Patents by Inventor Luis Fernando Romero Millán
Luis Fernando Romero Millán has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11931385Abstract: A feed additive composition comprising a direct fed microbial (DFM), in combination with a xylanase (e.g. endo-1,4-?-d-xylanase) and a ?-glucanase (and optionally a further fibre degrading enzyme).Type: GrantFiled: July 6, 2021Date of Patent: March 19, 2024Assignee: DUPONT NUTRITION BIOSCIENCES APSInventors: Mai Faurschou Isaksen, Marion Bernardeau, Luis Fernando Romero Millan, Elijah G. Kiarie, Susan Lund Arent, Päivi Nurminen, Sofia Forssten, Daniel Petri, Elizabeth Ann Galbraith, Mari Ellen Davis
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Publication number: 20230093634Abstract: The present invention relates to a method for solubilising arabinoxylan-containing material (particularly insoluble arabinoxylan-containing material), comprising admixing a xylan-containing material with a xylanase comprising a polypeptide sequence shown herein as SEQ ID No. 3, SEQ ID No. 2, SEQ ID No. 1, SEQ ID No. 9, SEQ ID No. 10. SEQ ID No. 11 or SEQ ID No. 15, or a variant, homologue, fragment or derivative thereof having at least 75% identity with SEQ ID No. 3 or SEQ ID No. 2 or SEQ ID No. 1 or SEQ ID No. 9 or SEQ ID No. 10 or SEQ ID No. 11 or SEQ ID No. 15; or a polypeptide sequence which comprises SEQ ID No. 3, SEQ ID No. 2, SEQ ID No. 1, SEQ ID No. 9, SEQ ID No. 10. SEQ ID No. 11 or SEQ ID No. 15 with a conservative substitution of at least one of the amino acids; or a xylanase which is encoded by a nucleotide sequence shown herein as SEQ ID No. 6, SEQ ID No. 5, SEQ ID No. 4, SEQ ID No. 12. SEQ ID No. 13. SEQ ID No. 14. SEQ ID No. 16. SEQ ID No. 17 or SEQ ID No.Type: ApplicationFiled: September 1, 2022Publication date: March 23, 2023Inventors: Luis Fernando Romero Millan, Susan Arent Lund, Brian Soegaard Laursen, Elijah Gituanjah Kiarie, Zhenghong Zhang, Rosalyn Lau, Zheyong Yu, Floor Klaaske Kooy, Jan Hendrik Van Tuijl, Bart Christiaan Koops, Mads Brogger Pedersen, Soren Dalsgaard
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Publication number: 20220218001Abstract: Novel superoxide dismutases of fungal origin are active, gastric stable and thermal stable, and effective for use in animal feed additives. The use of superoxide dismutase in animal feed improve animal growth, animal health and intestinal health of animals.Type: ApplicationFiled: April 5, 2020Publication date: July 14, 2022Applicant: Novozymes A/SInventors: Ming Li, Marianne Thorup Cohn, Kirk Matthew Schnorr, Elodie Bacou, Luis Fernando Romero Millan, Maria Walsch, Tianqi Sun, Ye Liu, Lan Tang, Estefania Perez Calvo, Peter Wagner
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Publication number: 20220183322Abstract: Novel polypeptides of fungal origin with catalase active are active, gastric stable and thermal stable, and effective for use in animal feed additives.Type: ApplicationFiled: April 5, 2020Publication date: June 16, 2022Applicant: Novozymes A/SInventors: Ming Li, Kirk Matthew Schnorr, Ye Liu, Lan Tang, Elodie Bacou, Luis Fernando Romero Millan, Maria Walsch, Estefania Perez Calvo, Peter Wagner
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Publication number: 20220040241Abstract: A feed additive composition comprising a direct fed microbial (DFM), in combination with a xylanase (e.g. endo-1,4-?-d-xylanase) and a ?-glucanase (and optionally a further fibre degrading enzyme).Type: ApplicationFiled: July 6, 2021Publication date: February 10, 2022Applicant: DUPONT NUTRITION BIOSCIENCES APSInventors: Mai Faurschou Isaksen, Marion Bernardeau, Luis Fernando Romero Millan, Elijah G. Kiarie, Susan Arent Lund, Päivi Nurminen, Sofia Forssten, Daniel Petri, Elizabeth Ann Galbraith, Mari Ellen Davis
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Patent number: 11172693Abstract: A feed additive composition comprising a direct fed microbial in combination with a protease, and a phytase, and a method for improving the performance of a subject or for improving digestibility of a raw material in a feed (e.g. nutrient digestibility, such as amino acid digestibility), or for improving nitrogen retention, or for improving the subject's resistance to necrotic enteritis or for improving feed conversion ratio (FCR) or for improving weight gain in a subject or for improving feed efficiency in a subject or for modulating (e.g. improving) the immune response of the subject or for promoting the growth of beneficial bacteria in the gastrointestinal tract of a subject, which method comprising administering to a subject a direct fed microbial in combination with a protease and a phytase.Type: GrantFiled: January 25, 2019Date of Patent: November 16, 2021Assignee: DuPont Nutrition Biosciences APSInventor: Luis Fernando Romero Millan
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Publication number: 20200318092Abstract: The present invention relates to a method for solubilising arabinoxylan-containing material (particularly insoluble arabinoxylan-containing material), comprising admixing a xylan-containing material with a xylanase comprising a polypeptide sequence shown herein as SEQ ID No. 3, SEQ ID No. 2, SEQ ID No. 1, SEQ ID No. 9, SEQ ID No. 10, SEQ ID No. 11 or SEQ ID No. 15, or a variant, homologue, fragment or derivative thereof having at least 75% identity with SEQ ID No. 3 or SEQ ID No. 2 or SEQ ID No. 1 or SEQ ID No. 9 or SEQ ID No. 10 or SEQ ID No. 11 or SEQ ID No. 15; or a polypeptide sequence which comprises SEQ ID No. 3, SEQ ID No. 2, SEQ ID No. 1, SEQ ID No. 9, SEQ ID No. 10, SEQ ID No. 11 or SEQ ID No. 15 with a conservative substitution of at least one of the amino acids; or a xylanase which is encoded by a nucleotide sequence shown herein as SEQ ID No. 6, SEQ ID No. 5, SEQ ID No. 4, SEQ ID No. 12, SEQ ID No. 13, SEQ ID No. 14, SEQ ID No. 16, SEQ ID No.17 or SEQ ID No.Type: ApplicationFiled: April 3, 2020Publication date: October 8, 2020Inventors: LUIS FERNANDO ROMERO MILLAN, SUSAN ARENT LUND, BRIAN SOEGAARD LAURSEN, ELIJAH G. KIARIE, ZHENGHONG ZHANG, ROSALYN LAU, ZHEYONG YU, FLOOR K KOOY, JAN HENDRIK A VAN TUIJL, BART C KOOPS, MADS BROEGGER PEDERSEN, SOREN DALSGAARD
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Publication number: 20200281225Abstract: Disclosed is feed additive composition consisting essentially of a direct fed microbial comprising one or more bacterial strains in combination with at least one protease and a method for improving the performance of a subject or for improving digestibility of a raw material in a feed, which method comprising administering to a subject a direct fed microbial in combination with a protease.Type: ApplicationFiled: November 4, 2016Publication date: September 10, 2020Inventors: Elijah G. Kiarie, Luis Fernando Romero Millan, Laura Payling, Maria Walsh, Susan Arent Lund
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Publication number: 20200245642Abstract: A method of preparing a feed additive composition comprising: (a) admixing at least one proline tolerant tripeptidyl peptidase predominantly having exopeptidase activity wherein said proline tolerant tripeptidyl peptidase is capable of cleaving tri-peptides from the N-terminus of peptides having (i) (A) Proline at P1; and (B) An amino acid selected from alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, serine, threonine, tryptophan, tyrosine, valine or synthetic amino acids at P1; or (ii) (a?) Proline at PV; and (b?) An amino acid selected from alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, serine, threonine, tryptophan, tyrosine, valine or synthetic amino acids or amines at PV; and one or more ingredients selected from the group consisting of a salt, polyol including sorbitol and glycerol, wheType: ApplicationFiled: January 16, 2020Publication date: August 6, 2020Inventors: SVEND HAANING, KARSTEN MATTHIAS KRAGH, STEPAN SHIPOVSKOV, ANDREI MIASNIKOV, MARIA MA, LUIS FERNANDO ROMERO MILLAN, LUKE BARNARD, SHUKUN YU, ERNST MEINJOHANNS, STEFFEN YDE BAK, PÄIVI NURMINEN, HELI ANGLENIUS
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Patent number: 10695384Abstract: A feed additive composition comprising a direct fed microbial in combination with a protease, a xylanase, an amylase and a phytase, and a method for improving the performance of a subject or for improving digestibility of a raw material in a feed (e.g. nutrient digestibility, such as amino acid digestibility), or for improving nitrogen retention, or for avoiding the negative effects of necrotic enteritis or for improving feed conversion ratio (FCR) or for improving weight gain in a subject or for improving feed efficiency in a subject or for modulating (e.g. improving) the immune response of the subject or for promoting the growth of beneficial bacteria in the gastrointestinal tract of a subject, which method comprising administering to a subject a direct fed microbial in combination with a protease, a xylanase, an amylase and a phytase.Type: GrantFiled: November 6, 2018Date of Patent: June 30, 2020Assignee: DUPONT NUTRITION BIOSCIENCES APSInventors: Luis Fernando Romero Millan, Gregory Ross Siragusa, Mari Ellen Davis, Alexandra Helena Smith
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Patent number: 10612014Abstract: The present invention relates to a method for solubilizing arabinoxylan-containing material (particularly insoluble arabinoxylan-containing material), comprising admixing a xylan-containing material with a xylanase comprising a polypeptide sequence shown herein as SEQ ID No. 3, SEQ ID No. 2, SEQ ID No. 1, SEQ ID No. 9, SEQ ID No. 10, SEQ ID No. 11 or SEQ ID No. 15, or a variant, homolog, fragment or derivative thereof having at least 75% identity with SEQ ID No. 3 or SEQ ID No. 2 or SEQ ID No. 1 or SEQ ID No. 9 or SEQ ID No. 10 or SEQ ID No. 11 or SEQ ID No. 15; or a polypeptide sequence which comprises SEQ ID No. 3, SEQ ID No. 2, SEQ ID No. 1, SEQ ID No. 9, SEQ ID No. 10, SEQ ID No. 11 or SEQ ID No. 15 with a conservative substitution of at least one of the amino acids; or a xylanase which is encoded by a nucleotide sequence shown herein as SEQ ID No. 6, SEQ ID No. 5, SEQ ID No. 4, SEQ ID No. 12, SEQ ID No. 13, SEQ ID No. 14, SEQ ID No. 16, SEQ ID No. 17 or SEQ ID No.Type: GrantFiled: December 15, 2017Date of Patent: April 7, 2020Assignee: DUPONT NUTRITION BIOSCIENCES APSInventors: Luis Fernando Romero Millan, Susan Arent Lund, Brian Soegaard Laursen, Elijah G Kiarie, Zhenghong Zhang, Rosalyn Lau, Zheyong Yu, Floor K Kooy, Jan Hendrik A Van Tuijl, Bart C Koops, Mads Broegger Pedersen, Soeren Dalsgaard
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Publication number: 20190223470Abstract: A feed additive composition comprising a direct fed microbial in combination with a protease, and a phytase, and a method for improving the performance of a subject or for improving digestibility of a raw material in a feed (e.g. nutrient digestibility, such as amino acid digestibility), or for improving nitrogen retention, or for improving the subject's resistance to necrotic enteritis or for improving feed conversion ratio (FCR) or for improving weight gain in a subject or for improving feed efficiency in a subject or for modulating (e.g. improving) the immune response of the subject or for promoting the growth of beneficial bacteria in the gastrointestinal tract of a subject, which method comprising administering to a subject a direct fed microbial in combination with a protease and a phytase.Type: ApplicationFiled: January 25, 2019Publication date: July 25, 2019Inventor: Luis Fernando Romero Millan
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Publication number: 20190090525Abstract: The present invention relates to a method of preparing a corn based product said method comprising contacting a plant composition comprising (consisting of or consisting essentially of) corn or a corn by-product or a combination thereof with a xylanase comprising: i) a polypeptide as set forth in SEQ ID No. 8 or SEQ ID No. 7 or SEQ ID No. 6; or ii) a variant, fragment homologue, fragment or derivative thereof having at least 85% identity with SEQ ID No. 8 or SEQ ID No. 7 or SEQ ID No. 6; or with a xylanase encoded by: a) a nucleotide sequence shown herein as SEQ ID No. 3. SEQ ID No. 2 or SEQ ID No. 1; or b) a nucleotide sequence which can hybridize to the complement of SEQ ID No. 3. SEQ ID No. 2 or SEQ ID No. 1 under high stringency conditions: or c) a nucleotide sequence which has at least 80% identity with SEQ ID No. 3. SEQ ID No. 2 or SEQ ID No. 1. The present invention further relates to the use of the enzyme to produce corn based feedstuffs.Type: ApplicationFiled: October 10, 2018Publication date: March 28, 2019Inventors: Susan Arent Lund, Brian Soegaard Laursen, Elijah G. Kiarie, Luis Fernando Romero Millan, Zhenghong Zhang, Rosalyn Lau, Zheyong Yu, Mads Broegger Pedersen, Soeren Dalsgaard
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Patent number: 10227623Abstract: A process for mechanical destructuring of cellulosic biomass was developed that makes use of a short application of high compression, impact, and shearing forces. The biomass may be destructured using a specific energy input that is less than 40% of the total combustible energy of the biomass. The destructured biomass, with or without saccharification and/or in-feed glycosyl hydrolase enzymes, may be used in feed applications.Type: GrantFiled: November 18, 2014Date of Patent: March 12, 2019Assignee: E I DU PONT DE NEMOURS AND COMPANYInventors: Wathudura Indika Namal De Silva, Paul Joseph Fagan, F Glenn Gallagher, Zheng-Zheng Huang, Guangliang Gary Liu, Aaron Perelman, Luis Fernando Romero Millan, Anton Shpilsky, Daniel A Slanac, Maria Walsh
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Publication number: 20180295858Abstract: A method of preparing a feed additive composition comprising: (a) admixing at least one proline tolerant tripeptidyl peptidase predominantly having exopeptidase activity wherein said proline tolerant tripeptidyl peptidase is capable of cleaving tri-peptides from the N-terminus of peptides having (i) (A) Proline at P1; and (B) An amino acid selected from alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, serine, threonine, tryptophan, tyrosine, valine or synthetic amino acids at P1; or (ii) (a?) Proline at P1?; and (b?) An amino acid selected from alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, serine, threonine, tryptophan, tyrosine, valine or synthetic amino acids or amines at P1?; and one or more ingredients selected from the group consisting of a salt, polyol including sorbitol and glycerol, wType: ApplicationFiled: October 23, 2015Publication date: October 18, 2018Inventors: Svend Haaning, Karsten Matthias Kragh, Stepan Shipovskov, Andrei Miasnikov, Maria Ma, Luis Fernando Romero Millan, Luke Barnard, Shukun Yu, Ernst Meinjohanns, Steffen Bak, Päivi Nurminen, Heli Putaala
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Patent number: 10058110Abstract: The disclosure relates to enzyme producing Bacillus strains that provide benefits to animals and methods of using these strains. In one embodiment, the disclosure relates compositions comprising the enzyme producing Bacillus strains. In yet another embodiment, the disclosure relates to a feed for an animal comprising enzyme producing Bacillus strains.Type: GrantFiled: February 10, 2015Date of Patent: August 28, 2018Assignee: DUPONT NUTRITION BIOSCIENCES APSInventors: Mari Ellen Davis, Justin Sawall, Anthony Neumann, Gregory Ross Siragusa, Luis Fernando Romero Millan
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Publication number: 20180094253Abstract: The present invention relates to a method for solubilising arabinoxylan-containing material (particularly insoluble arabinoxylan-containing material), comprising admixing a xylan-containing material with a xylanase comprising a polypeptide sequence shown herein as SEQ ID No. 3, SEQ ID No. 2, SEQ ID No. 1, SEQ ID No. 9, SEQ ID No. 10, SEQ ID No. 11 or SEQ ID No. 15, or a variant, homologue, fragment or derivative thereof having at least 75% identity with SEQ ID No. 3 or SEQ ID No. 2 or SEQ ID No. 1 or SEQ ID No. 9 or SEQ ID No. 10 or SEQ ID No. 11 or SEQ ID No. 15; or a polypeptide sequence which comprises SEQ ID No. 3. SEQ ID No. 2, SEQ ID No. 1, SEQ ID No. 9, SEQ ID No. 10, SEQ ID No. 11 or SEQ ID No. 15 with a conservative substitution of at least one of the amino acids; or a xylanase which is encoded by a nucleotide sequence shown herein as SEQ ID No. 6, SEQ ID No. 5, SEQ ID No. 4, SEQ ID No. 12, SEQ ID No. 13, SEQ ID No. 14, SEQ ID No. 16, SEQ ID No. 17 or SEQ ID No.Type: ApplicationFiled: December 15, 2017Publication date: April 5, 2018Inventors: LUIS FERNANDO ROMERO MILLAN, SUSAN ARENT LUND, BRIAN SOEGAARD LAURSEN, ELIJAH G. KIARIE, ZHENGHONG ZHANG, ROSALYN LAU, ZHEYONG YU, FLOOR K KOOY, JAN HENDRIK A VAN TUIJL, BART C KOOPS, MADS BROEGGER PEDERSEN, SOEREN DALSGAARD
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Publication number: 20150351433Abstract: The present invention provides a xylanase comprising amino acid sequence as set forth in SEQ ID No.1, SEQ ID No.2 or SEQ ID No.8, and a nucleotide sequence encoding said xylanase shown as SEQ ID No.3, SEQ ID No.4 or SEQ ID No.5. The present invention also provides a method of preparing a corn based product comprising contacting a plant composition comprising corn or a corn by-product or a combination thereof with said xylanase.Type: ApplicationFiled: August 3, 2012Publication date: December 10, 2015Applicant: DUPONT NUTRITION BIOSCIENCES APSInventors: Susan Lund Arent, Brian Sogaard Laursen, Elijah Gituanjah Kiarie, Luis Fernando Romero Millan, Zhenghong Zhang, Rosalyn Lau, Zheyong Yu, Soren Dalsgaard
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Publication number: 20150216203Abstract: A feed additive composition comprising a direct fed microbial (DFM), in combination with a xylanase (e.g. endo-1,4-?-d-xylanase) and a ?-glucanase (and optionally a further fibre degrading enzyme), wherein the DFM is selected from the group consisting of an enzyme producing strain; a C5 sugar-fermenting strain; a short-chain fatty acid-producing strain; a fibrolytic, endogenous microflora-promoting strain; or combinations thereof. The DFM may be selected from the group consisting of: Bacillus subtilis AGTP BS3BP5, Bacillus subtilis AGTP BS442, B. subtilis AGTP BS521, B. subtilis AGTP BS918, Bacillus subtilis AGTP BS1013, B. subtilis AGTP BS1069, B. subtilis AGTP 944, B. pumilus AGTP BS 1068 or B.Type: ApplicationFiled: August 2, 2013Publication date: August 6, 2015Applicant: DUPONT NUTRITIONAL BIOSCIENCES APSInventors: Mai Faurschou Isaksen, Marion Bernardeau, Luis Fernando Romero Millan, Elijah Gituanjah Kiarie, Susan Lund Arent, Piiivi Helena Nurminen, Sofia Forssten, Daniel Petri, Elizabeth Ann Galbraith
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Publication number: 20150210993Abstract: The present invention relates to a method for solubilising arabinoxylan-containing material (particularly insoluble arabinoxylan-containing material), comprising admixing a xylan-containing material with a xylanase comprising a polypeptide sequence shown herein as SEQ ID No. 3, SEQ ID No. 2, SEQ ID No. 1, SEQ ID No. 9, SEQ ID No. 10, SEQ ID No. 11 or SEQ ID No. 15, or a variant, homologue, fragment or derivative thereof having at least 75% identity with SEQ ID No. 3 or SEQ ID No. 2 or SEQ ID No. 1 or SEQ ID No. 9 or SEQ ID No. 10 or SEQ ID No. 11 or SEQ ID No. 15; or a polypeptide sequence which comprises SEQ ID No. 3, SEQ ID No. 2, SEQ ID No. 1, SEQ ID No. 9, SEQ ID No. 10, SEQ ID No. 11 or SEQ ID No. 15 with a conservative substitution of at least one of the amino acids; or a xylanase which is encoded by a nucleotide sequence shown herein as SEQ ID No. 6, SEQ ID No. 5, SEQ ID No. 4, SEQ ID No. 12, SEQ ID No. 13, SEQ ID No. 14, SEQ ID No. 16, SEQ ID No. 17 or SEQ ID No.Type: ApplicationFiled: August 2, 2013Publication date: July 30, 2015Applicant: DUPONT NUTRITION BIOSCIENCES APSInventors: Susan Lund Arent, Brian Sogaard Laursen, Elijah Gituanjah Kiarie, Luis Fernando Romero Millan, Zhenghong Zhang, Rosalyn Lau, Zheyong Yu, Floor Klaaske Kooy, Jan Hendrik Van Tuijl, Bart Christiaan Koops, Mads Brogger Pedersen, Soren Dalsgaard