Patents by Inventor Luis Alberto Diaz

Luis Alberto Diaz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR CANCER IMMUNOTHERAPY
    Publication number: 20230056846
    Abstract: In some embodiments the present invention provides methods useful for the treatment of MMR-proficient and/or microsatellite stable (MSS) cancers and also useful for enhancing the immunogenicity of MMR-proficient and/or microsatellite stable (MSS) cancer cells, enhancing the sensitivity of MMR-proficient and/or microsatellite stable (MSS) cancer cells to immune checkpoint blockade, inducing an MMR-deficient mutational signature in MMR-proficient and/or microsatellite stable (MSS) cancer cells, and/or increasing the frequency of both missense and InDel mutations in MMR-proficient and/or microsatellite stable (MSS) cancer cells. In some embodiments such methods involve administration of a combination of temozolomide and cisplatin, or a combination of temozolomide, cisplatin and an immune checkpoint inhibitor, to a subject in need thereof.
    Type: Application
    Filed: January 13, 2021
    Publication date: February 23, 2023
    Inventors: Luis Alberto Diaz, Benoit Rousseau, Neil H. Segal
  • Inhibition of Hsp27 phosphorylation for the treatment of blistering disorders
    Patent number: 8008093
    Abstract: A method of treating a blistering disorder, which includes administering to a target tissue in a subject in need thereof an effective amount of a composition that inhibits activation of the HSP27 phosphorylation pathway.
    Type: Grant
    Filed: December 2, 2005
    Date of Patent: August 30, 2011
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: David Scott Rubenstein, Paula Berkowitz, Peiqi Hu, Luis Alberto Diaz
  • Inhibition of Hsp27 Phosphorylation for the Treatment of Blistering Disorders
    Publication number: 20080207519
    Abstract: A method of treating a blistering disorder, which includes administering to a target tissue in a subject in need thereof an effective amount of a composition that inhibits activation of the HSP27 phosphorylation pathway.
    Type: Application
    Filed: December 2, 2005
    Publication date: August 28, 2008
    Inventors: David Scott Rubenstein, Paula Berkowitz, Peiqi Hu, Luis Alberto Diaz