Abstract: The use of tocotrienols in medicine, veterinary or cosmetics, namely through the stabilization of tocotrienols, in particular in cosmetic formulations without hampering its functions in the skin is provided. In particular, the modification of tocotrienols with nicotinic acid results in the stabilization of the molecule and the penetration profile in human skin. The compounds and composition of are useful in medicine, veterinary or cosmetic industry namely in the prevention, therapy or treatment of skin diseases, skin disorders, or as a therapy or treatment of acne, seborrheic dermatitis or as an anti-aging agent.

Abstract: A computer-implemented control method of constrained controlling of a computer-controlled system. The system is controlled according to a control input, which is safe if a constraint quantity resulting from the controlling of the computer-controlled system exceeds a constraint threshold. A current control input is determined based on previous control inputs and corresponding previous noisy measurements. The computer-controlled system is controlled according to the current control input, thereby obtaining a current noisy measurement of the resulting constraint quantity. The current control input is determined based on a mutual information between a first random variable representing the constraint quantity resulting from the current control input and a second random variable indicating whether a further control input is safe.

Abstract: The present disclosure relates to an ostomy device for manually controlling the release and collection of bodily waste from an external stoma of a subject. The ostomy device includes a collapsible collecting bag; a first base plate for encircling the stoma; a second base plate having an opening and connected to the collecting bag such that bodily waste can flow through the first base plate and the opening of the second base plate into the collecting bag; a valve for releasing intra-abdominal gas into an exterior of the device; and a cap for closing and for opening the device comprising an inward side for closing onto the second base plate. The valve comprises a valve member for closing the valve, which is openable by pressure applied in a direction towards the subject skin. The present disclosure also relates to an ostomy system including the aforesaid medical device.

Abstract: The use of tocotrienols in medicine, veterinary or cosmetics, namely through the stabilization of tocotrienols, in particular in cosmetic formulations without hampering its functions in the skin is provided. In particular, the modification of tocotrienols with nicotinic acid results in the stabilization of the molecule and the penetration profile in human skin. The compounds and composition of are useful in medicine, veterinary or cosmetic industry namely in the prevention, therapy or treatment of skin diseases, skin disorders, or as a therapy or treatment of acne, seborrheic dermatitis or as an anti-aging agent.

Abstract: An implantable ureteral stent for implanting in the ureter comprising a first end for placing in the renal pelvis and a second end for placing in the bladder, each said end including a pressure sensor arranged to measure urinary pressure. Each pressure sensor can include an electronic circuit with electronic components and a substrate for receiving the electronic circuit and electronic components, wherein said substrate is a flexible membrane. The flexible membrane can be a sleeve surrounding the stent or the flexible membrane can be a flexible tube that is part of a thin tube that forms the stent, in particular the flexible membrane may have a thickness of 80-150 ?m. The electronic components can be connected by wire-bonding. Each pressure sensor can have a flexible PCB having soldered electronic components. A manufacturing method is disclosed to make said implantable ureteral stent.

Abstract: An implantable biliary or pancreatic stent for implanting in the gastrointestinal tract having a first end for placing in the bile duct or the pancreatic duct and a second end for placing in the duodenum, the first end including a pressure sensor arranged to measure bile duct or pancreatic duct pressure, respectively, and the second end including a pressure sensor arranged to measure duodenal pressure. Each pressure sensor can include an electronic circuit with electronic components and a substrate for receiving the electronic circuit and electronic components, wherein said substrate is a flexible membrane. The flexible membrane can be a sleeve surrounding the stent, or the flexible membrane can be a flexible tube that is part of a thin tube that forms the stent, in particular the flexible membrane can have a thickness of 80-150 ?m. A manufacturing method is disclosed for providing said implantable biliary or pancreatic stent.

Abstract: The present disclosure relates to a hydrogel fibre comprising an ionic hydrogel and a second component in a plurality of compartments, wherein the second component is selected from a second hydrogel, a hydrophilic solution, or a mixture thereof. It is also disclosed the method to obtain the aforesaid hydrogel fibres. This disclosure also relates to a composition comprising the hydrogel fibres and a suitable carrier, and an article/kit, a bundle, a mesh or a membrane comprising the hydrogel fibre. A composition comprising an ionic hydrogel and a second component for use in medicine administered in a hydrogel fibre comprising a plurality of compartments is also disclosed.

Abstract: The present disclosure relates to a composition for the use in the fields of cancer, immunotherapy and biotechnology. Particularly it relates to the field of gellan gum hydrogel-like particles for artificial antigen presentation in immunotherapy.

Abstract: The present disclosure relates to enzymatic and redox responsive polymeric micelle, its method of production as well as its uses. Specifically, use of the enzymatic- and redox-responsive polymeric micelle for drug delivery.

Abstract: A captured image contains a region of interest (ROI) including a plurality of characters to be recognized as text, and non-ROI content to be excluded from the OCR. The captured image is preprocessed to detect and locate the ROI in the captured image, and to determine a boundary of the ROI, including transforming the captured image to a first feature descriptor representation (FDR), and performing a comparison between the first FDR and at least one ROI template that includes at least a second FDR of a representative ROI image. The preprocessing produces an output to be provided to an OCR engine to perform autonomous OCR processing of the ROI while ignoring the non-ROI content based on the determined boundary of the ROI.

Abstract: The present invention relates to a computer implemented method for providing in advance information on driving actions for improving the global efficiency of a vehicle. The method comprising the steps of receiving vehicle technical data (VTD) from a VTD processor at a processing device; generating local information at the processing device from the received VTD and processing device information generated by the processing device; creating remote information at a remote server from the processing device information, external data provider information coming from one or more external data providers and client logistic information; and presenting the remote information and optionally the local information to the driving agent in advance of the driving action using the processing device. A system for carrying out said method comprising at least one processing device connected to a remote server is also disclosed.

Abstract: The present disclosure relates to a silk-fibroin ink suitable for 3D printing. The ink for 3D printing now disclosed may be used in chemical and pharma industries, medicine, engineering, manufacturing namely for the production of capsules, fibres, membranes, particles, scaffolds, medical devices, microfluidic devices and patient-specific implants.

Abstract: The present disclosure describes a eutectic composition for use in the treatment of cancer comprising a nonsteroidal anti-inflammatory drug and a terpene, preferably ibuprofen and limonene.

Abstract: One general aspect includes a system to translate language exhibited on a publicly viewable sign, the system including: a memory configured to include one or more executable instructions and a processor configured to execute the executable instructions, where the executable instructions enable the processor to carry out the steps of: reviewing the sign; translating relevant information conveyed on the sign from a first language to a second language; and producing an output in an interior of a vehicle, the output based on the second language of the relevant information.

Abstract: The present disclosure relates to a hydrogel comprising: hyaluronic acid, and liposomes physically crosslinked to hyaluronic acid, wherein said hydrogel encapsulates a cell type or a plurality of cell types. The hydrogel of the present disclosure shows a positive therapeutic effect in the treatment or therapy of multiple sclerosis. A pharmaceutical composition comprising a therapeutically effective amount of a hydrogel and a pharmaceutically acceptable excipient/carrier are also disclosed.

Abstract: The present application relates to a method and apparatus for determining a preferred off-road vehicle path including a lidar operative to generate a depth map of an off road surface, a camera for capturing an image of the off road surface, a processor operative to receive the depth map, determine a vehicle path in response to the depth map and a host vehicle characteristic, combine a graphical representation of the vehicle path with the image to generate an augmented image, and a display to display the augmented image to a host vehicle operator.

Abstract: The present disclosure relates to a composition for the release of the bioactive substance comprising: sucrose acetate isobutyrate dissolved in an ionic liquid and an additive selected from the list consisting of: chitin, silk fibroin, cellulose, alginate, chitosan, gellan gum, dextrin, collagen, guar gum, carregeenan, heparin, kefiran, or mixtures thereof. By taking advantage of the properties of an ionic liquid (IL), in particular 1-butyl-imidazolium acetate (BMIMAc), it was possible to achieve a good dissolution of SAIB, which combined with chitin and/or silk, natural polymers, allows the development of the structures with different shape and sizes.

Abstract: A system comprises fuel consumption prediction circuitry and user interface circuitry. The fuel consumption prediction circuitry is operable to receive trip constraints for a trip to be made by a vehicle, and vehicle information for the vehicle. The fuel consumption prediction circuitry is operable to generate, based on the trip constraints and the vehicle information, a first trip option having a first predicted travel time and a first predicted fuel consumption, and a second trip option having a second predicted travel time and a second predicted fuel consumption. The fuel consumption prediction circuitry is operable to communicate the first trip option and the second trip option to user interface circuitry. The user interface circuitry is operable to receive the first trip option and the second trip option and present the options to a user.

Abstract: The present invention relates to a computer implemented method for providing in advance information on driving actions for improving the global efficiency of a vehicle. The method comprising the steps of receiving vehicle technical data (VTD) from a VTD processor at a processing device; generating local information at the processing device from the received VTD and processing device information generated by the processing device; creating remote information at a remote server from the processing device information, external data provider information coming from one or more external data providers and client logistic information; and presenting the remote information and optionally the local information to the driving agent in advance of the driving action using the processing device. A system for carrying out said method comprising at least one processing device connected to a remote server is also disclosed.

Abstract: Stents and methods for producing stents are provided. The stent includes a polymeric substrate comprised of 10-50% (w/w) of alginate and 45-85% (w/w) of gelatine and further includes a polymeric biodegradable resin for coating said polymeric substrate. The stent can also include a contrast agent. The stent can further include a crosslinking agent. The method for producing the stent includes dissolving the alginate and gelatine in water and stirring to obtain a polymeric substrate. The method also includes adding a crosslinking agent to the substrate, injecting the substrate into a mold to obtain the stent, placing the stent in a first alcohol solution, and placing the stent in a crosslinking agent solution. The method further includes placing the stent in a second alcohol solution, and a series of interchanging drying and immersing steps.