less than approximately 0.4 cm3·mm/m2·atm·day.

Abstract: An electrical component includes a plurality of core devices arranged within a housing so as to be electrically isolated from one another. For each of the plurality of core devices, a first contact pad and a second contact pad is formed on an outside surface of the housing. The first and second contact pads are electrically connected to a respective core device of the plurality of core devices.

Abstract: Determining and downloading portions of a software application in a computer system. The software application may include a plurality of portions. Which of those plurality of portions are currently present on the computer system and which of those plurality of portions are not currently present on the computer system may be determined. The portions of the software application which are not currently present on the computer system may be downloaded to the computer system. The portions of the software application which are currently present on the computer system may not be downloaded to the computer system.

Abstract: A surface-mountable electrical circuit protection device includes layers defining a first PPTC resistive element, a second PPTC resistive element, and at least one heat-generating electrical component such as a planar zener diode chip positioned between, and in thermal contact with, the first and second PPTC elements, such that an electrical current above a threshold level passing through the component causes the component to heat, the heat being transferred to the PPTC resistive elements and tripping at least one, and preferably both of the first or second PPTC elements to a high resistance state. A series of edge-formed terminal electrodes enable surface-mount connection of the first and second PPTC elements and the electrical component to an electrical circuit substrate, such as a printed circuit board. A method for making the device is also disclosed.

Abstract: A surface-mountable electrical circuit protection device includes layers defining a first PPTC resistive element, a second PPTC resistive element, and at least one heat-generating electrical component such as a planar zener diode chip positioned between, and in thermal contact with, the first and second PPTC elements, such that an electrical current above a threshold level passing through the component causes the component to heat, the heat being transferred to the PPTC resistive elements and tripping at least one, and preferably both of the first or second PPTC elements to a high resistance state. A series of edge-formed terminal electrodes enable surface-mount connection of the first and second PPTC elements and the electrical component to an electrical circuit substrate, such as a printed circuit board. A method for making the device is also disclosed.

Abstract: A method for producing a surface mount device includes providing a plurality of layers including a B-staged top layer and bottom layer, and a C-staged middle layer with an opening. A core device is inserted into the openings, and then the top and bottom layers are placed over and under, respectively, the middle layer. The layers are cured until the layers become C-staged. The core device is substantially surrounded by an oxygen-barrier material with an oxygen permeability of less than approximately 0.4 cm3·mm/m2·atm·day.

Abstract: Oxygen barrier compositions for electrical devices and their related methods are provided. In certain embodiments, the oxygen barrier compositions comprise a meta-substituted aromatic resin and an additional aromatic epoxy resin. In some embodiments, the compositions have a chlorine content of less than approximately 1000 ppm. The compositions may have an oxygen permeability of less than approximately 0.4 cm3·mm/m2·atm·day at approximately 0% relative humidity and approximately 23° C. In certain embodiments, methods of curing the oxygen barrier compositions comprise partially curing the composition where, the partial cure is achieved through ultraviolet radiation or heat.

Abstract: A new and distinct triploid Citrus hybrida cultivar is provided that is the product of controlled cross-pollination of two diploid parental plants. The new cultivar forms attractive obloid-shaped late-maturing substantially seedless fruit having an excellent mildly acidic flavor and a pleasant aroma. The leaves are dark green in coloration. The growth habit is vigorous and drooping.

Abstract: A new and distinct triploid Citrus hybrida cultivar is provided that is the product of controlled cross-pollination of two diploid parental plants. The new cultivar forms attractive seedless obloid-shaped, medium-late-maturing fruit with a convex base having an excellent mildly acidic flavor. The leaves are dark green in coloration. The growth habit is vigorous and erect-drooping.