Abstract: This disclosure describes techniques for fabricating a high-resolution, non-cytotoxic and transparent microfluidic device. A material can be selected based on having an optical property with a predetermined degree of transparency to provide viewability of a biological sample through the microfluidic device and a level of cytotoxicity within a predetermined threshold to provide viability of the biological sample within the microfluidic device. An additive manufacturing technique can be selected from a plurality of additive manufacturing techniques for fabricating the microfluidic device based on the selected material to provide a resolution of dimensions of one or more channels of the microfluidic device higher than a predetermined resolution threshold.

Abstract: Embodiments include apparatus for compacting an object onto a rigid tool by applying a negative pressure while the scroll of material overlays the object. The apparatus comprises one or more spindles and a scroll of material that is stored on the one or more spindles. The scroll of material comprises a permeable layer and an impermeable membrane wherein the impermeable membrane contacts the permeable layer and may extend beyond a perimeter of the permeable layer.

Abstract: A vacuum system and methods of managing an object against a support structure are presented. A vacuum system for at least one of holding or compacting an object is presented. The vacuum system comprises an impermeable layer, a number of pressure inlets extending through the impermeable layer, and a number of valve handles connected to the number of pressure inlets. The number of valve handles is configured to actuate between an active position applying a vacuum to the impermeable layer or an inactive position venting the impermeable layer to atmosphere.

Abstract: A vacuum system end effector and methods of use are presented. A method of picking and placing an object applies a negative pressure to a first chamber of a base of a vacuum system end effector. The negative pressure is supplied from the first chamber to a first region of a manifold to lift the object while venting a second chamber of the base to atmosphere. A barrier is moved away from an opening in the first chamber to supply negative pressure from the first chamber of the base to the second chamber of the base. A number of vents through the second chamber is blocked to cease venting to atmosphere. The negative pressure is supplied from the second chamber to a second region of the manifold to compress the object.

Abstract: Composite compaction system and method of use are presented. A method of supporting a composite compaction system is presented. A number of morphable bag supports of the composite compaction system is held in a retracted state. A contact face of a vacuum bag of the composite compaction system is placed in contact with a composite material on a support structure. The number of morphable bag supports is placed in an engaged state to conform to the support structure.

Abstract: Systems and methods are provided for compacting objects onto tools. One embodiment is a method for compacting an object onto a rigid tool. The method includes placing an object onto a surface of a rigid tool, disposing an end effector over the object, spreading linkages of the end effector, causing a scroll of material between the linkages to be disposed atop the object while surrounding the object, and applying a negative pressure to the scroll that offsets air leaks between the scroll and the object, thereby forming a suction hold that compacts the object onto the rigid tool.

Abstract: A film layer adhered to a ply of prepreg is separated from the ply by clamping the ply between two clamping members and flicking an exposed edge of the ply.

Abstract: Systems and methods are provided for handling objects. One embodiment is an apparatus for handling objects. The apparatus includes a vacuum securement head. The vacuum securement head includes a strongback, and an array of end effectors arranged at the strongback in conformance with a contour. The contour is complementary to a pickup tool. The array of end effectors is configured to pickup objects at the pickup tool. The vacuum securement head also includes an impermeable membrane that is penetrated by the end effectors, and a vacuum system configured to provide suction through the end effectors. The suction is configured to remove air between the impermeable membrane and a rigid tool, and offset air leaks between the impermeable membrane and the rigid tool.

Abstract: This disclosure describes microfluidic tissue biopsy and immune response drug evaluation devices and systems. A microfluidic device can include an inlet channel having a first end configured to receive a fluid sample optionally containing a tissue sample. The microfluidic device can also include a tissue trapping region at the second end of the inlet channel downstream from the first end. The tissue trapping region can include one or more tissue traps configured to catch a tissue sample flowing through the inlet channel such that the fluid sample contacts the tissue trap. The microfluidic device can also include one or more channels providing an outlet.

Abstract: This disclosure describes microfluidic tissue biopsy and immune response drug evaluation devices and systems. A microfluidic device can include an inlet channel having a first end configured to receive a fluid sample optionally containing a tissue sample. The microfluidic device can also include a tissue trapping region at the second end of the inlet channel downstream from the first end. The tissue trapping region can include one or more tissue traps configured to catch a tissue sample flowing through the inlet channel such that the fluid sample contacts the tissue trap. The microfluidic device can also include one or more channels providing an outlet.

Abstract: Certain aspects of the present disclosure provide techniques for an end effector system. The end effector system includes an end effector coupled to a gimbal assembly, wherein the end effector is configured to grasp an object and the gimbal assembly is attached to a shaft. The end effector system includes a first actuator coupled to the shaft and configured to move the shaft and a self-alignment assembly. The self-alignment assembly includes a first surface coupled to the end effector and a second surface coupled to the first actuator and configured to interface with the first surface, wherein the first actuator is configured to move the shaft such that the first surface engages the second surface to position the gimbal assembly at a first position.

Abstract: This disclosure describes techniques for fabricating a high-resolution, non-cytotoxic and transparent microfluidic device. A material can be selected based on having an optical property with a predetermined degree of transparency to provide viewability of a biological sample through the microfluidic device and a level of cytotoxicity within a predetermined threshold to provide viability of the biological sample within the microfluidic device. An additive manufacturing technique can be selected from a plurality of additive manufacturing techniques for fabricating the microfluidic device based on the selected material to provide a resolution of dimensions of one or more channels of the microfluidic device higher than a predetermined resolution threshold.

Abstract: This disclosure describes microfluidic tissue biopsy and immune response drug evaluation devices and systems. A microfluidic device can include an inlet channel having a first end configured to receive a fluid sample optionally containing a tissue sample. The microfluidic device can also include a tissue trapping region at the second end of the inlet channel downstream from the first end. The tissue trapping region can include one or more tissue traps configured to catch a tissue sample flowing through the inlet channel such that the fluid sample contacts the tissue trap. The microfluidic device can also include one or more channels providing an outlet.

Abstract: Systems and methods are provided for handling objects. One embodiment is an apparatus for handling objects. The apparatus includes a vacuum securement head. The vacuum securement head includes a strongback, and an array of end effectors arranged at the strongback in conformance with a contour. The contour is complementary to a pickup tool. The array of end effectors is configured to pickup objects at the pickup tool. The vacuum securement head also includes an impermeable membrane that is penetrated by the end effectors, and a vacuum system configured to provide suction through the end effectors. The suction is configured to remove air between the impermeable membrane and a rigid tool, and offset air leaks between the impermeable membrane and the rigid tool.

Abstract: Systems and methods are provided for compacting objects onto tools. One embodiment is a method for compacting an object onto a rigid tool. The method includes placing an object onto a surface of a rigid tool, disposing an end effector over the object, spreading linkages of the end effector, causing a scroll of material between the linkages to be disposed atop the object while surrounding the object, and applying a negative pressure to the scroll that offsets air leaks between the scroll and the object, thereby forming a suction hold that compacts the object onto the rigid tool.

Abstract: This disclosure describes microfluidic tissue biopsy and immune response drug evaluation devices and systems. A microfluidic device can include an inlet channel having a first end configured to receive a fluid sample optionally containing a tissue sample. The microfluidic device can also include a tissue trapping region at the second end of the inlet channel downstream from the first end. The tissue trapping region can include one or more tissue traps configured to catch a tissue sample flowing through the inlet channel such that the fluid sample contacts the tissue trap. The microfluidic device can also include one or more channels providing an outlet.

Abstract: This disclosure describes techniques for fabricating a high-resolution, non-cytotoxic and transparent microfluidic device. A material can be selected based on having an optical property with a predetermined degree of transparency to provide viewability of a biological sample through the microfluidic device and a level of cytotoxicity within a predetermined threshold to provide viability of the biological sample within the microfluidic device. An additive manufacturing technique can be selected from a plurality of additive manufacturing techniques for fabricating the microfluidic device based on the selected material to provide a resolution of dimensions of one or more channels of the microfluidic device higher than a predetermined resolution threshold.

Abstract: A controlled release system includes a polymeric support, wherein the polymeric support is biodegradable; a polymeric matrix, wherein the polymeric matrix includes polyhydroalkanoate; and encapsulated gases or volatiles; and a controlled release system includes a polymeric support; a polymeric matrix, wherein the polymeric matrix includes (poly-3-hydroxybutyrate-co-3-hydroxyvalerate) and poly (?-caprolactone); and encapsulated gases or volatiles.

Abstract: This disclosure describes microfluidic tissue biopsy and immune response drug evaluation devices and systems. A microfluidic device can include an inlet channel having a first end configured to receive a fluid sample optionally containing a tissue sample. The microfluidic device can also include a tissue trapping region at the second end of the inlet channel downstream from the first end. The tissue trapping region can include one or more tissue traps configured to catch a tissue sample flowing through the inlet channel such that the fluid sample contacts the tissue trap. The microfluidic device can also include one or more channels providing an outlet.

Abstract: A controlled release system includes a polymeric support, wherein the polymeric support is biodegradable; a polymeric matrix, wherein the polymeric matrix includes polyhydroalkanoate; and encapsulated gases or volatiles; and a controlled release system includes a polymeric support; a polymeric matrix, wherein the polymeric matrix includes (poly-3-hydroxybutyrate-co-3-hydroxyvalerate) and poly (?-caprolactone); and encapsulated gases or volatiles.