Abstract: Compositions and methods for early diagnosis, risk stratification, and effective management and treatment of patients with hepatocellular carcinoma are provided. The compositions and methods selectively target S100A10, for effective detection of S100A10 in a subject, for example, from plasma samples or from tissue biopsy, and for effective inhibiting and/or reducing the activities and/or quantities of S100A10 in vitro and/or in vivo. Methods for selecting patients who would be amenable for the disclosed therapies and for treating such patients are also described.

Abstract: The subject invention pertains to antibodies that target LANCL1. The anti-LANCL1 antibodies can be used in methods of treating cancer, including hepatocellular carcinoma. The anti-LANCL1 antibody can be used as a therapeutic regimen for treatment or as part of a combination treatment. Further, the anti-LANCL1 antibodies may also be useful for targeting the tumor initiating cells.

Abstract: A wearable device for healthcare and a method thereof, wherein the device is worn on a finger for measuring the health data of the user, including but not limited to, the heart rate, blood oxygen saturation, etc. The wearing size of the device is adjustable for different sizes of fingers. In one embodiment, the device includes a main body at least partially worn on a digit of a user; at least one physiological sensor attached to the main body for detecting physiological information; and at least two branches coupled to the main body for holding the digit while reducing the movement of the device. At least a part of at least one branch is changeable such that the wearing size of the device is adjustable for different sizes of digits. In another embodiment, at least a part of at least one branch is movable such that the wearing size of the device is adjustable for different sizes of digits.

Abstract: A testing device and method thereof verifies performance of a non-invasive physiological information detecting device. The testing device incorporates a first layer to modulate one or more electromagnetic signals, e.g., light, emitted from the non-invasive physiological information detecting device in a first predetermined manner and a second layer to process the electromagnetic signal from the first layer such that the modulated signal received at the physiological information detecting device simulates a change in the electromagnetic signal during a real detecting process. In one embodiment, the second layer modulates one or more electromagnetic signals from the first layer in a second predetermined manner, wherein at least one of the first and second layers modulates one kind of the electromagnetic signals.

Abstract: A wearable device for healthcare and a method thereof, wherein the device is worn on a finger for measuring the health data of the user, including but not limited to, the heart rate, blood oxygen saturation, etc. The wearing size of the device is adjustable for different sizes of fingers. In one embodiment, the device includes a main body at least partially worn on a digit of a user; at least one physiological sensor attached to the main body for detecting physiological information; and at least two branches coupled to the main body for holding the digit while reducing the movement of the device. At least a part of at least one branch is changeable such that the wearing size of the device is adjustable for different sizes of digits. In another embodiment, at least a part of at least one branch is movable such that the wearing size of the device is adjustable for different sizes of digits.

Abstract: A testing device and method thereof verifies performance of a non-invasive physiological information detecting device. The testing device incorporates a first layer to modulate one or more electromagnetic signals, e.g., light, emitted from the non-invasive physiological information detecting device in a first predetermined manner and a second layer to process the electromagnetic signal from the first layer such that the modulated signal received at the physiological information detecting device simulates a change in the electromagnetic signal during a real detecting process. In one embodiment, the second layer modulates one or more electromagnetic signals from the first layer in a second predetermined manner, wherein at least one of the first and second layers modulates one kind of the electromagnetic signals.

Abstract: An electronic device measures physiological information of a living subject. The electronic device includes a sensor assembly, a first driving unit with an electromagnetic structure and a second driving unit. The first driving unit drives the sensor assembly to scan the living subject's skin along a scan path in a non-contact way to determine a measuring position. The second driving unit drives the sensor assembly to move towards and contact the living subject's skin to measure the physiological information based on the measuring position. In a typical embodiment, the sensor is configured under a measurement surface where a wrist of a user is put on. The sensor scans the user's wrist along a scan path under the wrist in a non-contact way and move upwards to contact the user's wrist for measuring the physiological information based on the scanning result.

Abstract: A compact device useful for measuring an absorption spectrum of a liquid, such as water with organic contaminants, is provided. The device comprises an array of light emitting diodes (LEDs) each emitting light with a unique spectral peak. A reflector shaped as a half ellipsoid reflects the emitted light to form a reference beam. The reflector has an opening to allow part of the emitted light to form a measurement beam after passing through the liquid. Two photodetectors measure the reference beam and the measurement beam to give a reference intensity and a measured intensity, respectively. The LEDs sequentially emit showers of light one-by-one, giving plural pairs of reference and measured intensities for estimating the absorption spectrum. The device receives energy from a separate power-providing device through wireless power transfer. The power-providing device harvests motional energy of the flowing liquid to generate electrical energy.

Abstract: A compact device useful for measuring an absorption spectrum of a liquid, such as water with organic contaminants, is provided. The device comprises an array of light emitting diodes (LEDs) each emitting light with a unique spectral peak. A reflector shaped as a half ellipsoid reflects the emitted light to form a reference beam. The reflector has an opening to allow part of the emitted light to form a measurement beam after passing through the liquid. Two photodetectors measure the reference beam and the measurement beam to give a reference intensity and a measured intensity, respectively. The LEDs sequentially emit showers of light one-by-one, giving plural pairs of reference and measured intensities for estimating the absorption spectrum. The device receives energy from a separate power-providing device through wireless power transfer. The power-providing device harvests motional energy of the flowing liquid to generate electrical energy.

Abstract: The subject matter disclosed herein relates to an optical emitter-detector for physiological measurements.

Abstract: An electronic health record storage device is provided. The device is configured for operation in conjunction with a host device to generate and store health record data about a user. According to one embodiment, the system comprises memory including executable instructions stored in the memory, the executable instructions including an autorun file and operating instructions; one or more sensors configured for engagement by the user; an interface configured for interfacing with a host device; and a controller in operable communication with the memory, the one or more sensors, and the interface, and wherein the controller is configured to execute the executable instructions stored in the memory, the controller further configured to receive power from the host device, retrieve data from the host device, receive health data from the one or more sensors, generate a health record comprising timing data and health data, and store the health record in the memory.