Abstract: The present invention is directed to substituted certain 1-pyrazolyl, 5-, 6-disubstituted indazole derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, and ring A are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.

Abstract: A device for learning or teaching computer programming and, more specifically, the steps of executing consecutive computer source lines. The device includes an enclosure containing a source code panel having printed lines of source code visible through a first window in the enclosure and a see-through coding line bar movable across the source code panel to draw the user's attention to each consecutive line of source code being examined. A user-operable control is mounted in the device and is connected to the coding line bar such that movement of the user-operable control mechanically moves the coding line bar across the source code panel to sequentially highlight each consecutive line of code. A comment member and/or a console panel displaying comments and/or output relative to the specific line of code being examined may be movably mounted within the enclosure and be visible through a respective window in the enclosure.

Abstract: The present invention is directed to certain 2-aminoquinzaoline derivatives of Formula (I): Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, and R3 are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

Abstract: Aspects of the disclosure relate to methods for controlling a vehicle having an autonomous driving mode. For instance, sensor data may be received from one or more sensors of the perception system of the vehicle, the sensor data identifying characteristics of an object perceived by the perception system. When it is determined that the object is no longer being perceived by the one or more sensors of the perception system, predicted characteristics for the object may be generated based on one or more of the identified characteristics. The predicted characteristics of the object may be used to control the vehicle in the autonomous driving mode such that the vehicle is able to respond to the object when it is determined that the object is no longer being perceived by the one or more sensors of the perception system.

Abstract: The present invention is an improvement on the spinning top that includes a plurality of radial indentations, notches, or holes along the outer circumference. It also includes a sloped, geometrically shaped stem, topped with a rounded gear used to spin the top. A plurality of square-holed inserts which lock in place when inserted over the sloped, square stem, are also provided for demonstrating STEM concepts. The indentations, when spinning, highlight the effect of AC electric light by creating a strobing effect that appears at first to move with the rotation of the top, then appears to stand still, and then reverses rotation. The interchangeable parts or spokes make it possible for the invention to have variable geometry that allows the invention's mass, balance, and weight distribution to be modified. The invention's indentations, interchangeable spokes, and graphical locking inserts can be used individually or in unison to demonstrate and teach various STEM concepts.

Abstract: A clip installation tool that includes a shaft defining a first bore centered around a central axis. The first bore receives a spring therein. The clip installation tool further includes a movable portion partially disposed within the first bore and in contact with the spring. The movable portion defines a second bore. The clip installation tool further includes a stopper extending at least partially within the second bore and a handle coupled to the shaft.

Abstract: Aspects of the disclosure relate to methods for controlling a vehicle having an autonomous driving mode. For instance, sensor data may be received from one or more sensors of the perception system of the vehicle, the sensor data identifying characteristics of an object perceived by the perception system. When it is determined that the object is no longer being perceived by the one or more sensors of the perception system, predicted characteristics for the object may be generated based on one or more of the identified characteristics. The predicted characteristics of the object may be used to control the vehicle in the autonomous driving mode such that the vehicle is able to respond to the object when it is determined that the object is no longer being perceived by the one or more sensors of the perception system.

Abstract: The present invention is directed to substituted certain N-heteroaryl indazole derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, X, Y, and Z are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.

Abstract: Some embodiments relate to a first electronic network node is provided (110) configured for a cryptographic operation. The first network node is configured to receive as input a difficulty parameter (d), and a structure parameter (n), and to obtain a shared matrix (A), the shared matrix being shared a second network node through a communication interface, entries in the shared matrix A being selected modulo a first modulus (q), the shared matrix (A) being a square matrix (k×k) of dimension (k) equal to the difficulty parameter (d) divided by the structure parameter (n), the entries in the shared matrix (A) being polynomials modulo a reduction polynomial (ƒ) of degree equal to the structure parameter (n), said cryptographic operation using the shared matrix.

Abstract: The present invention provides for a first PHY including an SGMII Ethernet host interface and a second PHY including a Single Pair Ethernet (SPE) protocol and the module provides for migration of standard SGMII host interface Ethernet to SPE protocol wherein communication over single twisted pair on a line side interface of the module is provided

Abstract: A clip installation tool that includes a shaft defining a first bore centered around a central axis. The first bore receives a spring therein. The clip installation tool further includes a movable portion partially disposed within the first bore and in contact with the spring. The movable portion defines a second bore. The clip installation tool further includes a stopper extending at least partially within the second bore and a handle coupled to the shaft.

Abstract: Aspects of the disclosure provide systems and methods for confirming the identity of a passenger and changing destination of a vehicle. This may include receiving dispatching instructions to pick up a first passenger at a pickup location and to drop off the first passenger at a first destination as well as authentication information for authenticating a first client computing device of the first passenger. Once the client device is authenticated and a second passenger enters the vehicle, the vehicle is maneuvered towards the first destination. While doing so, a location of the vehicle is compared to location information received from the client computing devices. A notification is sent to a dispatching server based on the comparison and a second destination location is received in response. The vehicle is then maneuvered towards the second destination instead of the first destination.

Abstract: Aspects of the disclosure relate to methods for controlling a vehicle having an autonomous driving mode. For instance, sensor data may be received from one or more sensors of the perception system of the vehicle, the sensor data identifying characteristics of an object perceived by the perception system. When it is determined that the object is no longer being perceived by the one or more sensors of the perception system, predicted characteristics for the object may be generated based on one or more of the identified characteristics. The predicted characteristics of the object may be used to control the vehicle in the autonomous driving mode such that the vehicle is able to respond to the object when it is determined that the object is no longer being perceived by the one or more sensors of the perception system.

Abstract: Aspects of the disclosure provide systems and methods for confirming the identity of a passenger and changing destination of a vehicle. This may include receiving dispatching instructions to pick up a first passenger at a pickup location and to drop off the first passenger at a first destination as well as authentication information for authenticating a first client computing device of the first passenger. Once the client device is authenticated and a second passenger enters the vehicle, the vehicle is maneuvered towards the first destination. While doing so, a location of the vehicle is compared to location information received from the client computing devices. A notification is sent to a dispatching server based on the comparison and a second destination location is received in response. The vehicle is then maneuvered towards the second destination instead of the first destination.

Abstract: Aspects of the disclosure relate to methods for controlling a vehicle having an autonomous driving mode. For instance, sensor data may be received from one or more sensors of the perception system of the vehicle, the sensor data identifying characteristics of an object perceived by the perception system. When it is determined that the object is no longer being perceived by the one or more sensors of the perception system, predicted characteristics for the object may be generated based on one or more of the identified characteristics. The predicted characteristics of the object may be used to control the vehicle in the autonomous driving mode such that the vehicle is able to respond to the object when it is determined that the object is no longer being perceived by the one or more sensors of the perception system.

Abstract: An apparatus includes a machine for manufacturing a product from one or more input materials, with the machine including at least a sensor, a control panel, and a switch through which operation of the machine can be stopped. The apparatus further includes a physical display device and a computing device communicationally coupled to both the machine and the physical display device, the computing device causing the physical display device to display user interface that has a first portion displaying an availability indicator, a second portion displaying a performance indicator and a third portion displaying a quality indicator. The computing device can determine the availability indicator, the performance indicator and the quality indicator from data received from the machine and from the operator thereof. Restarting of the machine can be prevented until a reason for the machine's stoppage is received, with the reason being optionally computer-validated to enable restart.

Abstract: Some embodiments relate to a first electronic network node is provided (110) configured for a cryptographic operation. The first network node is configured to receive as input a difficulty parameter (d), and a structure parameter (n), and to obtain a shared matrix (A), the shared matrix being shared a second network node through a communication interface, entries in the shared matrix (A) being selected modulo a first modulus (q), the shared matrix (A) being a square matrix (k×k) of dimension (k) equal to the difficulty parameter (d) divided by the structure parameter (n), the entries in the shared matrix (A) being polynomials modulo a reduction polynomial (ƒ) of degree equal to the structure parameter (n), said cryptographic operation using the shared matrix.

Abstract: Aspects of the present disclosure relate to context aware stopping of a vehicle without a driver. As an example, after a passenger has entered the vehicle, the vehicle is maneuvered by one or more processors in an autonomous driving mode towards a destination location along a route. The route is divided into two or more stages. A signal is received by the one or more processors. The signal indicates that the passenger is requesting that the vehicle stop or pull over. In response to the signal, the one or more processors determine a current stage of the route based on a current distance of the vehicle from a pickup location where the passenger entered the vehicle or a current distance of the vehicle from the destination location. The one or more processors then stop the vehicle in accordance with the determined current stage.

Abstract: Aspects of the disclosure provide systems and methods for recognizing an assigned passenger. For instance, dispatching instructions to pick up a passenger at a pickup location are received. The instructions include authentication information for authenticating a client computing device associated with the passenger. A vehicle is maneuvered in an autonomous driving mode towards the pickup location. The client device is then authenticated. After authentication, a set of pedestrians within a predetermined distance of the vehicle are identified from sensor information generated by a sensor of the vehicle and location information is received over a period of time from the client device. The received location information is used to estimate a velocity of the passenger. This estimated velocity is used to identify a subset of set of pedestrians that is likely to be the passenger. The vehicle is stopped to allow the passenger to enter the vehicle based on the subset.

Abstract: Aspects of the present disclosure relate to context aware stopping of a vehicle without a driver. As an example, after a passenger has entered the vehicle, the vehicle is maneuvered by one or more processors in an autonomous driving mode towards a destination location along a route. The route is divided into two or more stages. A signal is received by the one or more processors. The signal indicates that the passenger is requesting that the vehicle stop or pull over. In response to the signal, the one or more processors determine a current stage of the route based on a current distance of the vehicle from a pickup location where the passenger entered the vehicle or a current distance of the vehicle from the destination location. The one or more processors then stop the vehicle in accordance with the determined current stage.