Patents by Inventor Luis Serrano Pubul

Luis Serrano Pubul has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Computer-Implemented Means and Methods for the Prediction of the Stability of Proteins and Protein Complexes
    Publication number: 20260196294
    Abstract: The present methods and systems generally relate to the biomedical field and relate to subfields of computational biology and bioinformatics. More, specifically the invention provides an artificial intelligence algorithm which can predict the stability of proteins and protein complexes.
    Type: Application
    Filed: November 28, 2023
    Publication date: July 9, 2026
    Inventors: Frederic Rousseau, Joost Schymkowitz, Gabriele Orlando, Luis Serrano Pubul
  • Genetically Modified Mycoplasma Bacteria Active Against Heterogenous Bacterial Biofilms
    Publication number: 20240382537
    Abstract: The present invention concerns genetically modified Mycoplasma bacteria that express gene products having an anti-biofilm activity against a biofilm formed by multiple bacteria such as Pseudomonas aeruginosa and Staphylococcus aureus. Further intended are pharmaceutical compositions comprising genetically modified Mycoplasma bacteria and their use as a medicament.
    Type: Application
    Filed: September 20, 2022
    Publication date: November 21, 2024
    Inventors: Rocco Mazzolini, Maria Lluch Senar, Claudio Joao Ribeiro Dos Santos, Luis Serrano Pubul
  • Tools and Methods for Mycoplasma Engineering
    Publication number: 20240287500
    Abstract: The present invention concerns oligonucleotide modification systems to enable efficient genome engineering in Mycoplasma bacteria. Also intended is the use of these systems in Mycoplasma engineering, and methods comprising administering the oligonucleotide modification systems to Mycoplasma to generate genetically engineered Mycoplasma strains not naturally occurring.
    Type: Application
    Filed: January 29, 2021
    Publication date: August 29, 2024
    Inventors: Carlos Piñero Lambea, Maria Lluch Senar, Luis Serrano Pubul
  • Attenuated Mycoplasma Bacteria
    Publication number: 20230310564
    Abstract: The present invention concerns genetically modified Mycoplasma bacteria. Also intended are methods of generating attenuated Mycoplasma bacteria and their use to produce heterologous gene products. Further intended are pharmaceutical compositions comprising the attenuated Mycoplasma bacteria described herein.
    Type: Application
    Filed: March 19, 2021
    Publication date: October 5, 2023
    Inventors: Carlos Piñero Lambea, Maria Lluch Senar, Luis Serrano Pubul
  • Peptides and uses thereof
    Patent number: 10745450
    Abstract: The invention provides a series of peptide signals which, when linked to a polypeptide of interest (POI), ensure that said polypeptide is secreted in high yields by a host cell such as Mycoplasma pneumoniae. The invention also provides fusion proteins tagged with said peptide signals, the nucleic acid sequences coding for them, host cells comprising said tagged fusion proteins and a variety of uses of the fusion proteins and the host cells.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: August 18, 2020
    Assignees: FUNDACIÓ CENTRE DE REGULACIÓ GENÓMICA (CRG), INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS
    Inventors: Bernhard Paetzold, Maria Lluch Senar, Luis Serrano Pubul
  • PEPTIDES AND USES THEREOF
    Publication number: 20180037613
    Abstract: The invention provides a series of peptide signals which, when linked to a polypeptide of interest (POI), ensure that said polypeptide is secreted in high yields by a host cell such as Mycoplasma pneumoniae. The invention also provides fusion proteins tagged with said peptide signals, the nucleic acid sequences coding for them, host cells comprising said tagged fusion proteins and a variety of uses of the fusion proteins and the host cells.
    Type: Application
    Filed: February 26, 2016
    Publication date: February 8, 2018
    Inventors: Bernhard PAETZOLD, Maria LLUCH SENAR, Luis SERRANO PUBUL
  • VARIANTS OF THE TNF SUPERFAMILY AND USES THEREOF
    Publication number: 20140178329
    Abstract: Described are novel variants of APRIL that modulate signaling via receptor-specific agonist activity, and nucleic acids encoding these variant proteins. Further described is the use of these novel proteins in the treatment of APRIL-associated disorders, in particular, pathologies of the immune system and oncological disorders.
    Type: Application
    Filed: December 13, 2013
    Publication date: June 26, 2014
    Applicants: Institucio Catalana de Recerca I Estudis Avancats (ICREA), Fundacio Privada Centre de Regulacio Genomica (CRG)
    Inventors: Luis Serrano Pubul, Albert Martinus Van Der Sloot, Jan Paul Medema, Fiona Clare Kimberley