Abstract: This invention describes ways of obtaining nano-particulated adjuvants formed by different synthetic variants of GM3 ganglioside. Depending on the fine structure of the fatty acid in the ceramide of the synthetic GM3, said adjuvants are able to stimulate specifically and in a specialized way the humoral or cellular immune response against accompanying antigens. Particularly, this invention provides immunogenic vaccine compositions that comprise peptides, polypeptides or proteins and the aforementioned nanoparticles, which are formed through the dispersion of hydrophobic proteins of the outer membrane complex (OMC) of Neisseria meningitidis in solutions containing fully synthetic variants of the GM3 ganglioside.

Abstract: A guidance system, a method and a device for dynamically guiding a surgical needle catheter onto an organ to be surgically operated of a patient. In particular, the disclosure relates to a guidance system, a method and a device to aid in the percutaneous kidney puncture.

Abstract: The embodiments herein describe a CDN that uses revalidation to force edge servers to refresh their cached objects (i.e., download new copies of the objects from the origin data center). Revalidation can be used by edge servers to determine whether an object currently cached at the edge servers has been updated or changed in the origin data center. The embodiments herein leverage revalidation to perform a forced refresh to force the edge servers to refresh their cached object, regardless whether those cached objects match the objects stored in the origin data center. A forced refresh can be used when there is a network connection that may have caused the cached objects to become corrupted. Moreover, the forced refresh can be performed in batches so as not to overwhelm the network and computing resources in the CDN.

Abstract: The invention relates to antibody conjugates comprising an antibody and a nanoparticle conjugated to the antibody, wherein the nanoparticle comprises a payload, such as a gene editing payload. In some embodiments, the antibody-conjugated nanoparticles provide a means for treating a disease. In some embodiments, the antibody-conjugated nanoparticles are used to correct genetic defects in specific cell populations.

Abstract: A method and system for training and applying at least two neural networks for matching prospective students to institutions is disclosed This method and system enhances access to high-quality, affordable postsecondary education by predicting the likelihood of success that a given student will have at an institution. This is accomplished by predicting the similarity between a student and institution alumni on both objective and subjective criteria.

Abstract: An approach for assembling a hard drive to a hard drive carrier is provided. The approach includes an ergonomic tool to aid with assembly. The ergonomic tool allows for a reduction in assembly time and prevents damage to the components. The ergonomic tool comprising of a base having a first surface and a first end open for receiving the components. The tool has a set of walls rising from the base, a first wall rising from the base proximate a second end opposite the first end and a pair of opposing side walls including voids rising from the first surface between the first end and the second end, to form a slot there between to receive the components within and adjacent the first surface. The tool has a releasable hold mechanism that aligns the components during assembly.

Abstract: The embodiments herein describe a CDN that uses revalidation to force edge servers to refresh their cached objects (i.e., download new copies of the objects from the origin data center). Revalidation can be used by edge servers to determine whether an object currently cached at the edge servers has been updated or changed in the origin data center. The embodiments herein leverage revalidation to perform a forced refresh to force the edge servers to refresh their cached object, regardless whether those cached objects match the objects stored in the origin data center. A forced refresh can be used when there is a network connection that may have caused the cached objects to become corrupted. Moreover, the forced refresh can be performed in batches so as not to overwhelm the network and computing resources in the CDN.

Abstract: A tool for bending cable comprising a web forming a base having an upper surface, a lower surface, first edge, second edge, a first area of the base defining a bend member portion and a second area of the base defining a hand hold portion. The tool further comprising a set of wire gauge measuring intervals is integral with the first edge in the second area. The tool further comprising a set of bend members is arranged in a raised diminishing hierarchy on the upper surface in the first area, forming a cable bend radius gauge.

Abstract: A moldable photovoltaic module is provided. The module includes a flexible polymeric flex-circuit substrate having an electrically conductive printed wiring pattern and solder pads defined on it. Small photovoltaic cells are affixed to the flex-circuit substrate by back-surface contacts in electrical contact with the solder pads. At least one thermoformable polymeric film is joined to the flex-circuit substrate. Each said solder pad comprises a solder composition that, after an initial melt, has a melting point that lies above at least a portion of the temperature range for thermoforming the polymeric film.

Abstract: The embodiments herein describe a CDN that uses revalidation to force edge servers to refresh their cached objects (i.e., download new copies of the objects from the origin data center). Revalidation can be used by edge servers to determine whether an object currently cached at the edge servers has been updated or changed in the origin data center. The embodiments herein leverage revalidation to perform a forced refresh to force the edge servers to refresh their cached object, regardless whether those cached objects match the objects stored in the origin data center. A forced refresh can be used when there is a network connection that may have caused the cached objects to become corrupted. Moreover, the forced refresh can be performed in batches so as not to overwhelm the network and computing resources in the CDN.

Abstract: A tool for bending cable comprising a web forming a base having an upper surface, a lower surface, first edge, second edge, a first area of the base defining a bend member portion and a second area of the base defining a hand hold portion. The tool further comprising a set of wire gauge measuring intervals is integral with the first edge in the second area. The tool further comprising a set of bend members is arranged in a raised diminishing hierarchy on the upper surface in the first area, forming a cable bend radius gauge.

Abstract: An approach for assembling a hard drive to a hard drive carrier is provided. The approach includes an ergonomic tool to aid with assembly. The ergonomic tool allows for a reduction in assembly time and prevents damage to the components. The ergonomic tool comprising of a base having a first surface and a first end open for receiving the components. The tool has a set of walls rising from the base, a first wall rising from the base proximate a second end opposite the first end and a pair of opposing side walls including voids rising from the first surface between the first end and the second end, to form a slot there between to receive the components within and adjacent the first surface. The tool has a releasable hold mechanism that aligns the components during assembly.

Abstract: A vaccine RNA-peptide against SARS-CoV-2, which has a messenger ribonucleic acid (mRNA) having an open reading frame encoding a peptide of a Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) surface protein. The peptide of the severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) surface protein is fused to a synthetic poly ADP-ribose polymerase peptide. The vaccine RNA-peptide against SARS-CoV-2 has endogenous exosomes as carrier.

Abstract: High performance single crystal silicon cells and arrays thereof are manufactured using a rapid process flow. Tunneling junctions formed in the process provide performance benefits, such as higher efficiency and a lower power temperature coefficient. The process generates a large array of interconnected high performance cells smaller than typical cells without requiring additional process steps, and simplifies integration of these coupons into the final product. The cells can have different shapes, sizes, and orientations, enabling the array to be flexible in any desired direction. Higher efficiencies and lower hot spotting under shading is achieved by connecting small low current, high voltage cells in dense series and parallel configurations. Low current cells also require much less metallization than typical solar cells and arrays.

Abstract: A modular cable backplane assembly for high-speed interconnection of digital electrical components in Field Replaceable Units, FRUs, (12) mounted in an equipment rack (10). A vertical stack of a plurality of parallel horizontal cable connector carrying trays (51) is mounted within a rigid chassis (32). The trays provide electrical component connector pins on a front side and high-speed data and power cable connectors on a back side thereof. At least one enclosed vertical channel (21) is attached to the vertical stack of horizontal plates (51) for protectively routing cables to the cable connector carrying trays. Vertical spacing of the cable connector carrying trays enables cooling fans (41) mounted on the rigid chassis to provide unimpeded front-to-back airflow over the FRUs (12). The cable backplane assembly may be removed and replaced as a unit, and may be upgraded, in situ, from copper to optical connections.

Abstract: An apparatus to facilitate pixel compression is disclosed. The apparatus includes a rasterizer module to convert an image to a plurality of pixels, an interface coupled to the rasterizer module, a depth check module coupled to the interface and compression logic to perform a compression encoding on the plurality of pixels, including dividing the plurality of pixels into a mega pixel block having a plurality of pixel blocks, determining coverage information for pixels in each of the plurality of pixel blocks, encoding each of the plurality of pixel blocks based on the coverage information to generate a mega encoded block.

Abstract: A method, system and apparatus including a device cell having a top side, a bottom side and opposing side walls. A passivation layer is formed along the top side, the bottom side and opposing side walls of the device cell. The passivation layer serves to passivate the device cell and facilitate carrier collection around the device cell. An anti-reflective layer is formed over the passivation layer and an optical layer is formed on the top side of the device cell. The optical layer reflects light within the device cell. The apparatus may further include a reflective layer formed along the bottom side of the device cell, the reflective layer to reflect light internally within the device cell.

Abstract: A modular cable backplane assembly for high-speed interconnection of digital electrical components in Field Replaceable Units, FRUs, (12) mounted in an equipment rack (10). A vertical stack of a plurality of parallel horizontal cable connector carrying trays (51) is mounted within a rigid chassis (32). The trays provide electrical component connector pins on a front side and high-speed data and power cable connectors on a back side thereof. At least one enclosed vertical channel (21) is attached to the vertical stack of horizontal plates (51) for protectively routing cables to the cable connector carrying trays. Vertical spacing of the cable connector carrying trays enables cooling fans (41) mounted on the rigid chassis to provide unimpeded front-to-back airflow over the FRUs (12). The cable backplane assembly may be removed and replaced as a unit, and may be upgraded, in situ, from copper to optical connections.

Abstract: A method is provided for making a molded photovoltaic module. The module includes a flexible polymeric flex-circuit substrate having an electrically conductive printed wiring pattern and solder pads defined on it. Small photovoltaic cells are affixed to the flex-circuit substrate by back-surface contacts in electrical contact with the solder pads. At least one thermoformable polymeric film is joined to the flex-circuit substrate. Each said solder pad comprises a solder composition that, after an initial melt, has a melting point that lies above at least a portion of the temperature range for thermoforming the polymeric film.

Abstract: An apparatus to facilitate pixel compression is disclosed. The apparatus includes a rasterizer module to convert an image to a plurality of pixels, an interface coupled to the rasterizer module, a depth check module coupled to the interface and compression logic to perform a compression encoding on the plurality of pixels, including dividing the plurality of pixels into a mega pixel block having a plurality of pixel blocks, determining coverage information for pixels in each of the plurality of pixel blocks, encoding each of the plurality of pixel blocks based on the coverage information to generate a mega encoded block.