Patents by Inventor Luis Tecedor

Luis Tecedor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT OF LYSOSOMAL STORAGE DISEASE IN THE EYE THROUGH ADMINISTRATION OF AAVS EXPRESSING TPP1
    Publication number: 20200360491
    Abstract: Provided are methods of treating the retinal dysfunction in a mammal with lysosomal storage disorder which method comprises sub-retinal administration of recombinant AAV particles encoding a soluble lysosomal tripeptidyl peptidase 1 (TPP1). In particular, the retinal dysfunction may be occurring in children with CLN2 deficiency receiving enzyme replacement therapy or gene therapy for their disease.
    Type: Application
    Filed: April 8, 2020
    Publication date: November 19, 2020
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Beverly DAVIDSON, Luis TECEDOR
  • METHODS AND COMPOSITIONS FOR TREATING BRAIN DISEASES
    Publication number: 20200009267
    Abstract: The present disclosure provides methods of treating a disease or delivering a therapeutic agent to a mammal comprising administering to the mammal's cisterna magna and/or ventricle an rAAV particle containing a vector comprising a nucleic acid encoding a therapeutic protein inserted between a pair of AAV inverted terminal repeats in a manner such that cells with access to the cerebrospinal fluid (CSF) express the therapeutic agent and in certain embodiments secretes the therapeutic agent into the CSF for distribution to the brain.
    Type: Application
    Filed: June 28, 2019
    Publication date: January 9, 2020
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Beverly L. Davidson, Luis Tecedor, Young Hong Chen
  • GENE TRANSFER COMPOSITIONS, METHODS AND USES FOR TREATING NEURODEGENERATIVE DISEASES
    Publication number: 20190269797
    Abstract: Provided are methods of treating a lysosomal storage disorder in a mammal which method includes administering AAV particles encoding a polypeptide to the central nervous system of the mammal. AAV particles may be delivered by direct injection into the brain, spinal cord, cerebral spinal fluid or a portion thereof for expression.
    Type: Application
    Filed: November 3, 2017
    Publication date: September 5, 2019
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Beverly L. DAVIDSON, Yong Hong CHEN, Luis TECEDOR
  • Methods and compositions for treating brain diseases
    Patent number: 10391184
    Abstract: The present disclosure provides methods of treating a disease or delivering a therapeutic agent to a mammal comprising administering to the mammal's cisterna magna and/or ventricle an rAAV particle containing a vector comprising a nucleic acid encoding a therapeutic protein inserted between a pair of AAV inverted terminal repeats in a manner such that cells with access to the cerebrospinal fluid (CSF) express the therapeutic agent and in certain embodiments secretes the therapeutic agent into the CSF for distribution to the brain.
    Type: Grant
    Filed: July 20, 2014
    Date of Patent: August 27, 2019
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Luis Tecedor, Yong Hong Chen
  • METHODS FOR TREATING NEURODEGENERATIVE DISEASES USING GENE THERAPY TO DELAY DISEASE ONSET AND PROGRESSION WHILE PROVIDING COGNITIVE PROTECTION
    Publication number: 20180236105
    Abstract: The present disclosure provides methods of treating a lysosomal storage disorder in a mammal which method comprises administering AAV particles encoding a polypeptide directly to the central nervous system of the mammal in conjunction with administering at least two immunosuppressive agents. AAV particles may be delivered by direct injection into the brain, spinal cord, cerebral spinal fluid or a portion thereof.
    Type: Application
    Filed: October 24, 2016
    Publication date: August 23, 2018
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Beverly L. Davidson, Yong Hong Chen, Luis Tecedor
  • METHODS AND COMPOSITIONS FOR TREATING BRAIN DISEASES
    Publication number: 20160166709
    Abstract: The present disclosure provides methods of treating a disease or delivering a therapeutic agent to a mammal comprising administering to the mammal's cisterna magna and/or ventricle an rAAV particle containing a vector comprising a nucleic acid encoding a therapeutic protein inserted between a pair of AAV inverted terminal repeats in a manner such that cells with access to the cerebrospinal fluid (CSF) express the therapeutic agent and in certain embodiments secretes the therapeutic agent into the CSF for distribution to the brain.
    Type: Application
    Filed: July 20, 2014
    Publication date: June 16, 2016
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Beverly L. Davidson, Luis Tecedor, Yong Hong Chen
  • THERAPEUTIC METHODS
    Publication number: 20160038521
    Abstract: Certain embodiments of the present invention provide a method for treating or preventing juvenile neuronal ceroid lipofuscinosis (JNCL) in an animal comprising administering CBX, GRA, or GZA to the animal.
    Type: Application
    Filed: March 17, 2014
    Publication date: February 11, 2016
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Beverly L. Davidson, Colleen S. Stein, Mark Schultz, Luis Tecedor, Tammy L. Kielian