Patents by Inventor Luis Felipe Barros Olmedo

Luis Felipe Barros Olmedo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genetically encoded probe for quantification of lactate and methods for quantifying metabolic rates and lactate transport
    Patent number: 10466233
    Abstract: A nanosensor for detecting and quantifying lactate in different types of samples, such as tissues, intra-cellular and subcellular compartments, with high spatial and temporal resolution is disclosed. Methods comprising use of the nanosensor for quantifying the activity of lactate transporters, rates of cellular lactate production and cellular lactate consumption, and rate of mitochondrial pyruvate consumption are also disclosed. Methods for quantifying the transformation in energy metabolism that characterizes cancer cells with single-cell resolution and for detecting interference of candidate drugs with mitochondrial energetics are additionally disclosed.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: November 5, 2019
    Assignees: CENTRO DE ESTUDIOS CIENTIFICOS DE VALDIVIA, CARNEGIE INSTITUTION OF WASHINGTON
    Inventors: Luis Felipe Barros Olmedo, Alejandro San Martin, Sebastian Ceballo Charpentier, Wolf B. Frommer
  • GENETICALLY ENCODED PROBE FOR QUANTIFICATION OF LACTATE AND METHODS FOR QUANTIFYING METABOLIC RATES AND LACTATE TRANSPORT
    Publication number: 20150072375
    Abstract: A nanosensor for detecting and quantifying lactate in different types of samples, such as tissues, intra-cellular and subcellular compartments, with high spatial and temporal resolution is disclosed. Methods comprising use of the nanosensor for quantifying the activity of lactate transporters, rates of cellular lactate production and cellular lactate consumption, and rate of mitochondrial pyruvate consumption are also disclosed. Methods for quantifying the transformation in energy metabolism that characterizes cancer cells with single-cell resolution and for detecting interference of candidate drugs with mitochondrial energetics are additionally disclosed.
    Type: Application
    Filed: April 13, 2012
    Publication date: March 12, 2015
    Applicants: CARNEGIE INSTITUTION OF WASHINGTON, CENTRO DE ESTUDIOS CIENTIFICOS DE VALDIVIA
    Inventors: Luis Felipe Barros Olmedo, Alejandro San Martin, Sebastian Ceballo Charpentier, Wolf B. Frommer