Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

Abstract: The present disclosure provides a compound comprising a modified tetracycline derivative, covalently coupled through a linker to a low-hydrophobicity bioactive molecule useful for treating neurodegenerative diseases, wherein the modified tetracycline derivative is optionally defined by the following formula:

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

Abstract: A heat exchanger includes a heat exchanger shell formed from a first metal material, and a plurality of heat exchanger tubes extending through a plurality of tube openings in the heat exchanger shell. The plurality of heat exchanger tubes are formed from a second metal material different from the first metal material. A galvanic isolator is located at each tube opening of the plurality of tube openings, radially between the tube opening and the corresponding heat exchanger tube of the plurality of heat exchanger tubes. The galvanic isolator is configured to mitigate a galvanic reaction between the heat exchanger shell and the plurality of heat exchanger tubes.

Abstract: A swaging tool for use with a non-circular heat exchange tube including a body having a first sealing surface positionable in contact with the heat exchange tube to form a first seal with the heat exchange tube and a second sealing surface positionable in contact with the heat exchange tube to form a second seal with the heat exchange tube. At least one fluid channel is formed in the body and is connected to an outlet port. The outlet port is arranged between the first sealing surface and the second sealing surface.

Abstract: A tube bundle assembly includes at least one tube and a baffle. The baffle includes at least one hole for receiving the at least one tube. The at least one hole has a non-uniform diameter such that only a portion of a periphery of the at least one hole is positionable in contact with the at least one tube.

Abstract: The present disclosure provides a compound comprising a modified tetracycline derivative, covalently coupled through a linker defined by the generic formula XZX to a low-hydrophobicity bioactive molecule useful for treating neurodegenerative diseases, particularly a compound wherein the modified tetracycline derivative is a chemically modified doxycycline derivative and the low-hydrophobicity bioactive molecule useful for treating neurodegenerative diseases is dopamine. The disclosure also provides a process for preparing such compound, as well as methods for treating a neurodegenerative disease comprising administering said compound.

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

Abstract: Systems, devices, and methods for a novel computing device and method for enabling users to receive data regarding specific events based on the date, location, and artist performing at the event. A user can then select the desired event based on the criteria provided by the computing device. The user can determine which event reservation he or she wishes to join from a selection of event reservations already established by other users.

Abstract: A form to be used in creating a design in a yard and the method of installation of the design.

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

Abstract: Techniques are described for initiating a video conference between two video conferencing devices by leveraging information obtained from two mobile phones that are engaged in a mobile phone session with one another and are each associated with a respective one of the video conferencing devices. A video conferencing device may obtain the information, including the telephone numbers for both mobile phones, using a Bluetooth connection between the mobile phone and the video conferencing device. A data center receives and maintains the mobile phone session information, determines whether each mobile phone engaged in the mobile phone session is associated with an available video conferencing device, and, if so, invites the associated video conferencing devices to initiate a video conference with one another.

Abstract: A method for providing video content to a subscriber while minimizing transmission channel capacity that includes acquiring information corresponding to factors contributing to a perceived picture quality at a display device in communication with a set-top box, compressing video content based on the acquired information, and transmitting over a local loop the compressed video content at a bit rate based on the acquired information, the bit rate corresponding to the perceived picture quality of the video content capable of being provided by an ensemble comprised of the display device, the set-top box, and the local loop.

Abstract: Optimizing data rates for video services on a broadband network. Different data rates can be delivered to a subscriber premises depending on the size of the display screen connected to a set-top box, the type of content being requested, or whether there is real-time viewing. Therefore, the data rate can be optimized to maximize the number of video streams that can be delivered to any one subscriber without causing a perceived reduction in video picture quality.

Abstract: A method for optimizing data rates for video services to a subscriber that includes receiving an indication of whether incoming video signals to a set-top box corresponding to the subscriber are being recorded, receiving an indication of whether video content corresponding to the video signals being recorded is being simultaneously viewed by the subscriber, and reducing a data rate for storing the video content that is not simultaneously being viewed by the subscriber.

Abstract: A method for optimizing data rates for video services to a subscriber that includes receiving an indication of whether incoming video signals to a set-top box corresponding to the subscriber are being recorded, receiving an indication of whether video content corresponding to the video signals being recorded is being simultaneously viewed by the subscriber, and reducing a data rate for storing the video content that is not simultaneously being viewed by the subscriber.

Abstract: A method for providing video content to a subscriber while minimizing transmission channel capacity that includes acquiring information corresponding to factors contributing to a perceived picture quality at a display device in communication with a set-top box, compressing video content based on the acquired information, and transmitting over a local loop the compressed video content at a bit rate based on the acquired information, the bit rate corresponding to the perceived picture quality of the video content capable of being provided by an ensemble comprised of the display device, the set-top box, and the local loop.

Abstract: In a resource manager, a method for managing bandwidth allocation to a plurality of subscribers utilizing opportunistic bandwidth including tracking a bandwidth utilization on multiple links, receiving a request for services along one of the links, and selecting a video data rate on the one of the links that meets available bandwidth.