Patents by Inventor Luis Angel Fernandez Herrero

Luis Angel Fernandez Herrero has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RECOMBINANT BACTERIUM AND USES THEREOF
    Publication number: 20240084312
    Abstract: The invention relates to a recombinant bacterium and uses thereof. In particular, it relates to the use of recombinant bacteria to translocate cargo proteins into the cytosol of target cells. Said recombinant bacteria comprises a T3 secretion system under the control of a genetic regulatory circuit and a targeting module which allow the recombinant bacteria to target specific cells, adhere to these and inject their cargo into the cytosol of the target cells.
    Type: Application
    Filed: December 20, 2021
    Publication date: March 14, 2024
    Inventors: Alejandro ASENSIO CALAVIA, Beatriz ÁLVAREZ GONZÁLEZ, Luis Ángel FERNÁNDEZ HERRERO
  • Systems, methods and microrganisms for antibody production with type III secretion system
    Patent number: 8623349
    Abstract: Exemplary embodiments disclosed herein include a microorganism that produces, secretes and injects recombinant antibodies into eukaryote cells said the described microorganisms can be used to prepare pharmaceutical compositions for the treatment of human or veterinary diseases.
    Type: Grant
    Filed: March 12, 2008
    Date of Patent: January 7, 2014
    Assignee: Consejo Superior de Investigaciones Cientificas
    Inventors: Luis Angel Fernandez Herrero, Ana Blanco Toribio
  • SYSTEMS, METHODS AND MICRORGANISMS FOR ANTIBODY PRODUCTION WITH TYPE III SECRETION SYSTEM
    Publication number: 20100120124
    Abstract: Exemplary embodiments disclosed herein include a microorganism that produces, secretes and injects recombinant antibodies into eukaryote cells said the described microorganisms can be used to prepare pharmaceutical compositions for the treatment of human or veterinary diseases.
    Type: Application
    Filed: March 12, 2008
    Publication date: May 13, 2010
    Applicant: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
    Inventors: Luis Angel Fernandez Herrero, Ana Blanco Toribio
  • GENERATION OF SPECIFIC ADHESION IN GRAM-NEGATIVE BACTERIA BY MEANS OF ANCHORING IMMUNOGLOBULIN SINGLE DOMAINS ON THEIR SURFACE WITH AUTOTRANSPORTERS
    Publication number: 20090155849
    Abstract: The present invention refers to an expression vector for gram-negative bacteria allowing for the production of hybrid proteins between single domain recombinant antibodies and a transporter domain of an autotransporter, as well as to its anchoring and expression on the external surface of a bacterial membrane, and to a method of specific bacterial adhesion to a surface containing a specific antigen.
    Type: Application
    Filed: January 13, 2005
    Publication date: June 18, 2009
    Applicant: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
    Inventors: Esteban Veiga Chacon, Victor De Lorenzo Prieto, Luis Angel Fernandez Herrero
  • System For the Production of Dimeric Proteins Based on the Transport System of Hemolysin of Escherichia Coli
    Publication number: 20080280346
    Abstract: The system comprises a DNA construct comprising: a) a first nucleic acid sequence containing the nucleotide sequence coding for a product of interest; b) a second nucleic acid sequence containing the nucleotide sequence coding for a dimerization domain; and c) a third nucleic acid sequence containing the nucleotide sequence coding for Escherichia coli ?-hemolysin (HlyA) or for a fragment of said protein comprising the recognition signal of the E. coli hemolysin (Hly) transport system secretion mechanism. It is applicable in producing recombinant dimeric proteins.
    Type: Application
    Filed: July 19, 2004
    Publication date: November 13, 2008
    Inventors: Victor de Lorenzo Prieto, Luis Angel Fernandez Herrero