Patents by Inventor Luis Sobral

Luis Sobral has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the Esterification of a Carbothioic Acid
    Publication number: 20070287846
    Abstract: A process for preparing compounds of formula [II] by esterification of the C-17 hydroxyl group of 6?,9?-difluoro-11?,17?-dihydroxy-16?-methyl-3-oxoandrosta-1,4-diene-17?-carbothioic acid, the compound of formula [I] comprises treating compound [I] with a slight excess of an acyl chloride of general formula R—COCl, where R represents —CH2CH3, —CH2CH2CH3 or —CH(CH3)2, in an inert solvent, in the presence of a tertiary amine. Preferably the process is carried out using pyridine in the presence of acetone at a temperature of from 5° C. to ?20° C.
    Type: Application
    Filed: December 2, 2004
    Publication date: December 13, 2007
    Inventors: Luis Sobral, Dionisio Martin, William Heggie, Emilia Leitao
  • Process for the purification of roxithromycin
    Patent number: 6204368
    Abstract: A process for the purification of roxithromycin, an antibiotic for therapeutic purposes, in which the purification is carried out by the dissolution or suspension of the product in methanol followed by cooling. Purification may also be obtained by addition of a non-solvent and/or by concentration of the mixture, thus obtaining a purified product.
    Type: Grant
    Filed: August 11, 1999
    Date of Patent: March 20, 2001
    Assignee: Hovione Inter Ltd.
    Inventors: William Heggie, Alexandre Carvalho, Luis Sobral